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Cell fate determination in the vertebrate retina.
Open accessAbstract
In the vertebrate central nervous system, the retina has been a useful model for studies of cell fate determination. Recent results from studies conducted in vitro and in vivo suggest a model of retinal development in which both the progenitor cells and the environment change over time. The model is based upon the notion that the mitotic cells within the retina change in their response properties, or "competence", during development. These changes presage the ordered appearance of distinct cell types during development and appear to be necessary for the production of the distinct cell types. As the response properties of the cells change, so too do the environmental signals that the cells encounter. Together, intrinsic properties and extrinsic cues direct the choice of cell fate.
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Citations
Cited by
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
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Zhong, X., Gutierrez, C., Xue, T., Hampton, C., Vergara, M. N., Cao, L.-H., Peters, A., Park, T. S., Zambidis, E. T., Meyer, J. S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5047 · Cited by 970
Nrl is required for rod photoreceptor development
Mears, A. J., Kondo, M., Swain, P. K., Takada, Y., Bush, R. A., Saunders, T. L., Sieving, P. A., & Swaroop, A. (2001) · Nature Genetics · doi:10.1038/ng774 · Cited by 912
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
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Ng, L., Hurley, J. B., Dierks, B., Srinivas, M., Saltó, C., Vennström, B., Reh, T. A., & Forrest, D. (2001) · Nature Genetics · doi:10.1038/83829 · Cited by 561
Metadata
- Authors
- Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M., & Ezzeddine, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-01-23
- Volume
- 93
- Issue
- 2
- Pages
- 589-595
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066556283
- Cited by
- 986
- References
- 0
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cell fate determination in the vertebrate retina. https://app.cochat.ai/papers/10.1073/pnas.93.2.589
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- Cepko, C. L., Austin, C. P., Yang, X., Alexiades, M., & Ezzeddine, D. (1996). Cell fate determination in the vertebrate retina. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.2.589
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.