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Cited by 986

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Cell fate determination in the vertebrate retina.

Open access
Cepko, C L, Austin, C P, Yang, X, Alexiades, M, Ezzeddine, D·1996·Proceedings of the National Academy of Sciences

Abstract

In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.

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Metadata

Authors
Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M., & Ezzeddine, D.
Venue
Proceedings of the National Academy of Sciences
Published
1996-01-23
Volume
93
Issue
2
Pages
589-595
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2066556283
Cited by
986
References
0
FWCI
9.52
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Cell fate determination in the vertebrate retina. https://app.cochat.ai/papers/10.1073/pnas.93.2.589
The paper
Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M., & Ezzeddine, D. (1996). Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.2.589

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.