Neuroendocrine pharmacology of stress

Carrasco, Gonzalo A; Van de Kar, Louis D

doi:10.1016/s0014-2999(03)01285-8

Cited by 914Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

Neuroendocrine pharmacology of stress

Carrasco, Gonzalo A, Van de Kar, Louis D·2003·European Journal of Pharmacology

DOI 10.1016/s0014-2999(03)01285-8

Open this paper in CoChat — free account

Abstract

Exposure to hostile conditions initiates responses organized to enhance the probability of survival. These coordinated responses, known as stress responses, are composed of alterations in behavior, autonomic function and the secretion of multiple hormones. The activation of the renin-angiotensin system and the hypothalamic-pituitary-adrenocortical axis plays a pivotal role in the stress response. Neuroendocrine components activated by stressors include the increased secretion of epinephrine and norepinephrine from the sympathetic nervous system and adrenal medulla, the release of corticotropin-releasing factor (CRF) and vasopressin from parvicellular neurons into the portal circulation, and seconds later, the secretion of pituitary adrenocorticotropin (ACTH), leading to secretion of glucocorticoids by the adrenal gland. Corticotropin-releasing factor coordinates the endocrine, autonomic, behavioral and immune responses to stress and also acts as a neurotransmitter or neuromodulator in the amygdala, dorsal raphe nucleus, hippocampus and locus coeruleus, to integrate brain multi-system responses to stress. This review discussed the role of classical mediators of the stress response, such as corticotropin-releasing factor, vasopressin, serotonin (5-hydroxytryptamine or 5-HT) and catecholamines. Also discussed are the roles of other neuropeptides/neuromodulators involved in the stress response that have previously received little attention, such as substance P, vasoactive intestinal polypeptide, neuropeptide Y and cholecystokinin. Anxiolytic drugs of the benzodiazepine class and other drugs that affect catecholamine, GABA(A), histamine and serotonin receptors have been used to attenuate the neuroendocrine response to stressors. The neuroendocrine information for these drugs is still incomplete; however, they are a new class of potential antidepressant and anxiolytic drugs that offer new therapeutic approaches to treating anxiety disorders. The studies described in this review suggest that multiple brain mechanisms are responsible for the regulation of each hormone and that not all hormones are regulated by the same neural circuits. In particular, the renin-angiotensin system seems to be regulated by different brain mechanisms than the hypothalamic-pituitary-adrenal system. This could be an important survival mechanism to ensure that dysfunction of one neurotransmitter system will not endanger the appropriate secretion of hormones during exposure to adverse conditions. The measurement of several hormones to examine the mechanisms underlying the stress response and the effects of drugs and lesions on these responses can provide insight into the nature and location of brain circuits and neurotransmitter receptors involved in anxiety and stress.

Integrity signals

Registry

Crossref · 10.1016/s0014-2999(03)01285-8

Cites

643 of 643 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

When the brain receives stress input, multiple pathways containing the autonomic nervous system and hypothalamic-pituitary-adrenal axis (HPA axis) are activated.
“When the brain receives stress input, multiple pathways containing the autonomic nervous system and hypothalamic-pituitary-adrenal axis (HPA axis) are activated (20).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [20]

