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Expression of the fructose transporter GLUT5 in human breast cancer.
Open accessAbstract
The primary metabolic characteristic of malignant cells is an increased uptake of glucose and its anaerobic metabolism. We studied the expression and function of the glucose transporters in human breast cancer cell lines and analyzed their expression in normal and neoplastic primary human breast tissue. Hexose uptake assays and immunoblotting experiments revealed that the breast carcinoma cell lines MCF-7 and MDA-468 express the glucose transporters GLUT1 and GLUT2, isoforms expressed in both normal and neoplastic breast tissue. We also found that the breast cancer cell lines transport fructose and express the fructose transporter GLUT5. Immunolocalization studies revealed that GLUT5 is highly expressed in vivo in human breast cancer but is absent in normal human breast tissue. These findings indicate that human breast cancer cells have a specialized capacity to transport fructose, a metabolic substrate believed to be used by few human tissues. Identification of a high-affinity fructose transporter on human breast cancer cells opens opportunities to develop novel strategies for early diagnosis and treatment of breast cancer.
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Cites
Over-expression of facilitative glucose transporter genes in human cancer
Yamamoto, T., Seino, Y., Fukumoto, H., Koh, G., Yano, H., Inagaki, N., Yamada, Y., Inoue, K., Manabe, T., & Imura, H. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91263-r · Cited by 465
Cited by
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
Macheda, M. L., Rogers, S., & Best, J. D. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20166 · Cited by 1,229
Functional Properties and Genomics of Glucose Transporters
Zhao, F.-Q., & Keating, A. (2007) · Current Genomics · doi:10.2174/138920207780368187 · Cited by 549
Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment
Barron, C. C., Bilan, P. J., Tsakiridis, T., & Tsiani, E. (2016) · Metabolism · doi:10.1016/j.metabol.2015.10.007 · Cited by 435
Keshari, K. R., & Wilson, D. M. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60124b · Cited by 358
Airley, R. E., & Mobasheri, A. (2007) · Chemotherapy · doi:10.1159/000104457 · Cited by 342
Metadata
- Authors
- Zamora-León, S. P., Golde, D. W., Concha, I. I., Rivas, C. I., Delgado-López, F., Baselga, J., Nualart, F., & Vera, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-03-05
- Volume
- 93
- Issue
- 5
- Pages
- 1847-1852
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097687227
- Cited by
- 212
- References
- 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Zamora-León, S. P., Golde, D. W., Concha, I. I., Rivas, C. I., Delgado-López, F., Baselga, J., Nualart, F., & Vera, J. C. (1996). Expression of the fructose transporter GLUT5 in human breast cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.5.1847
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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