The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
Open accessAbstract
In the last few years, data from experiments employing transgenic models of autoimmune disease have strengthened a particular concept of autoimmunity: disease results not so much from cracks in tolerance induction systems, leading to the generation of anti-self repertoire, as from the breakdown of secondary systems that keep these cells in check. T cells with anti-self specificities are readily found in disease-free individuals but ignore target tissues. This is also the case in some transgenic models, in spite of overwhelming numbers of autoreactive cells. In other instances, local infiltration and inflammation result, but they are well tolerated for long periods of time and do not terminally destroy target tissue. We review the possible molecular and cellular mechanisms that underlie these situations, with a particular emphasis on the destruction of pancreatic beta cells in transgenic models of insulin-dependent disease.
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Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
Shull, M. M., Ormsby, I., Kier, A. B., Pawlowski, S., Diebold, R. J., Yin, M., Allen, R., Sidman, C., Proetzel, G., Calvin, D., et al. (1992) · Nature · doi:10.1038/359693a0 · Cited by 2,985
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., & Mak, T. W. (1995) · Science · doi:10.1126/science.270.5238.985 · Cited by 2,766
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Breeding of a Non-Obese, Diabetic Strain of Mice
MAKINO, S., KUNIMOTO, K., MURAOKA, Y., MIZUSHIMA, Y., KATAGIRI, K., & TOCHINO, Y. (1980) · Experimental Animals · doi:10.1538/expanim1978.29.1_1 · Cited by 1,249
Ohashi, P. S., Oehen, S., Buerki, K., Pircher, H., Ohashi, C. T., Odermatt, B., Malissen, B., Zinkernagel, R. M., & Hengartner, H. (1991) · Cell · doi:10.1016/0092-8674(91)90164-t · Cited by 1,173
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
Liblau, R. S., Singer, S. M., & McDevitt, H. O. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80068-9 · Cited by 1,105
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A., & Alt, F. W. (1995) · Immunity · doi:10.1016/1074-7613(95)90180-9 · Cited by 1,080
The Pathogenesis of Insulin-Dependent Diabetes Mellitus
Epstein, F. H., Atkinson, M. A., & Maclaren, N. K. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411243312107 · Cited by 1,078
Kaufman, D. L., Clare-Salzler, M., Tian, J., Forsthuber, T., Ting, G. S. P., Robinson, P., Atkinson, M. A., Sercarz, E. E., Tobin, A. J., & Lehmann, P. V. (1993) · Nature · doi:10.1038/366069a0 · Cited by 1,070
Cited by
Salomon, B., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,081
Review: Environmental exposure to mercury and its toxicopathologic implications for public health
Tchounwou, P. B., Ayensu, W. K., Ninashvili, N., & Sutton, D. (2003) · Environmental Toxicology · doi:10.1002/tox.10116 · Cited by 1,298
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD
Delovitch, T. L., & Singh, B. (1997) · Immunity · doi:10.1016/s1074-7613(00)80392-1 · Cited by 676
Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy
Prabhakar, B. S., Bahn, R. S., & Smith, T. J. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0020 · Cited by 489
Metadata
- Authors
- André, I., Gonzalez, A., Wang, B., Katz, J., Benoist, C., & Mathis, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-03-19
- Volume
- 93
- Issue
- 6
- Pages
- 2260-2263
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2076905634
- Cited by
- 337
- References
- 52
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- green
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