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
Sapolsky, R. M., Romero, L. M., & Munck, A. U. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.1.0389 · Cited by 7,541 · see citing works
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
Sapolsky, R. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.1.55 · Cited by 7,533 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 2,997 · see citing works
Gender differences in depression: Critical review
Piccinelli, M., & Wilkinson, G. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.486 · Cited by 2,376 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
Swanson, L. W., & Sawchenko, P. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001413 · Cited by 1,991 · see citing works
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953 · see citing works
Cardiovascular Disease Outcomes During 6.8 Years of Hormone Therapy
Grady, D. G., Herrington, D. M., Bittner, V., Blumenthal, R. S., Davidson, M., Hlatky, M. A., Hsia, J. A., Hulley, S. B., Herd, A. J., Khan, S. S., et al. (2002) · JAMA · doi:10.1001/jama.288.1.49 · Cited by 1,926 · see citing works
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*
JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739 · see citing works
Emotion: Clues from the Brain
LeDoux, J. E. (1995) · Annual Review of Psychology · doi:10.1146/annurev.ps.46.020195.001233 · Cited by 1,646 · see citing works
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352 · see citing works
MONOAMINE OXIDASE: From Genes to Behavior
Shih, J. C., Chen, K., & Ridd, M. J. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.197 · Cited by 1,211 · see citing works
Physiology and pharmacology of corticotropin-releasing factor.
Owens, M. J., & Nemeroff, C. B. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06673-6 · Cited by 1,147 · see citing works
The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat
Sawchenko, P. E., & Swanson, L. W. (1982) · Brain Research Reviews · doi:10.1016/0165-0173(82)90010-8 · Cited by 1,141 · see citing works
Neurotransmitter functions of mammalian tachykinins.
Otsuka, M., & Yoshioka, K. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.229 · Cited by 1,091 · see citing works
Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors
Kramer, M. S., Cutler, N. R., Feighner, J. P., Shrivastava, R. K., Carman, J. S., Sramek, J. J., Reines, S. A., Liu, G. F., Snavely, D. B., Wyatt-Knowles, E. S., et al. (1998) · Science · doi:10.1126/science.281.5383.1640 · Cited by 1,071 · see citing works
Stress in Health and Disease
(1976) · Elsevier eBooks · doi:10.1016/c2013-0-06263-9 · Cited by 982 · see citing works
Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925 · see citing works
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925 · see citing works
Expression cloning of a human corticotropin-releasing-factor receptor.
Chen, R., Lewis, K. A., Perrin, M. H., & Vale, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8967 · Cited by 925 · see citing works
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919 · see citing works
Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892 · see citing works
Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60
Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works
The Metabolism of Fatty Acids in the Rat VI. Arachidonic Acid
Göransson, G. (1965) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1965.tb04148.x · Cited by 865 · see citing works
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850 · see citing works
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain.
Lovenberg, T. W., Liaw, C. W., Grigoriadis, D. E., Clevenger, W., Chalmers, D. T., Souza, E. B. D., & Oltersdorf, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.836 · Cited by 846 · see citing works
Synthesis, transport, and release of posterior pituitary hormones
Brownstein, M. J., Russell, J. T., & Gainer, H. (1980) · Science · doi:10.1126/science.6153132 · Cited by 838 · see citing works
Neurotransmission in the rat amygdala related to fear and anxiety
Davis, M., Rainnie, D., & Cassell, M. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90106-6 · Cited by 771 · see citing works
Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide
Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90101-i · Cited by 745 · see citing works
Corticotropin releasing factor produces behavioural activation in rats
Sutton, R., Koob, G., le Moal, M., Rivier, J., & Vale, W. (1982) · Nature · doi:10.1038/297331a0 · Cited by 744 · see citing works
Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus
Cunningham, E. T., & Sawchenko, P. E. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902740107 · Cited by 727 · see citing works
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.624 · Cited by 721 · see citing works
Two brain cholecystokinin receptors: implications for behavioral actions
Moran, T. H., Robinson, P. H., Goldrich, M. S., & McHugh, P. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91413-7 · Cited by 715 · see citing works
Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial.
Soares, C. N., Almeida, O., Joffe, H., & Cohen, L. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.529 · Cited by 715 · see citing works
Biological actions of cholecystokinin
Crawley, J. N., & Corwin, R. L. (1994) · Peptides · doi:10.1016/0196-9781(94)90104-x · Cited by 713 · see citing works
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated
Zobel, A. W., Nickel, T., Künzel, H. E., Ackl, N., Sonntag, A., Ising, M., & Holsboer, F. (2000) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00016-9 · Cited by 705 · see citing works
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
Plotsky, P. M., Owens, M. J., & Nemeroff, C. B. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70006-x · Cited by 672 · see citing works
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667 · see citing works
Variations in the hypothalamic-pituitary-adrenal response to stress during the estrous cycle in the rat
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666 · see citing works
Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus
Sawchenko, P. E., Swanson, L. W., Grzanna, R., Howe, P. R. C., Bloom, S. R., & Polak, J. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410203 · Cited by 663 · see citing works
Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Grasby, P. M., & Cowen, P. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.2.174 · Cited by 642 · see citing works
The Tachykinin Peptide Family
Severini, C., Improta, G., Falconieri-Erspamer, G., Salvadori, S., & Erspamer, V. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.285 · Cited by 638 · see citing works
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · see citing works
Corticotropin-releasing factor, norepinephrine, and stress
Koob, G. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00164-x · Cited by 629 · see citing works
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S., Hill, J. K., Pantely, G. A., Hohimer, A. R., et al. (2000) · Nature Genetics · doi:10.1038/74255 · Cited by 588 · see citing works
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582 · see citing works
Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system—II. Immunohistochemical analysis
de Quidt, M. E., & Emson, P. C. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90057-6 · Cited by 569 · see citing works
Transdermal oestrogen for treatment of severe postnatal depression
Grégoire, A., Kumar, R., Everitt, B. J., & Studd, J. W. W. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91414-2 · Cited by 559 · see citing works
Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain
Wright, D. E., Seroogy, K. B., Lundgren, K. H., Davis, B. M., & Jennes, L. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903510304 · Cited by 548 · see citing works
Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541 · see citing works
The pharmacologic alteration of renin release.
Keeton, T. K., & Campbell, W. B. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06838-3 · Cited by 540 · see citing works
Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537 · see citing works
The CRF peptide family and their receptors: yet more partners discovered
Dautzenberg, F. M., & Hauger, R. L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)01946-6 · Cited by 534 · see citing works
Neuroendocrinology and pathophysiology of the stress system
STRATAKIS, C. A., & CHROUSOS, G. P. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44666.x · Cited by 533 · see citing works
Catecholaminergic Modulation of Corticotropin-Releasing Factor and Adrenocorticotropin Secretion
Plotsky, P. M., Cunningham, E. T., & Widmaier, E. P. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-4-437 · Cited by 530 · see citing works
Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
Fletcher, A., Forster, E. A., Bill, D. J., Brown, G., Cliffe, I. A., Hartley, J. E., Jones, D. E., McLenachan, A. P., Stanhope, K. J., Critchley, D. J. P., et al. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00118-0 · Cited by 526 · see citing works
Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat
Vanderhaeghen, J. J., Lotstra, F., Mey, J. D., & Gilles, C. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.1190 · Cited by 523 · see citing works
Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression
Reul, J. M. H. M. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00117-5 · Cited by 515 · see citing works
Structure of Porcine Cholecystokinin‐Pancreozymin
Mutt, V., & Jorpes, J. E. (1968) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1968.tb00433.x · Cited by 505 · see citing works
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502 · see citing works
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart.
Perrin, M. H., Donaldson, C. J., Chen, R., Blount, A. L., Berggren, T., Bilezikjian, L. M., Sawchenko, P. E., & Vale, W. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2969 · Cited by 502 · see citing works
The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide
Lutz, E. M., Sheward, W. J., West, K. M., Morrow, J. A., Fink, G., & Harmar, A. J. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81668-p · Cited by 497 · see citing works
Physiopharmacological interactions between stress hormones and central serotonergic systems
