Multiple types of neuronal calcium channels and their selective modulation
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During synaptic activity, transient Ca2+ influx affects glutamate receptor trafficking, cytoskeletal remodeling, and local protein synthesis through activation of kinases, phosphatases, and transcription factors PGC-1α and CREB.
“During synaptic activity, the transient Ca2+ influx affects glutamate receptor trafficking, cytoskeletal remodeling, and local protein synthesis through activation of cytosolic kinases, phosphatases, and the major neuronal transcription factors, including PGC-1α and cyclic AMP response element-binding protein (CREB) (Mattson and Arumugam, 2018; Tsien et al., 1988).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Tsien et al., 1988
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- Authors
- Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P.
- Affiliations
- Yale University (US)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 11
- Issue
- 10
- Pages
- 431-438
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2068617048
- Cited by
- 1,381
- References
- 80
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 19 · 2014: 19 · 2013: 16 · 2012: 14
- FWCI
- 12.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- voltage-gated calcium channels, calcium channel subtypes, channel gating, ionic conductance, channel pharmacology, calcium channel modulation, neurochemical regulation
- MeSH terms
- Action Potentials, Animals, Membrane Potentials, Neurons, Calcium Channels
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