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Activation of mouse sperm T-type Ca 2+ channels by adhesion to the egg zona pellucida
Open accessAbstract
The sperm acrosome reaction is a Ca 2+ -dependent exocytotic event that is triggered by adhesion to the mammalian egg’s zona pellucida. Previous studies using ion-selective fluorescent probes suggested a role of voltage-sensitive Ca 2+ channels in acrosome reactions. Here, whole-cell patch clamp techniques are used to demonstrate the expression of functional T-type Ca 2+ channels during mouse spermatogenesis. The germ cell T current is inhibited by antagonists of T-type channels (pimozide and amiloride) as well as by antagonists whose major site of action is the somatic cell L-type Ca 2+ channel (1,4-dihydropyridines, arylalkylamines, benzothiazapines), as has also been reported for certain somatic cell T currents. In sperm, inhibition of T channels during gamete interaction inhibits zona pellucida-dependent Ca 2+ elevations, as demonstrated by ion-selective fluorescent probes, and also inhibits acrosome reactions. These studies directly link sperm T-type Ca 2+ channels to fertilization. In addition, the kinetics of channel inhibition by 1,4-dihydropyridines suggests a mechanism for the reported contraceptive effects of those compounds in human males.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
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A sperm ion channel required for sperm motility and male fertility
Ren, D., Navarro, B., Perez, G., Jackson, A. C., Hsu, S., Shi, Q., Tilly, J. L., & Clapham, D. E. (2001) · Nature · doi:10.1038/35098027 · Cited by 957
Mussel Adhesive Protein Mimetic Polymers for the Preparation of Nonfouling Surfaces
Dalsin, J. L., Hu, B.-H., Lee, B. P., & Messersmith, P. B. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0284963 · Cited by 585
Metadata
- Authors
- Arnoult, C., Cardullo, R. A., Lemos, J. R., & Florman, H. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-12
- Volume
- 93
- Issue
- 23
- Pages
- 13004-13009
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072219354
- Cited by
- 227
- References
- 2
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Arnoult, C., Cardullo, R. A., Lemos, J. R., & Florman, H. M. (1996). Activation of mouse sperm T-type Ca 2+ channels by adhesion to the egg zona pellucida. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.23.13004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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