The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
TOR2 is required for organization of the actin cytoskeleton in yeast
Open accessAbstract
The Saccharomyces cerevisiae gene TOR2 encodes a putative phosphatidylinositol kinase that has two essential functions. One function is redundant with TOR1, a TOR2 homolog, and is required for signaling translation initiation and early G 1 progression. The second essential function is unique to TOR2. Here we report that loss of the TOR2-unique function disrupts polarized distribution of the actin cytoskeleton. A screen for dosage suppressors of a dominant negative TOR2 allele identified TCP20/CCT6 , encoding a subunit of the cytosolic chaperonin TCP-1 that is involved in the biogenesis of actin structures. Overexpression of TCP20 restores growth and polarized distribution of the actin cytoskeleton in a tor2 mutant. TCP20 overexpression does not restore growth in a tor1 tor2 double mutant. We suggest that the unique function of the phosphatidylinositol kinase homolog TOR2 is required for signaling organization of the actin cytoskeleton during the cell cycle. TOR2, via its two functions, may thus integrate temporal and spatial control of cell growth.
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Cites
The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo
Sternlicht, H., Farr, G. W., Sternlicht, M. L., Driscoll, J. K., Willison, K., & Yaffe, M. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9422 · Cited by 341
Cited by
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
TOR, a Central Controller of Cell Growth
Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,924
Self-citationLoewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886
Self-citationMolecular evidence for an ancient duplication of the entire yeast genome
Wolfe, K. H., & Shields, D. C. (1997) · Nature · doi:10.1038/42711 · Cited by 1,785
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Metadata
- Authors
- Schmidt, A., Kunz, J., & Hall, M. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-11-26
- Volume
- 93
- Issue
- 24
- Pages
- 13780-13785
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005188492
- Cited by
- 262
- References
- 1
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Schmidt, A., Kunz, J., & Hall, M. N. (1996). TOR2 is required for organization of the actin cytoskeleton in yeast. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.24.13780
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