Chaouloff, F. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90005-k · Cited by 494 · see citing works
Co-expression of corticotropin-releasing factor and vasopressin immunoreactivity in parvocellular neurosecretory neurons of the adrenalectomized rat.
Sawchenko, P. E., Swanson, L. W., & Vale, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.6.1883 · Cited by 485 · see citing works
On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation
Ratka, A., Sutanto, W., Bloemers, M., & de Kloet, E. R. (2008) · Neuroendocrinology · doi:10.1159/000125210 · Cited by 476 · see citing works
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior
Stenzel‐Poore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F., & Vale, W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02579.1994 · Cited by 468 · see citing works
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
Lovenberg, T. W., Chalmers, D. T., Liu, C., & Souza, E. B. D. (1995) · Endocrinology · doi:10.1210/endo.136.9.7544278 · Cited by 457 · see citing works
Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats
Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457 · see citing works
Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression.
Wank, S. A., Pisegna, J. R., & de Weerth, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.18.8691 · Cited by 448 · see citing works
Chronic estrogen-induced alterations in adrenocorticotropin and corticosterone secretion, and glucocorticoid receptor-mediated functions in female rats
Burgess, L. H., & Handa, R. J. (1992) · Endocrinology · doi:10.1210/endo.131.3.1324155 · Cited by 445 · see citing works
NEUROENDOCRINOLOGY OF STRESS
Habib, K. E., Gold, P. W., & Chrousos, G. P. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70208-5 · Cited by 439 · see citing works
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress
Imaki, T., Nahan, J., RIVIER, C. L., Sawchenko, P., & Vale, W. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00585.1991 · Cited by 434 · see citing works
Estrogen control of central neurotransmission: Effect on mood, mental state, and memory
Fink, G., SUMNER, B. E. H., Rosie, R., Grace, O., & Quinn, J. P. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088099 · Cited by 431 · see citing works
Modification of 5‐HT neuron properties by sustained administration of the 5‐HT1A agonist gepirone: Electrophysiological studies in the rat brain
Blier, P. U., & de Montigny, C. (1987) · Synapse · doi:10.1002/syn.890010511 · Cited by 426 · see citing works
Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study
Cummings, S., Elde, R., Ells, J., & Lindall, A. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01355.1983 · Cited by 414 · see citing works
Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression
Raadsheer, F. C., van Heerikhuize, J. J., Lucassen, P. J., Hoogendijk, W. J. G., Tilders, F. J. H., & Swaab, D. F. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1372 · Cited by 411 · see citing works
Interaction of Corticotropin-Releasing Factor and Arginine Vasopressin on Adrenocorticotropin Secretion in Vivo *
RIVIER, C. L., & Vale, W. (1983) · Endocrinology · doi:10.1210/endo-113-3-939 · Cited by 409 · see citing works
Modifications of the Serotonin System by Antidepressant Treatments
Blier, P. U., de Montigny, C., & Chaput, Y. (1987) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198712001-00003 · Cited by 406 · see citing works
Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2
Radulovic, J., Rühmann, A., Liepold, T., & Spiess, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05016.1999 · Cited by 402 · see citing works
Corticotropin-releasing factor receptors: Physiology, pharmacology, biochemistry and role in central nervous system and immune disorders
Souza, E. B. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00011-9 · Cited by 397 · see citing works
The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
Mongeau, R., Blier, P., & de Montigny, C. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00017-3 · Cited by 391 · see citing works
Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an american indian population
Long, J. C., Knowler, W. C., Hanson, R. L., Robin, R. W., Urbanek, M., Moore, E., Bennett, P. H., & Goldman, D. A. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980508)81:3 · Cited by 389 · see citing works
The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat
Carey, M. P., Deterd, C. H., de Koning, J., Helmerhorst, F., & de Kloet, E. R. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1440311 · Cited by 385 · see citing works
Forebrain Pathways Mediating Stress-Induced Hormone Secretion
de Kar, L. D. V., & Blair, M. L. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0172 · Cited by 380 · see citing works
Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. I. Acutely presented stressful and nonstressful stimuli
Abercrombie, E., & Jacobs, B. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02837.1987 · Cited by 377 · see citing works
CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.
Schulz, D. W., Mansbach, R. S., Sprouse, J. S., Braselton, J. P., Collins, J. L., Corman, M. L., Dunaiskis, A. R., Faraci, S., Schmidt, A. W., Seeger, T., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10477 · Cited by 377 · see citing works
Vasopressinergic regulation of the hypothalamic–pituitary–adrenal axis: implications for stress adaptation
Aguilera, G., & Rabadan-Diehl, C. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00196-8 · Cited by 375 · see citing works
Autoradiographic localization and biochemical characterization of peripheral type CCK receptors in rat CNS using highly selective nonpeptide CCK antagonists
Dr, H., Campbell, N., Shaw, T., & Gn, W. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02967.1987 · Cited by 356 · see citing works
Vasopressin Receptors
Birnbaumer, M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00304-0 · Cited by 343 · see citing works
Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System
Bittencourt, J. C., & Sawchenko, P. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01142.2000 · Cited by 339 · see citing works
Extrapituitary expression of the rat V1b vasopressin receptor gene.
Lolait, S. J., O’Carroll, A., Mahan, L. C., Felder, C. C., Button, D. C., Young, W. S., Mezey, É., & Brownstein, M. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6783 · Cited by 337 · see citing works
Direct Projections from the Central Amygdaloid Nucleus to the Hypothalamic Paraventricular Nucleus: Possible Role in Stress-Induced Adrenocorticotropin Release
Gray, T. S., Carney, M. E., & Magnuson, D. J. (2008) · Neuroendocrinology · doi:10.1159/000125260 · Cited by 331 · see citing works
Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors
Vita, N., Laurent, P., Lefort, S., Chalon, P., Lélias, J.-M., Kaghad, M., Fur, G. L., Caput, D., & Ferrara, P. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80427-v · Cited by 323 · see citing works
Cholecystokinin Tetrapeptide Induces Panic-like Attacks in Healthy Volunteers
de Montigny, C. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810060031006 · Cited by 323 · see citing works
Stress Hormones: Good and Bad
Sapolsky, R. M. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0350 · Cited by 316 · see citing works
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
Thorsell, A., Michalkiewicz, M., Dumont, Y., Quirion, R., Caberlotto, L., Rimondini, R., Mathé, A. A., & Heilig, M. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220232997 · Cited by 315 · see citing works
Distribution of neuropeptides in the limbic system of the rat: The amygdaloid complex
Roberts, G. W., Woodhams, P. L., Polak, J. M., & Crow, T. J. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90156-7 · Cited by 312 · see citing works
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation
WEBSTER, E. L., Lewis, D. B., Torpy, D. J., Zachman, E. K., Rice, K. C., & Chrousos, G. P. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940412 · Cited by 312 · see citing works
Amygdaloid Corticotropin‐Releasing Factor Targets Locus Coeruleus Dendrites: Substrate for the Co‐ordination of Emotional and Cognitive Limbs of the Stress Response
Van Bockstaele, E. J., Colago, E. E. O., & Valentino, R. J. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00254.x · Cited by 311 · see citing works
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Kirby, L. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00093-7 · Cited by 307 · see citing works
Rat brain binds adrenal steroid hormone: Radioautography of hippocampus with corticosterone
Gerlach, J. L., & McEwen, B. S. (1972) · Science · doi:10.1126/science.175.4026.1133 · Cited by 306 · see citing works
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function
Santarelli, L., Gobbi, G., Debs, P. C., Sibille, E. L., Blier, P., Hen, R., & Heath, M. J. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1912 · Cited by 303 · see citing works
The Locus Coeruleus as a Site for Integrating Corticotropin‐Releasing Factor and Noradrenergic Mediation of Stress Responsesa
Valentino, R. J., Foote, S. L., & Page, M. E. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49931.x · Cited by 292 · see citing works
Brain monoamines, exercise, and behavioral stress: animal models
DISHMAN, R. K. (1997) · Medicine &amp Science in Sports &amp Exercise · doi:10.1097/00005768-199701000-00010 · Cited by 291 · see citing works
Amygdaloid CRF Pathways: Role in Autonomic, Neuroendocrine, and Behavioral Responses to Stress
Gray, T. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49922.x · Cited by 288 · see citing works
The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.
Potter, E., Behan, D. P., Linton, E. A., Lowry, P. J., Sawchenko, P. E., & Vale, W. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4192 · Cited by 285 · see citing works
Corticotropin-Releasing Factor Decreases Plasma Luteinizing Hormone Levels in Female Rats by Inhibiting Gonadotropin-Releasing Hormone Release into Hypophysial-Portal Circulation*
Petraglia, F., Sutton, S. W., Vale, W., & Plotsky, P. M. (1987) · Endocrinology · doi:10.1210/endo-120-3-1083 · Cited by 285 · see citing works
Discovery of the antidepressant and anti-emetic efficacy of substance P receptor (NK1) antagonists
