Cited by 1,785Chromosomal and Genetic VariationsFungal and yeast genetics researchGenome Rearrangement Algorithms

Molecular evidence for an ancient duplication of the entire yeast genome

Wolfe, Kenneth H., Shields, Denis C.·1997·Nature

Abstract

Gene duplication is an important source of evolutionary novelty. Most duplications are of just a single gene, but Ohno proposed that whole-genome duplication (polyploidy) is an important evolutionary mechanism. Many duplicate genes have been found in Saccharomyces cerevisiae, and these often seem to be phenotypically redundant. Here we show that the arrangement of duplicated genes in the S. cerevisiae genome is consistent with Ohno's hypothesis. We propose a model in which this species is a degenerate tetraploid resulting from a whole-genome duplication that occurred after the divergence of Saccharomyces from Kluyveromyces. Only a small fraction of the genes were subsequently retained in duplicate (most were deleted), and gene order was rearranged by many reciprocal translocations between chromosomes. Protein pairs derived from this duplication event make up 13% of all yeast proteins, and include pairs of transcription factors, protein kinases, myosins, cyclins and pheromones. Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces.

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Authors
Wolfe, K. H., & Shields, D. C.
Affiliations
Trinity College Dublin (IE)
Corresponding author
Wolfe, Kenneth H.
Venue
Nature
Published
1997-06-12
Volume
387
Issue
6634
Pages
708-713
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1641544182
Cited by
1,785
References
1
Citations by year
2026: 21 · 2025: 28 · 2024: 36 · 2023: 42 · 2022: 41 · 2021: 55 · 2020: 53 · 2019: 50 · 2018: 45 · 2017: 63 · 2016: 53 · 2015: 48 · 2014: 80 · 2013: 69 · 2012: 83
FWCI
91.59
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • Wellcome Trust
  • European Commission
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
Keywords
whole-genome duplication, polyploidy, Saccharomyces cerevisiae, tetraploidy, gene duplication, gene order, reciprocal translocation, duplicate gene retention, gene deletion, transcription factors, protein kinases, myosin, cyclins, pheromones, anaerobic fermentation
MeSH terms
Multigene Family, Kluyveromyces, Models, Genetic, Phylogeny, Ploidies, Saccharomyces cerevisiae, Chromosomes, Fungal, Genome, Fungal, Evolution, Molecular

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