The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES
Abstract
Helicobacter pylori is the main cause of peptic ulceration, distal gastric adenocarcinoma, and gastric lymphoma. Only 15% of those colonized develop disease, and pathogenesis depends upon strain virulence, host genetic susceptibility, and environmental cofactors. Virulence factors include the cag pathogenicity island, which induces proinflammatory, pro-proliferative epithelial cell signaling; the cytotoxin VacA, which causes epithelial damage; and an adhesin, BabA. Host genetic polymorphisms that lead to high-level pro-inflammatory cytokine release in response to infection increase cancer risk. Pathogenesis is dependent upon inflammation, a Th-1 acquired immune response and hormonal changes including hypergastrinaemia. Antral-predominant inflammation leads to increased acid production from the uninflamed corpus and predisposes to duodenal ulceration; corpus-predominant gastritis leads to hypochlorhydria and predisposes to gastric ulceration and adenocarcinoma. Falling prevalence of H. pylori in developed countries has led to a falling incidence of associated diseases. However, whether there are disadvantages of an H. pylori-free stomach, for example increased risk of esosphageal adenocarcinoma, remains unclear.
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LAURÉN, P. (1965) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/apm.1965.64.1.31 · Cited by 6,133
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, K. E. L., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C., Rothman, N., et al. (2000) · Nature · doi:10.1038/35006081 · Cited by 2,366
Wotherspoon, A. C., Diss, T. C., Pan, L., Isaacson, P. G., Doglioni, C., Moschini, A., & de Boni, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91409-f · Cited by 2,118
Alm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., et al. (1999) · Nature · doi:10.1038/16495 · Cited by 1,893
Censini, S., Lange, C., Xiang, Z., Crabtree, J. E., Ghiara, P., Borodovsky, M., Rappuoli, R., & Covacci, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14648 · Cited by 1,872
Blaser, M. J., Perez-Perez, G. I., Kleanthous, H., Cover, T. L., Peek, R. M., Chyou, P.-H., Stemmermann, G. N., & Nomura, A. M. Y. (1995) · PubMed · Cited by 1,608
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
Girardin, S. E., Boneca, I. G., Carneiro, L. A. M., Antignac, A., Jéhanno, M., Viala, J., Tedin, K., Taha, M.-K., Labigne, A., Zäthringer, U., et al. (2003) · Science · doi:10.1126/science.1084677 · Cited by 1,577
Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori
Atherton, J. C., Cao, P., Peek, R. M., Tummuru, M. K. R., Blaser, M. J., & Cover, T. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17771 · Cited by 1,566
Self-citationWong, B. C.-Y., Lam, S. K., Wong, W. M., Chen, J. S., Zheng, T. T., Feng, R. E., Lai, K. C., Hu, W. H. C., Yuen, S. T., Leung, S. Y., et al. (2004) · JAMA · doi:10.1001/jama.291.2.187 · Cited by 1,435
Cited by
Recent patterns in gastric cancer: A global overview
Bertuccio, P., Chatenoud, L., Levi, F., Praud, D., Ferlay, J., Negri, E., Malvezzi, M., & La Vecchia, C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24290 · Cited by 624
Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori
Park, A.-M., Hagiwara, S., Hsu, D. K., Liu, F.-T., & Yoshie, O. (2016) · Infection and Immunity · doi:10.1128/iai.01299-15 · Cited by 67
Liu, H., Rahman, A., Semino-Mora, C., Doi, S. Q., & Dubois, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002689 · Cited by 44
Alpízar‐Alpízar, W., Nielsen, B. S., Sierra, R., Illemann, M., Ramírez, J. A., Arias, A., Durán, S., Skarstein, A., Ovrebo, K., Lund, L. R., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.24755 · Cited by 36
Metadata
- Authors
- Atherton, J. C.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2006-02-01
- Volume
- 1
- Issue
- 1
- Pages
- 63-96
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2135443167
- Cited by
- 567
- References
- 215
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES. https://app.cochat.ai/papers/10.1146/annurev.pathol.1.110304.100125
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- Atherton, J. C. (2006). THE PATHOGENESIS OF HELICOBACTER PYLORI–INDUCED GASTRO-DUODENAL DISEASES. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev.pathol.1.110304.100125
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