Rupniak, N. M. J., & Kramer, M. S. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01396-6 · Cited by 278 · see citing works
Immunohistochemical Localization of the Vasopressin V1b Receptor in the Rat Brain and Pituitary Gland: Anatomical Support for Its Involvement in the Central Effects of Vasopressin
Hernando, F., Schoots, O., Lolait, S. J., & Burbach, J. P. H. (2001) · Endocrinology · doi:10.1210/endo.142.4.8067 · Cited by 275 · see citing works
Alterations in brain norepinephrine metabolism induced by environmental stimuli previously paired with inescapable shock.
Cassens, G., Roffman, M., Kuruc, A., Orsulak, P. J., & Schildkraut, J. (1980) · Science · doi:10.1126/science.7403874 · Cited by 264 · see citing works
Activation of the locus coeruleus noradrenergic system by intracoerulear microinfusion of corticotropin-releasing factor: effects on discharge rate, cortical norepinephrine levels and cortical electroencephalographic activity.
Curtis, A., Lechner, S., Pavcovich, L. A., & Valentino, R. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36621-2 · Cited by 261 · see citing works
Pathways to the Secretion of Adrenocorticotropin: A View from the Portal*
Plotsky, P. M. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00231.x · Cited by 258 · see citing works
Serotonin and Stress
Chaouloff, F. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00008-1 · Cited by 256 · see citing works
Stimulation and destruction of the locus coeruleus: Opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex
Korf, J., Aghajanian, G. K., & Roth, R. H. (1973) · European Journal of Pharmacology · doi:10.1016/0014-2999(73)90131-3 · Cited by 256 · see citing works
Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats
Sarnyai, Z., Bíró, É., Gardi, J., Vecsernyés, M., Julesz, J., & Telegdy, G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00043-p · Cited by 255 · see citing works
Neurotransmitter Regulation of Cellular Activation and Neuropeptide Gene Expression in the Paraventricular Nucleus of the Hypothalamus
Cole, R. L., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00959.2002 · Cited by 253 · see citing works
Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide
Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., & Nagata, S. (1993) · Neuron · doi:10.1016/0896-6273(93)90188-w · Cited by 251 · see citing works
Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat
Senba, E., & Ueyama, T. (1997) · Neuroscience Research · doi:10.1016/s0168-0102(97)00095-3 · Cited by 249 · see citing works
Cholecystokinin-dopamine intearctions
Crawley, J. N. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90558-a · Cited by 249 · see citing works
Timing of Onset of Antidepressant Response With Fluoxetine Treatment
Nierenberg, A. A., Farabaugh, A. H., Alpert, J. E., Gordon, J., Worthington, J. J., Rosenbaum, J. F., & D, M. F. M. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.9.1423 · Cited by 247 · see citing works
Potentiation by Vasopressin of Corticotropin Release Induced by Corticotropin-Releasing Factor1
Yates, F. E., Russell, S. M., Dallman, M. F., Hedge, G. A., McCann, S. M., & DHARIWAL, A. P. S. (1971) · Endocrinology · doi:10.1210/endo-88-1-3 · Cited by 245 · see citing works
Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis
Kawahara, H., Yoshida, M., Yokoo, H., Nishi, M., & Tanaka, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90565-3 · Cited by 244 · see citing works
The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress**This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.
Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M.-L., Chrousos, G. P., Webster, E., et al. (1999) · Endocrinology · doi:10.1210/endo.140.1.6415 · Cited by 242 · see citing works
Neuroendocrine Pharmacology of Serotonergic (5-HT) Neurons
de Kar, L. D. V. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.001445 · Cited by 240 · see citing works
Prior exposure to chronic stress results in enhanced synthesis and release of hippocampal norepinephrine in response to a novel stressor
Nisenbaum, L., Zigmond, M., Sved, A., & Abercrombie, E. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-05-01478.1991 · Cited by 238 · see citing works
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1 S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
Griebel, G., Simiand, J., Steinberg, R., Jung, M., Gully, D., Roger, P., Geslin, M., Scatton, B., Maffrand, J., & Soubrié, P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.333 · Cited by 238 · see citing works
SEX STEROID CONTROL OF MOOD, MENTAL STATE AND MEMORY
Fink, G., SUMNER, B. E. H., McQueen, J. K., Wilson, H., & Rosie, R. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02151.x · Cited by 236 · see citing works
Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior
Heinrichs, S. C., Lapsansky, J., Lovenberg, T. W., Souza, E. B. D., & Chalmers, D. T. (1997) · Regulatory Peptides · doi:10.1016/s0167-0115(97)01005-7 · Cited by 235 · see citing works
The corticotropin-releasing hormone test in patients with posttraumatic stress disorder
Smith, M. A., Davidson, J. R. T., Ritchie, J., Kudler, H. S., Lipper, S., Chappell, P. B., & Nemeroff, C. B. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90050-4 · Cited by 234 · see citing works
Vasoactive Intestinal Peptide Is a Physiological Mediator of Prolactin Release in the Rat*
Abe, H., Engler, D., Molitch, M. E., BOLLINGER-GRUBER, J. A., & Reichlin, S. (1985) · Endocrinology · doi:10.1210/endo-116-4-1383 · Cited by 234 · see citing works
Co-localization of corticotropin-releasing factor and vasopressin in median eminence neurosecretory vesicles
Whitnall, M. H., Mezey, É., & Gainer, H. (1985) · Nature · doi:10.1038/317248a0 · Cited by 231 · see citing works
Comparative Study in the Rat of the Actions of Different Types of Stress on the Release of 5-HT in Raphe Nuclei and Forebrain Areas
Adell, A., CASANOVAS, J. M., & Artigas, F. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00048-8 · Cited by 229 · see citing works
Neuropeptide Y
Żukowska-Grójec, Z. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44683.x · Cited by 229 · see citing works
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐<i>fos</i> Induction Associated with Audiogenic Stress
Campeau, S., & Watson, S. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00593.x · Cited by 227 · see citing works
Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
M Price, B. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 226 · see citing works
Corticotropin-releasing factor: effects on the autonomic nervous system and visceral systems.
Brown, M. R., & Fisher, L. A. (1985) · PubMed · Cited by 223 · see citing works
Induction of c-Fos immunoreactivity in the rat forebrain by conditioned and unconditioned aversive stimuli
Pezzone, M. A., Lee, W., Hoffman, G. E., & Rabin, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91503-7 · Cited by 222 · see citing works
Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats
Liebsch, G., Landgraf, R., Gerstberger, R., Probst, J. C., Wotjak, C. T., Engelmann, M., Holsboer, F., & Montkowski, A. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(95)00099-w · Cited by 220 · see citing works
Neuropeptides: Regulators of Physiological Processes
Strand, F. L. (1999) · Medical Entomology and Zoology · Cited by 219 · see citing works
Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.
Parsons, L. H., Koob, G. F., & Weiss, F. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10596-x · Cited by 218 · see citing works
Organization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat
Wallace, D. M., Magnuson, D. J., & Gray, T. S. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90046-z · Cited by 218 · see citing works
Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure
Aghajanian, G. K., & VanderMaelen, C. P. (1982) · Journal of Neuroscience · doi:10.1523/jneurosci.02-12-01786.1982 · Cited by 217 · see citing works
Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus
Baker, K. G., Halliday, G. M., Hornung, J., Geffen, L. B., Cotton, R. G. H., & To¨rk, I. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90043-n · Cited by 217 · see citing works
Differential colocalization of estrogen receptor β (ERβ) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: An immunocytochemical study
Alves, S. E., López, V., McEwen, B. S., & Weiland, N. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3281 · Cited by 217 · see citing works
Transmitter systems involved in neural plasticity undelying increased anxiety and defense— Implications for understanding anxiety following traumatic stress
Adamec, R. E. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00055-3 · Cited by 216 · see citing works
Further Evidence for a Central Stimulatory Action of Catecholamines on Adrenocorticotropin Release in the Rat
SZAFARCZYK, A., Malaval, F., LAURENT, A., GIBAUD, R., & ASSENMACHER, I. (1987) · Endocrinology · doi:10.1210/endo-121-3-883 · Cited by 216 · see citing works
5-HT 2A Receptors Stimulate ACTH, Corticosterone, Oxytocin, Renin, and Prolactin Release and Activate Hypothalamic CRF and Oxytocin-Expressing Cells
de Kar, L. D. V., Javed, A., Zhang, Y., Serres, F., Raap, D. K., & Gray, T. S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03572.2001 · Cited by 214 · see citing works
Puberty onset of gender differences in rates of depression: a developmental, epidemiologic and neuroendocrine perspective
Angold, A. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90029-j · Cited by 212 · see citing works
Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone
Gesing, A., Bilang‐Bleuel, A., Droste, S. K., Linthorst, A. C. E., Holsboer, F., & Reul, J. M. H. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04822.2001 · Cited by 211 · see citing works
Restraint stress increases corticotropin-releasing hormone mRNA content in the amygdala and paraventricular nucleus
Kalin, N. H., Takahashi, L. K., & Chen, F. (1994) · Brain Research · doi:10.1016/0006-8993(94)91382-x · Cited by 211 · see citing works
Characterization of (2 S,4 R)-1-[5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1 H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a Selective and Orally Active Vasopressin V1b Receptor Antagonist
Gal, C. S.-L., Wagnon, J., Simiand, J., Griebel, G., Lacour, C., Guillon, G., Barberis, C., Brossard, G., Soubrié, P., Nisato, D., et al. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.3.1122 · Cited by 211 · see citing works
