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Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins.
Open accessAbstract
The consequences of Helicobacter pylori attachment to human gastric cells were examined by transmission electron microscopy and immunofluorescence microscopy. H. pylori attachment resulted in (i) effacement of microvilli at the site of attachment, (ii) cytoskeletal rearrangement directly beneath the bacterium, and (iii) cup/pedestal formation at the site of attachment. Double-immunofluorescence studies revealed that the cytoskeletal components actin, alpha-actinin, and talin are involved in the process. Immunoblot analysis showed that binding of H. pylori to AGS cells induced tyrosine phosphorylation of two host cell proteins of 145 and 105 kDa. These results indicate that attachment of H. pylori to gastric epithelial cells resembles that of enteropathogenic Escherichia coli. Coccoid H. pylori, which are thought to be terminally differentiated bacterial forms, are capable of binding and inducing cellular changes of the same sort as spiral H. pylori, including tyrosine phosphorylation of host proteins.
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Citations
Cited by
Helicobacter pylori Virulence and Genetic Geography
Covacci, A., Telford, J. L., Giudice, G. D., Parsonnet, J., & Rappuoli, R. (1999) · Science · doi:10.1126/science.284.5418.1328 · Cited by 1,049
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Segal, E. D., Cha, J., Lo, J., Falkow, S., & Tompkins, L. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14559 · Cited by 770
Self-citationHost-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Atherton, J. C. (2006) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100125 · Cited by 567
Metadata
- Authors
- Segal, E. D., Falkow, S., & Tompkins, L. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-02-06
- Volume
- 93
- Issue
- 3
- Pages
- 1259-1264
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069639258
- Cited by
- 281
- References
- 0
- FWCI
- 24.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Segal, E. D., Falkow, S., & Tompkins, L. S. (1996). Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.3.1259
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