The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
Open accessAbstract
The stress-activated protein kinases JNK and p38 mediate increased gene expression and are activated by environmental stresses and proinflammatory cytokines. Using an in vivo model in which oxidative stress is generated in the liver by intracellular metabolism, rapid protein–DNA complex formation on stress-activated AP-1 target genes was observed. Analysis of the induced binding complexes indicates that c-fos, c-jun, and ATF-2 were present, but also two additional jun family members, JunB and JunD. Activation of JNK precedes increased AP-1 DNA binding. Furthermore, JunB was shown to be a substrate for JNK, and phosphorylation requires the N-terminal activation domain. Unexpectedly, p38 activity was found to be constitutively active in the liver and was down-regulated through selective dephosphorylation following oxidative stress. One potential mechanism for p38 dephosphorylation is the rapid stress-induced activation of the phosphatase MKP-1, which has high affinity for phosphorylated p38 as a substrate. These data demonstrate that there are mechanisms for independent regulation of the JNK and p38 mitogen-activated protein kinase signal transduction pathways after metabolic oxidative stress in the liver.
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Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555
Self-citationThe jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) · Cell · doi:10.1016/0092-8674(93)90383-2 · Cited by 1,156
Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642
Self-citationAlessi, D. R., Gomez, N., Moorhead, G., Lewis, T., Keyse, S. M., & Cohen, P. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00059-5 · Cited by 365
Cited by
Mielke, K., & Herdegen, T. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00042-8 · Cited by 490
Jiang, Y., Gram, H., Zhao, M., New, L., Gu, J., Feng, L., Di Padova, F., Ulevitch, R. J., & Han, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30122 · Cited by 489
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH 2 -terminal kinase
Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T., & Davis, R. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7337 · Cited by 379
Self-citationThe plasminogen activator system: biology and regulation
Irigoyen, J. P., Muñoz-Cánoves, P., Montero, L., Koziczak, M., & Nagamine, Y. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000615 · Cited by 368
NFκB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells
Zhou, L. Z.-H., Johnson, A. P., & Rando, T. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00719-5 · Cited by 326
Metadata
- Authors
- Mendelson, K. G., Contois, L.-R., Tevosian, S. G., Davis, R. J., & Paulson, K. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 12908-12913
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985789399
- Cited by
- 234
- References
- 6
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. https://app.cochat.ai/papers/10.1073/pnas.93.23.12908
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- Mendelson, K. G., Contois, L.-R., Tevosian, S. G., Davis, R. J., & Paulson, K. E. (1996). Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.23.12908
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