Corticotropin-Releasing Factor Increases<i>In Vitro</i>Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System
Lowry, C. A., Rodda, J. E., Lightman, S. L., & Ingram, C. D. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07728.2000 · Cited by 211 · see citing works
Neurophysin in the hypothalamo-neurohypophysial system. II. Immunocytochemical studies of the ontogeny of oxytocinergic and vasopressinergic neurons
Whitnall, M., Key, S., Ben-Barak, Y., Ozato, K., & Gainer, H. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-01-00098.1985 · Cited by 209 · see citing works
Behavioral stress responses in premenopausal and postmenopausal women and the effects of estrogen
Lindheim, S. R., Legro, R. S., Bernstein, L., Stanczyk, F. Z., Vijod, M. A., Presser, S. C., & Løbo, R. A. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91783-7 · Cited by 209 · see citing works
Cloning and characterization of the human V3 pituitary vasopressin receptor
de Keyzer, Y., Auzan, C., Lenne, F., Beldjord, C., Thibonnier, M., Bertagna, X., & Clauser, E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01268-7 · Cited by 209 · see citing works
Rewarding effects of opiates are absent in mice lacking the receptor for substance P
Murtra, P., Sheasby, A. M., Hunt, S. P., & Felipe, C. D. (2000) · Nature · doi:10.1038/35012069 · Cited by 208 · see citing works
Elevated CSF CRF in suicide victims
Arató, M., Bánki, C. M., Bissette, G., & Nemeroff, C. B. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90183-2 · Cited by 205 · see citing works
The corticotropin-releasing hormone stimulation test in patients with panic disorder
Roy‐Byrne, P., Uhde, T. W., Post, R. M., Gallucci, W. T., Chrousos, G. P., & Gold, P. W. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.896 · Cited by 204 · see citing works
Corticosterone and Serotonergic Neurotransmission in the Hippocampus: Functional Implications of Central Corticosteroid Receptor Diversity
Meijer, O. C., & de Kloet, E. R. (1998) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v12.i1-2.10 · Cited by 204 · see citing works
Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat
Baker, R. A., & Herkenham, M. A. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903580405 · Cited by 200 · see citing works
Behavioral effects of neuropeptide Y receptor agonists in the elevated plus-maze and fear-potentiated startle procedures
Broqua, P., Wettstein, J. G., Rocher, M. N., Gauthier-Martin, B., & Junien, J. (1995) · Behavioural Pharmacology · doi:10.1097/00008877-199504000-00001 · Cited by 198 · see citing works
Neuronal Activity and Neuropeptide Gene Transcription in the Brains of Immune‐Challenged Rats
Rivest, S., & Laflamme, N. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00788.x · Cited by 196 · see citing works
A molecular framework for the actions of glucocorticoid hormones in the nervous system
Evans, R. M., & Arriza, J. L. (1989) · Neuron · doi:10.1016/0896-6273(89)90177-3 · Cited by 196 · see citing works
Dual role of 5-HT in defense and anxiety
Graeff, F. G., Viana, M. D. B., & Mora, P. O. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00059-0 · Cited by 195 · see citing works
Cholecystokinin in the central nervous system: A minireview
Beinfeld, M. C. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90032-x · Cited by 195 · see citing works
Immune challenge and immobilization stress induce transcription of the gene encoding the CRF receptor in selective nuclei of the rat hypothalamus
Rivest, S., Laflamme, N., & Nappi, R. E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02680.1995 · Cited by 195 · see citing works
Implications of estrogen‐dependent brain organization for gender differences in hypothalamo‐pituitary‐adrenal regulation
Patchev, V. K., Hayashi, S., Orikasa, C., & Almeida, O. F. X. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896013 · Cited by 193 · see citing works
Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress
Makino, S., Schulkin, J. A., Smith, M. A., Pacák, K., Palkovits, M., & Gold, P. W. (1995) · Endocrinology · doi:10.1210/endo.136.10.7664672 · Cited by 193 · see citing works
Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain
Liebsch, G., Landgraf, R., Engelmann, M., Lörscher, P., & Holsboer, F. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)80047-2 · Cited by 191 · see citing works
Structural organization of the rat gene for the arginine vasopressin‐neurophysin precursor.
Schmale, H., Heinsohn, S., & Richter, D. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01497.x · Cited by 188 · see citing works
Abnormalities in the Regulation of Vasopressin and Corticotropin Releasing Factor Secretion in Obsessive-Compulsive Disorder
Altemus, M. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820010009002 · Cited by 186 · see citing works
Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport
Lundberg, J. M., Rudehill, A., Sollevi, A., Fried, G. M., & Wallin, G. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90193-0 · Cited by 185 · see citing works
The Role of Corticotropin-Releasing Factor in the Pathogenesis of Major Depression
Nemeroff, C. B. (1988) · Pharmacopsychiatry · doi:10.1055/s-2007-1014652 · Cited by 185 · see citing works
Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli
Abercrombie, E., & Jacobs, B. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02844.1987 · Cited by 184 · see citing works
Effect of restraint stress on food intake and body weight is determined by time of day
Rybkin, I. I., Zhou, Y., Vólaufová, J., Smagin, G. N., Ryan, D. H., & Harris, R. B. S. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1612 · Cited by 182 · see citing works
The Role of Corticotropin‐Releasing Factor in the Pathophysiology of Affective and Anxiety Disorders: Laboratory and Clinical Studies
Owens, M. J., & Nemeroff, C. B. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch15 · Cited by 181 · see citing works
The Panicogenic Effects of Cholecystokinin-Tetrapeptide Are Antagonized by L-365,260, a Central Cholecystokinin Receptor Antagonist, in Patients With Panic Disorder
Bradwejn, J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950060050005 · Cited by 181 · see citing works
Selective Control by Corticosterone of Serotonin Receptor Capacity in Raphe-Hippocampal System
de Kloet, E. R., Sybesma, H., & Reul, H. M. H. M. (2008) · Neuroendocrinology · doi:10.1159/000124496 · Cited by 180 · see citing works
I. CCK receptors: an exemplary family
Wank, S. A. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.274.4.g607 · Cited by 180 · see citing works
Corticotropin‐Releasing Factor Stimulates Catecholamine Release in Hypothalamus and Prefrontal Cortex in Freely Moving Rats as Assessed by Microdialysis
Lavický, J., & Dunn, A. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03191.x · Cited by 176 · see citing works
Autoradiographic characterization of (+-)-1-(2,5-dimethoxy-4-[125I] iodophenyl)-2-aminopropane ([125I]DOI) binding to 5-HT2 and 5-HT1c receptors in rat brain.
Appel, N. M., Mitchell, W. M., Garlick, R. K., Glennon, R. A., Teitler, M., & Souza, E. B. D. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23167-6 · Cited by 176 · see citing works
Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus
Bockstaele, E. J. V., Bajic, D., Proudfit, H. K., & Valentino, R. J. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00448-6 · Cited by 175 · see citing works
Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat
Maswood, S., Barter, J. E., Watkins, L. R., & Maier, S. F. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01313-9 · Cited by 173 · see citing works
Distribution and Coexistence of Corticotropin-Releasing Factor-, Neurotensin-, Enkephalin-, Cholecystokinin-, Galanin- and Vasoactive Intestinal Polypeptide/Peptide Histidine Isoleucine-Like Peptides in the Parvocellular Part of the Paraventricular Nucleus
Ceccatelli, S., Eriksson, M., & Hökfelt, T. (2008) · Neuroendocrinology · doi:10.1159/000125133 · Cited by 171 · see citing works
Is There a Future for Neuropeptide Receptor Ligands in the Treatment of Anxiety Disorders?
Griebel, G. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00041-2 · Cited by 171 · see citing works
Effects of Estrogen Antagonists and Agonists on the ACTH Response to Restraint Stress in Female Rats
Young, E. A. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00301-3 · Cited by 171 · see citing works
Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches
Moran, T. H., Smith, G. P., Hostetler, A. M., & McHugh, P. R. (1987) · Brain Research · doi:10.1016/0006-8993(87)90278-2 · Cited by 170 · see citing works
Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.
Melia, K., & Duman, R. S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8382 · Cited by 170 · see citing works
Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30
Rühmann, A., Bonk, I., Lin, C. R., Rosenfeld, M. G., & Spiess, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15264 · Cited by 170 · see citing works
Regulation of Serotonin Release in the Lateral Septum and Striatum by Corticotropin-Releasing Factor
Price, M. L., & Lucki, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02833.2001 · Cited by 169 · see citing works
Pharmacology of rapid-onset antidepressant treatment strategies.
Blier, P. U. (2001) · PubMed · Cited by 168 · see citing works
Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration
Hensler, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00395-5 · Cited by 168 · see citing works
Pharmacological blockade or genetic deletion of substance P (NK1) receptors attenuates neonatal vocalisation in guinea-pigs and mice
Rupniak, N. M. J., Carlson, E. C., Harrison, T., Oates, B. D., Seward, E. M., Owen, S. N., Felipe, C. D., Hunt, S. P., & Wheeldon, A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00052-6 · Cited by 168 · see citing works
Cholecystokinin Receptor Family
Wank, S. A., Pisegna, J. R., & de Weerth, A. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44052.x · Cited by 167 · see citing works
Anatomic basis for differential regulation of the rostrolateral peri–locus coeruleus region by limbic afferents
Bockstaele, E. J. V., Peoples, J. F., & Valentino, R. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00213-9 · Cited by 166 · see citing works

Flagged first, then by citations

13 of the 656 references couldn’t be matched to a known paper.

Sorted by citations

The expanded biology of serotonin
Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.042307.110802 · Cited by 2,100 · see citing works
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948 · see citing works
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590 · see citing works
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188 · see citing works
The impact of stress on body function: a review
Yaribeygi, H., Panahi, Y., Sahraei, H., Johnston, T. P., & Sahebkar, A. (2017) · EXCLI journal · doi:10.17179/excli2017-480 · Cited by 1,095 · see citing works
How stress influences the immune response
Padgett, D. A., & Glaser, R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00173-x · Cited by 1,059 · see citing works
The neurobiology and control of anxious states
Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine
Marik, P. E., Pastores, S. M., Annane, D., Meduri, G. U., Sprung, C. L., Arlt, W., Keh, D., Briegel, J., Beishuizen, A., Dimopoulou, I., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31817603ba · Cited by 912 · see citing works
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
Mather, M., Clewett, D., Sakaki, M., & Harley, C. W. (2016) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000667 · Cited by 695 · see citing works
The brain and the stress axis: the neural correlates of cortisol regulation in response to stress
Dedovic, K., Duchesne, A., Andrews, J., Engert, V., & Pruessner, J. C. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.074 · Cited by 699 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601 · see citing works
Role of GABA in anxiety and depression
Kalueff, A. V., & Nutt, D. (2006) · Depression and Anxiety · doi:10.1002/da.20262 · Cited by 536 · see citing works
Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma
Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Mouthon, D., Stouder, C., Dieben, K., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.60 · Cited by 516 · see citing works
Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress
Wang, J., Rao, H., Wetmore, G. S., Furlan, P. M., Korczykowski, M., Dinges, D. F., & Detre, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503082102 · Cited by 513 · see citing works
Vasopressin: Behavioral roles of an “original” neuropeptide
Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.007 · Cited by 504 · see citing works
The hypothalamic-neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: an old concept revisited
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Mechanisms of sepsis-induced organ dysfunction
Abraham, E. H., & Singer, M. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000282072.56245.91 · Cited by 442 · see citing works
Gender difference in neural response to psychological stress
Wang, J., Korczykowski, M., Rao, H., Yong Fan, A., Pluta, J. B., Gur, R. C., McEwen, B. S., & Detre, J. A. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm018 · Cited by 447 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Fetal Pain
Lee, S. H., Ralston, H. J., Drey, E. A., Partridge, J. C., & Rosen, M. A. (2005) · JAMA · doi:10.1001/jama.294.8.947 · Cited by 413 · see citing works
Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats
Campos, A. C., & Guimarães, F. S. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1168-x · Cited by 364 · see citing works
Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition
Bandelow, B., Baldwin, D., Abelli, M., Bolea-Alamanac, B., Bourin, M., Chamberlain, S. R., Cinosi, E., Davies, S., Domschke, K., Fineberg, N., et al. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1190867 · Cited by 347 · see citing works
Interpreting Stress Responses during Routine Toxicity Studies
Everds, N. E., Snyder, P. W., Bailey, K. L., Bolon, B. N., Creasy, D. M., Foley, G. L., Rosol, T. J., & Sellers, T. S. (2013) · Toxicologic Pathology · doi:10.1177/0192623312466452 · Cited by 338 · see citing works
Role of neuropeptides in anxiety, stress, and depression: From animals to humans
Kormos, V., & Gaszner, B. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.014 · Cited by 327 · see citing works
Plasticizer endocrine disruption: Highlighting developmental and reproductive effects in mammals and non-mammalian aquatic species
Mathieu‐Denoncourt, J., Wallace, S. J., de Solla, S. R., & Langlois, V. S. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.11.003 · Cited by 311 · see citing works
Critical Illness-Related Corticosteroid Insufficiency
Marik, P. E. (2009) · Chest · doi:10.1378/chest.08-1149 · Cited by 299 · see citing works
Stress and the HPA Axis: Balancing Homeostasis and Fertility.
Joseph, D., & Whirledge, S. (2017) · International journal of molecular sciences · doi:10.3390/ijms18102224 · Cited by 290 · see citing works
“In order to restore homeostatic conditions, organisms activate a complex range of responses involving the endocrine, nervous, and immune systems, collectively known as the stress response [2].”
Background
Amphetamine toxicities
Yamamoto, B. K., Moszczyńska, A., & Gudelsky, G. A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05141.x · Cited by 283 · see citing works
Cold pressor stress impairs performance on working memory tasks requiring executive functions in healthy young men.
Schoofs, D., Wolf, O. T., & Smeets, T. (2009) · Behavioral Neuroscience · doi:10.1037/a0016980 · Cited by 269 · see citing works
Role of kappa-opioid receptors in stress and anxiety-related behavior
Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 254 · see citing works
The pig as an animal model for human pathologies: A proteomics perspective
Bassols, A., Costa, C., Eckersall, P. D., Osada, J., Sabrià, J., & Tibau, J. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201300099 · Cited by 256 · see citing works
Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders
Conio, B., Martino, M., Magioncalda, P., Escelsior, A., Inglese, M., Amore, M., & Northoff, G. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0406-4 · Cited by 254 · see citing works
The role of the locus coeruleus in the generation of pathological anxiety
Morris, L. S., McCall, J. G., Charney, D. S., & Murrough, J. W. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820930321 · Cited by 224 · see citing works
Lack of functional estrogen receptor β influences anxiety behavior and serotonin content in female mice
Imwalle, D. B., Gustafsson, J.-Α., & Rissman, E. F. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.11.002 · Cited by 225 · see citing works
Both oxytocin and vasopressin may influence alloparental behavior in male prairie voles
Bales, K. L., Kim, A. J., Lewis-Reese, A. D., & Sue Carter, C. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.01.004 · Cited by 217 · see citing works
Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal
Scavone, J. L., Sterling, R. C., & Van Bockstaele, E. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.034 · Cited by 209 · see citing works
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198 · see citing works
Stress, female reproduction and pregnancy
Valsamakis, G., Chrousos, G. P., & Mastorakos, G. P. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.031 · Cited by 189 · see citing works
Ergonomic human-robot collaboration in industry: A review
Lorenzini, M., Lagomarsino, M., Fortini, L., Gholami, S., & Ajoudani, A. (2023) · Frontiers in Robotics and AI · doi:10.3389/frobt.2022.813907 · Cited by 186 · see citing works
Interactions between NPY and CRF in the amygdala to regulate emotionality
Sajdyk, T. J., Shekhar, A., & Gehlert, D. R. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.05.006 · Cited by 183 · see citing works
High trait anxiety in healthy subjects is associated with low neuroendocrine activity during psychosocial stress
Ježová, D., Makatsori, A., Dunčko, R., Moncek, F., & Jakubek, M. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.08.005 · Cited by 175 · see citing works
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
What Turns on a Migraine? A Systematic Review of Migraine Precipitating Factors
Peroutka, S. J. (2014) · Current Pain and Headache Reports · doi:10.1007/s11916-014-0454-z · Cited by 170 · see citing works
A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration
Tavakoli, P., Vollmer-Conna, U. S., Hadzi-Pavlovic, D., & Grimm, M. (2021) · Public health reviews · doi:10.3389/phrs.2021.1603990 · Cited by 173 · see citing works
Magnesium Status and Stress: The Vicious Circle Concept Revisited
Pickering, G. P., Mazur, A., Trousselard, M., Bieńkowski, P., Yaltsewa, N., Amessou, M., Noah, L., & Pouteau, E. B. (2020) · Nutrients · doi:10.3390/nu12123672 · Cited by 183 · see citing works
The effects of intensive, long-term treadmill running on reproductive hormones, hypothalamus–pituitary–testis axis, and semen quality: a randomized controlled study
Safarinejad, M. R., Azma, K., & Kolahi, A. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0477 · Cited by 162 · see citing works
Retracted
Association of low blood pressure with anxiety and depression: the Nord-Trøndelag Health Study
Hildrum, B., Mykletun, A., Stordal, E., Bjelland, I., Dahl, A. A., & Holmen, J. (2006) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2005.044966 · Cited by 162 · see citing works
Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction
Liu, X., Betzenhauser, M. J., Reiken, S. R., Méli, A. C., Xie, W., Chen, B.-X., Arancio, O., & Marks, A. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.052 · Cited by 161 · see citing works
Stress-Induced Visceral Pain: Toward Animal Models of Irritable-Bowel Syndrome and Associated Comorbidities
Moloney, R. D., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00015 · Cited by 167 · see citing works
Modulation of immune responses in stress by Yoga
Arora, S., & Bhattacharjee, J. (2008) · International Journal of Yoga · doi:10.4103/0973-6131.43541 · Cited by 167 · see citing works
Interactions between Temperament, Stress, and Immune Function in Cattle
Sanchez, N. C. B., Randel, R. D., Carroll, J. A., & Welsh, T. H. (2011) · International Journal of Zoology · doi:10.1155/2011/373197 · Cited by 153 · see citing works
Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats
Grippo, A. J., Sullivan, N. R., Damjanoska, K. J., Crane, J. W., Carrasco, G. A., Shi, J., Chen, Z., García, F., Muma, N. A., & de Kar, L. D. V. (2004) · Psychopharmacology · doi:10.1007/s00213-004-2103-4 · Cited by 153 · see citing works
Self-citation
Studies on the neuroendocrine role of serotonin.
Jørgensen, H. S. (2007) · PubMed · Cited by 144 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b Receptors
Lolait, S. J., Stewart, L. Q., Jessop, D. S., Young, W. S., & O’Carroll, A. (2006) · Endocrinology · doi:10.1210/en.2006-1309 · Cited by 146 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Collateralized dorsal raphe nucleus projections: A mechanism for the integration of diverse functions during stress
Waselus, M., Valentino, R. J., & Van Bockstaele, E. J. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.011 · Cited by 142 · see citing works
New roles for estrogen receptor β in behavior and neuroendocrinology☆
Bodo, C., & Rissman, E. F. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.02.004 · Cited by 141 · see citing works
Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 137 · see citing works
Strength in diversity: Understanding the pathways to herpes simplex virus reactivation
Suzich, J. B., & Cliffe, A. R. (2018) · Virology · doi:10.1016/j.virol.2018.07.011 · Cited by 136 · see citing works
Plasma concentrations of substance P and cortisol in beef calves after castration or simulated castration
Coetzee, J. F., Lubbers, B. V., Toerber, S., Gehring, R., Thomson, D. U., White, B. J., & Apley, M. D. (2008) · American Journal of Veterinary Research · doi:10.2460/ajvr.69.6.751 · Cited by 136 · see citing works
Chronic blockade of cannabinoid CB2receptors induces anxiolytic‐like actions associated with alterations in GABAAreceptors
García‐Gutiérrez, M. S., García‐Bueno, B., Zoppi, S., Leza, J. C., & Manzanares, J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01625.x · Cited by 136 · see citing works
A review on animal models for screening potential anti-stress agents
Jaggi, A. S., Bhatia, N., Kumar, N., Singh, N., Anand, P., & Dhawan, R. K. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0770-6 · Cited by 134 · see citing works
Stress physiology in marine mammals: how well do they fit the terrestrial model?
Atkinson, S., Crocker, D. E., Houser, D., & Mashburn, K. (2015) · Journal of Comparative Physiology □ B · doi:10.1007/s00360-015-0901-0 · Cited by 126 · see citing works
Sepsis-induced brain dysfunction
Adam, N., Kandelman, S., Mantz, J., Chrétien, F. C., & Sharshar, T. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.159 · Cited by 131 · see citing works
Can Stress in Farm Animals Increase Food Safety Risk?
Rostagno, M. H. (2009) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2009.0315 · Cited by 132 · see citing works
Borderline personality disorder: Hypothalamus pituitary adrenal axis and findings from neuroimaging studies
Wingenfeld, K., Spitzer, C., Rullkötter, N., & Löwe, B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.014 · Cited by 126 · see citing works
Biogenic Amines: Signals Between Commensal Microbiota and Gut Physiology
Sudo, N. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00504 · Cited by 130 · see citing works
Stress-induced increase of testosterone: contributions of social status and sympathetic reactivity
Chichinadze, K., & Chichinadze, N. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.03.020 · Cited by 126 · see citing works
Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress
Perusini, J. N., Meyer, E. M., Long, V., Rau, V., Nocera, N. A., Avershal, J., Maksymetz, J., Spigelman, I., & Fanselow, M. S. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.224 · Cited by 128 · see citing works
The role of vitamin C in stress-related disorders
Moritz, B., Schmitz, A. E., Rodrigues, A. L. S., Dafré, A. L., & Cunha, M. P. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108459 · Cited by 133 · see citing works
Endocrine Basis for Disruptive Effects of Cortisol on Preovulatory Events
Breen, K. M., Billings, H. J., Wagenmaker, E. R., Wessinger, E. W., & Karsch, F. J. (2005) · Endocrinology · doi:10.1210/en.2004-1457 · Cited by 126 · see citing works
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
Lukkes, J. L., Forster, G. L., Renner, K. J., & Summers, C. H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.024 · Cited by 126 · see citing works
Love is more than just a kiss: a neurobiological perspective on love and affection
de Boer, A., van Buel, E. M., & Ter Horst, G. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.017 · Cited by 123 · see citing works
Corticotropin‐releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity
Forster, G. L., Pringle, R. B., Mouw, N. J., Vuong, S. M., Watt, M. J., Burke, A. R., Lowry, C. A., Summers, C. H., & Renner, K. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06333.x · Cited by 125 · see citing works
The effect of lead intoxication on endocrine functions
Doumouchtsis, K., Doumouchtsis, S. K., Doumouchtsis, E. K., & Perrea, D. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345710 · Cited by 128 · see citing works
Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats
Sheikh, N., Ahmad, A., Siripurapu, K. B., Kuchibhotla, V. K., Singh, S., & Palit, G. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.01.025 · Cited by 124 · see citing works
Evolution of secretin family GPCR members in the metazoa
Cardoso, J. C. R., Pinto, V., Vieira, F. A., Clark, M. S., & Power, D. M. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-108 · Cited by 123 · see citing works
Sensitivity to stress: Dysregulation of CRF pathways and disease development
Bale, T. L. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.01.009 · Cited by 122 · see citing works
Serotonin Coordinates Responses to Social Stress—What We Can Learn from Fish
Backström, T., & Winberg, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00595 · Cited by 111 · see citing works
Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction
Sauzeau, V., Sevilla, M. A., Rivas‐Elena, J. V., de Álava, E., Montero, M. J., López-Novoa, J. M., & Bustelo, X. R. (2006) · Nature Medicine · doi:10.1038/nm1426 · Cited by 121 · see citing works
Neurobiological adaptations to violence across development
Mead, H. K., Beauchaine, T. P., & Shannon, K. E. (2010) · Development and Psychopathology · doi:10.1017/s0954579409990228 · Cited by 120 · see citing works
Animal models in translational studies of PTSD
Daskalakis, N. P., Yehuda, R., & Diamond, D. M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.006 · Cited by 116 · see citing works
Brain and cardiovascular diseases: common neurogenic background of cardiovascular, metabolic and inflammatory diseases.
Szczepanska‐Sadowska, E. K., Cudnoch‐Jędrzejewska, A., Ufnal, M., & Żera, T. (2010) · PubMed · Cited by 116 · see citing works
Modulation of the serotonin system by endocannabinoid signaling
Haj‐Dahmane, S., & Shen, R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.016 · Cited by 117 · see citing works
The Role of Psychological Stress in Inflammatory Bowel Disease
Mawdsley, J. E. D., & Rampton, D. S. (2006) · NeuroImmunoModulation · doi:10.1159/000104861 · Cited by 116 · see citing works
The vasopressin Avpr1b receptor: Molecular and pharmacological studies
Roper, J. A., O'Carroll, A.-M., Young, W. S., & Lolait, S. (2010) · Stress · doi:10.3109/10253890.2010.512376 · Cited by 116 · see citing works
Interactions of Chronic Lead Exposure and Intermittent Stress: Consequences for Brain Catecholamine Systems and Associated Behaviors and HPA Axis Function
Virgolini, M. B., Chen, K. Y., Weston, D. D., Bauter, M. R., & Cory‐Slechta, D. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi269 · Cited by 115 · see citing works
GABAB receptor is a novel drug target for pancreatic cancer
Schuller, H. M., Al-Wadei, H. A. N., & Majidi, M. (2007) · Cancer · doi:10.1002/cncr.23231 · Cited by 114 · see citing works
HPA Axis Alterations in Mental Disorders: Impact on Memory and its Relevance for Therapeutic Interventions
Wingenfeld, K., & Wolf, O. T. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00207.x · Cited by 113 · see citing works
Science review: The brain in sepsis--culprit and victim.
Sharshar, T., Hopkinson, N. S., Orlikowski, D., & Annane, D. (2004) · Critical Care · doi:10.1186/cc2951 · Cited by 113 · see citing works
Targeting the gut to treat multiple sclerosis
Ghezzi, L., Cantoni, C., Pinget, G. V., Zhou, Y., & Piccio, L. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143774 · Cited by 114 · see citing works
Influence of chronic stress on brain corticosteroid receptors and HPA axis activity
Gądek-Michalska, A., Spyrka, J., Rachwalska, P., Tadeusz, J., & Bugajski, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71474-9 · Cited by 110 · see citing works
Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems
Becker, S., & Schweinhardt, P. (2011) · Pain Research and Treatment · doi:10.1155/2012/741746 · Cited by 111 · see citing works
Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management
Gros, M., Gros, B., Mesonero, J. E., & Latorre, E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153429 · Cited by 117 · see citing works
Repeated Lipopolysaccharide (LPS) or Cytokine Treatments Sensitize Ethanol Withdrawal-Induced Anxiety-Like Behavior
Breese, G. R., Knapp, D. J., Overstreet, D. H., Navarro, M., Wills, T. A., & Angel, R. A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301468 · Cited by 110 · see citing works
Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor
Gehlert, D. R., Shekhar, A., Morin, S. M., Hipskind, P. A., Zink, C., Gackenheimer, S. L., Shaw, J., Fitz, S. D., & Sajdyk, T. J. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.12.030 · Cited by 110 · see citing works
Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats
Lee, B., Shim, I., Lee, H., Yang, Y. D., & Hahm, D. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.076 · Cited by 109 · see citing works
A Centrally Acting, Anxiolytic Angiotensin II AT1 Receptor Antagonist Prevents the Isolation Stress-Induced Decrease in Cortical CRF1 Receptor and Benzodiazepine Binding
Saavedra, J. M., Armando, I., Bregonzio, C., Juorio, A. V., Macova, M., Pavel, J., & Sánchez-Lemus, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300921 · Cited by 109 · see citing works
Effects of continuously enhanced corticotropin releasing factor expression within the bed nucleus of the stria terminalis on conditioned and unconditioned anxiety
Sink, K. S., Walker, D. L., Freeman, S. M., Flandreau, E. I., Ressler, K. J., & Davis, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.188 · Cited by 108 · see citing works

Effect of insulin on brain 5-hydroxytryptamine and 5-hydroxy-indole-acetic acid of rat
Gordon, A. E., & Meldrum, B. S. (1970) · Biochemical Pharmacology · doi:10.1016/0006-2952(70)90091-2 · Cited by 37 · see citing works
Neuroendocrine Correlates of Stress
McKerns, K. W., & Pantić, V. R. (1985) · Springer eBooks · doi:10.1007/978-1-4684-8553-0 · Cited by 10 · see citing works
Forebrain Pathways Mediating Stress-Induced Hormone Secretion
de Kar, L. D. V., & Blair, M. L. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0172 · Cited by 380 · see citing works
Glucocorticoids, Transmitters and Stress
Delbende, C., Delarue, C., Lefèbvre, H., Bunel, D. T., SZAFARCZYK, A., Mocaër, E., Kamoun, A., Jégou, S., & Vaudry, H. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000296657 · Cited by 89 · see citing works
Stress, Neuropeptides, and Systemic Disease
Ayd, F. J. (1991) · JAMA · doi:10.1001/jama.1991.03470020108044 · Cited by 45 · see citing works

Authors: Carrasco, G. A., & Van de Kar, L. D.
Affiliations: Loyola University Chicago (US)
ORCID: Carrasco, Gonzalo A
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2003-02
Volume: 463
Issue: 1-3
Pages: 235-272
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/s0014-2999(03)01285-8
OpenAlex: W1971277989
Cited by: 914
References: 656
Citations by year: 2026: 7 · 2025: 11 · 2024: 24 · 2023: 27 · 2022: 29 · 2021: 37 · 2020: 32 · 2019: 30 · 2018: 36 · 2017: 27 · 2016: 36 · 2015: 34 · 2014: 43 · 2013: 64 · 2012: 49
FWCI: 21.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA013669, DA 13669)
National Institute of Neurological Disorders and Stroke (NS34153)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords: stress response, neuroendocrine regulation, corticotropin-releasing factor, vasopressin, renin-angiotensin system, hypothalamic-pituitary-adrenal axis, catecholamines, serotonin, substance P, vasoactive intestinal peptide, neuropeptide Y, cholecystokinin, benzodiazepines, anxiolytics, antidepressants, anxiety disorders, glucocorticoids, ACTH, sympathetic nervous system, adrenal medulla
MeSH terms: Amygdala, Animals, Brain Chemistry, Endocrine System, Humans, Hypothalamus, Neurosecretory Systems, Stress, Physiological, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroendocrine pharmacology of stress

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks