The Fas Death Factor

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736 · see citing works

Social controls on cell survival and cell death

RAFF, M. C. (1992) · Nature · doi:10.1038/356397a0 · Cited by 2,634 · see citing works

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Suda, T., Takahashi, T., Golstein, P., & Nagata, S. (1993) · Cell · doi:10.1016/0092-8674(93)90326-l · Cited by 2,488 · see citing works

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,106 · see citing works

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909 · see citing works

Lethal effect of the anti-Fas antibody in mice

Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881 · see citing works

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814 · see citing works

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Kägi, D., Ledermann, B., Bürki, K., Seiler, P. J., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1994) · Nature · doi:10.1038/369031a0 · Cited by 1,758 · see citing works

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716 · see citing works

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

Andrews, B. S., Eisenberg, R. A., Theofilopoulos, A. N., Izui, S., Wilson, C. B., McConahey, P. J., Murphy, E. D., Roths, J. B., & Dixon, F. J. (1978) · The Journal of Experimental Medicine · doi:10.1084/jem.148.5.1198 · Cited by 1,600 · see citing works

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,527 · see citing works

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., & Golstein, P. (1994) · Science · doi:10.1126/science.7518614 · Cited by 1,513 · see citing works

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,442 · see citing works

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398 · see citing works

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Miura, M. (1993) · Cell · doi:10.1016/0092-8674(93)90486-a · Cited by 1,382 · see citing works

A novel domain within the 55 kd TNF receptor signals cell death

Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290 · see citing works

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

Cohen, P. L., & Eisenberg, R. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001331 · Cited by 1,169 · see citing works

Apoptosis And Programmed Cell Death In Immunity

Cohen, J., Duke, R. C., Fadok, V. A., & Sellins, K. S. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001411 · Cited by 1,112 · see citing works

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., & Mountz, J. D. (1994) · Science · doi:10.1126/science.7510905 · Cited by 1,108 · see citing works

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054 · see citing works

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

Lowin, B., Hahne, M., Mattmann, C., & Tschopp, J. (1994) · Nature · doi:10.1038/370650a0 · Cited by 1,052 · see citing works

Fas ligand mediates activation-induced cell death in human T lymphocytes.

Alderson, M. R., Tough, T. W., Davis-Smyth, T., Braddy, S., Falk, B. A., Schooley, K., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.71 · Cited by 933 · see citing works

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

Kolesnick, R. N. (1994) · Cell · doi:10.1016/0092-8674(94)90147-3 · Cited by 932 · see citing works

Fas and Fas ligand: lpr and gld mutations

Nagata, S., & Suda, T. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80069-7 · Cited by 900 · see citing works

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

Webb, S. R., Morris, C., & Sprent, J. (1990) · Cell · doi:10.1016/0092-8674(90)90420-j · Cited by 885 · see citing works

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845 · see citing works

Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.

Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., & Trauth, B. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50076-x · Cited by 834 · see citing works

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen

Watanabe‐Fukunaga, R., Brannan, C. I., Itoh, N., Yonehara, S., Copeland, N. G., Jenkins, N. A., & Nagata, S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.4.1274 · Cited by 815 · see citing works

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., & Ley, T. J. (1994) · Cell · doi:10.1016/0092-8674(94)90376-x · Cited by 815 · see citing works

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

Rouvier, É., Luciani, M. F., & Golstein, P. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.1.195 · Cited by 799 · see citing works

Checkpoints of dueling dimers foil death wishes

Oltvai, Z. N. (1994) · Cell · doi:10.1016/0092-8674(94)90188-0 · Cited by 795 · see citing works

Negative selection of lymphocytes

Nossal, G. J. V. (1994) · Cell · doi:10.1016/0092-8674(94)90331-x · Cited by 794 · see citing works

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714 · see citing works

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Milian, J. A., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90410-7 · Cited by 698 · see citing works

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

Singer, G. G., & Abbas, A. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90067-1 · Cited by 697 · see citing works

Peripheral Selection of the T Cell Repertoire

Rocha, B., & von Boehmer, H. (1991) · Science · doi:10.1126/science.1900951 · Cited by 656 · see citing works

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 639 · see citing works

Mechanism of Lymphocyte-Mediated Cytotoxicity

Henkart, P. A. (1985) · Annual Review of Immunology · doi:10.1146/annurev.immunol.3.1.31 · Cited by 602 · see citing works

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

Newmeyer, D. (1994) · Cell · doi:10.1016/0092-8674(94)90203-8 · Cited by 581 · see citing works

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

Cifone, M. G., Maria, R. D., Roncaioli, P., Rippo, M. R., Azuma, M., Lanier, L. L., Santoni, A., & Testi, R. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1547 · Cited by 573 · see citing works

Positive selection of lymphocytes

von Boehmer, H. (1994) · Cell · doi:10.1016/0092-8674(94)90330-1 · Cited by 558 · see citing works

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

Scollay, R. G., Butcher, E. C., & Weissman, I. L. (1980) · European Journal of Immunology · doi:10.1002/eji.1830100310 · Cited by 555 · see citing works

Programmed cell death and Bcl‐2 protection in the absence of a nucleus.

Jacobson, M. D., Burne, J. F., & RAFF, M. C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06459.x · Cited by 548 · see citing works

Patterns of cell death.

Walker, N. I., HARMON, B. V., Gobe, G. C., & Kerr, J. F. R. (1988) · PubMed · Cited by 527 · see citing works

Purification and characterization of the Fas-ligand that induces apoptosis.

Suda, T., & Nagata, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.873 · Cited by 516 · see citing works

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

Adachi, M., Watanabe‐Fukunaga, R., & Nagata, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1756 · Cited by 509 · see citing works

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood

Miyawaki, T., Uehara, T., Nibu, R., Tsuji, T., Yachie, A., Yonehara, S., & Taniguchi, N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.11.3753 · Cited by 494 · see citing works

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

Ando, K., Moriyama, T., Guidotti, L. G., Wirth, S., Schreiber, R. D., Schlicht, H. J., Huang, S. N., & Chisari, F. V. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.5.1541 · Cited by 449 · see citing works

Activation interferes with the APO-1 pathway in mature human T cells

Klas, C., Debatin, K., Jonker, R. R., & Krammer, P. H. (1993) · International Immunology · doi:10.1093/intimm/5.6.625 · Cited by 447 · see citing works

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

Jarvis, W. D., Kolesnick, R., Fornari, F. A., Traylor, R. S., Gewirtz, D. A., & Grant, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.73 · Cited by 447 · see citing works

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G., & Earnshaw, W. C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.1.7 · Cited by 445 · see citing works

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine.

Weinberg, J. B., Granger, D. L., Pisetsky, D. S., Seldin, M. F., Misukonis, M. A., Mason, S. N., Pippen, A. M., Ruiz, P., Wood, E. R., & Gilkeson, G. S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.651 · Cited by 435 · see citing works

Effect of bcl-2 on Fas antigen-mediated cell death.

Itoh, N., Tsujimoto, Y., & Nagata, S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.2.621 · Cited by 434 · see citing works

Human Fas ligand: gene structure, chromosomal location and species specificity

Takahashi, T., Tanaka, M., Inazawa, J., Abe, T., Suda, T., & Nagata, S. (1994) · International Immunology · doi:10.1093/intimm/6.10.1567 · Cited by 433 · see citing works

Cell nucleus and DNA fragmentation are not required for apoptosis.

Schulze‐Osthoff, K., Walczak, H., Dröge, W., & Krammer, P. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.1.15 · Cited by 429 · see citing works

Unraveling Function in the TNF Ligand and Receptor Families

Beutler, B., & Huffel, C. V. (1994) · Science · doi:10.1126/science.8171316 · Cited by 419 · see citing works

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

Podack, E. R., Young, J. D., & Cohn, Z. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8629 · Cited by 400 · see citing works

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

Russell, J. H., Rush, B., Weaver, C. T., & Wang, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4409 · Cited by 398 · see citing works

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

Izui, S., Kelley, V. E., Masuda, K., Yoshida, H., Roths, J. B., & Murphy, E. D. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.133.1.227 · Cited by 386 · see citing works

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

Stalder, T., Hahn, S., & Erb, P. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.3.1127 · Cited by 379 · see citing works

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

Owen‐Schaub, L. B., Yonehara, S., Crump, W. L., & Grimm, E. A. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90187-t · Cited by 372 · see citing works

A natural killer cell granule protein that induces DNA fragmentation and apoptosis.

Shi, L., Kraut, R. P., Aebersold, R. H., & Greenberg, A. H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.553 · Cited by 367 · see citing works

Diversity of Cytokine Synthesis and Function of Mouse CD4+ T Cells

Mosmann, T. R., Schumacher, J. H., Street, N. F., Budd, R. C., O’Garra, A., Fong, T. A. T., Bind, M. W., Moore, K. W., Sher, A., & Fiorentino, D. F. (1991) · Immunological Reviews · doi:10.1111/j.1600-065x.1991.tb00612.x · Cited by 362 · see citing works

Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C

Hiramatsu, N., Hayashi, N., Katayama, K., Mochizuki, K., Kawanishi, Y., Kasahara, A., Fusamoto, H., & Kamada, T. (1994) · Hepatology · doi:10.1002/hep.1840190606 · Cited by 355 · see citing works

Fas and Fas Ligand: A Death Factor and Its Receptor

Nagata, S. (1994) · Advances in immunology · doi:10.1016/s0065-2776(08)60672-0 · Cited by 348 · see citing works

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

Hu, H., O’Rourke, K. M., Boguski, M. S., & Dixit, V. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43772-6 · Cited by 341 · see citing works

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

Watson, M., Rao, J. K., Gilkeson, G. S., Ruiz, P., Eicher, E. M., Pisetsky, D. S., Matsuzawa, A., Rochelle, J. M., & Seldin, M. F. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1645 · Cited by 339 · see citing works

Kinetics of mature T-cell development in the thymus.

Egerton, M., Scollay, R. G., & Shortman, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.7.2579 · Cited by 333 · see citing works

The mouse fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster

Lynch, D. H., Watson, M. L., Alderson, M. R., Baum, P. R., Miller, R. E., Tough, T. W., Gibson, M., Davis-Smyth, T., Smiths, C. A., Hunter, K. W., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90106-6 · Cited by 331 · see citing works

Clonal expansion precedes anergy and death of Vβ8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo

MacDonald, H. R., Baschieri, S., & Lees, R. K. (1991) · European Journal of Immunology · doi:10.1002/eji.1830210827 · Cited by 320 · see citing works

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

Kabelitz, D., Pohl, T., & Pechhold, K. (1993) · Immunology Today · doi:10.1016/0167-5699(93)90231-9 · Cited by 311 · see citing works

Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death

Ramsdell, F., Seaman, M. S., Miller, R. E., Picha, K. S., Kennedy, M. K., & Lynch, D. H. (1994) · International Immunology · doi:10.1093/intimm/6.10.1545 · Cited by 311 · see citing works

Divergent signalling via APO‐1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.

Schulze‐Osthoff, K., Krammer, P., & Dröge, W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06780.x · Cited by 302 · see citing works

A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.

Roths, J. B., Murphy, E. D., & Eicher, E. M. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.159.1.1 · Cited by 301 · see citing works

A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease.

Sneller, M. C., Straus, S. E., Jaffe, E. S., Jaffe, J. S., Fleisher, T. A., Stetler‐Stevenson, M., & Strober, W. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115867 · Cited by 300 · see citing works

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

Ju, S., Cui, H., Panka, D. J., Ettinger, R., & Marshak‐Rothstein, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4185 · Cited by 293 · see citing works

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

Wu, J., Zhou, T., He, J. H., & Mountz, J. D. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.461 · Cited by 287 · see citing works

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

Kojima, H., Shinohara, N., Hanaoka, S., Shirota-Someya, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita∥, H., Okumura, K., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90066-3 · Cited by 286 · see citing works

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34.

Baum, P. R., Gayle, R. B., Ramsdell, F., Srinivasan, S., Sorensen, R. A., Watson, M., Seldin, M. F., Baker, E. G., Sutherland, G. R., & Clifford, K. N. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06715.x · Cited by 283 · see citing works

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

Hanabuchi, S., Koyanagi, M., Kawasaki, A., Shinohara, N., Matsuzawa, A., Nishimura, Y., Kobayashi, Y., Yonehara, S., Yagita∥, H., & Okumura, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4930 · Cited by 280 · see citing works

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens

Dhein, J., Daniel, P. T., Trauth, B. C., Oehm, A., Möller, P., & Krammer, P. H. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3166 · Cited by 278 · see citing works

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

Chu, J. L., Drappa, J., Parnassa, A. P., & Elkon, K. B. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.723 · Cited by 245 · see citing works

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

Shiver, J. W., Su, L., & Henkart, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90359-k · Cited by 235 · see citing works

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen

McCormack, J. E., Callahan, J. E., Kappler, J. W., & Marrack, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3785 · Cited by 234 · see citing works

Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor- alpha secretion

Oyaizu, N., McCloskey, T. W., Than, S., Hu, R., Kalyanaraman, V. S., & Pahwa, S. G. (1994) · Blood · doi:10.1182/blood.v84.8.2622.2622 · Cited by 207 · see citing works

Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody.

Ogasawara, J., Suda, T., & Nagata, S. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.485 · Cited by 199 · see citing works

Fas-Mediated Apoptosis in Primary Cultured Mouse Hepatocytes

Ni, R., Tomita, Y., Matsuda, K., Ichihara, A., Ishimura, K., Ogasawara, J., & Nagata, S. (1994) · Experimental Cell Research · doi:10.1006/excr.1994.1349 · Cited by 198 · see citing works

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

Wong, G. H., & Goeddel, D. V. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.4.1751 · Cited by 196 · see citing works

T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A

Anel, A., Buferne, M., Boyer, C., Schmitt‐Verhulst, A., & Golstein, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241032 · Cited by 196 · see citing works

Cytotoxic T lymphocyte mediated lysis without release of serine esterase

Ostergaard, H. L., Kane, K. P., Mescher, M. F., & Clark, W. R. (1987) · Nature · doi:10.1038/330071a0 · Cited by 191 · see citing works

TCR/CD3 coupling to Fas-based cytotoxicity.

Vignaux, F., Vivier, É., MALISSEN, B., Depraetere, V., Nagata, S., & Golstein, P. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.781 · Cited by 184 · see citing works

The molecular mechanism of lymphocyte-mediated tumor cell lysis

Podack, E. R. (1985) · Immunology Today · doi:10.1016/0167-5699(85)90164-1 · Cited by 180 · see citing works

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

Eischen, C. M., Dick, C. J., & Leibson, P. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.5.1947 · Cited by 179 · see citing works

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

Daniel, P. T., & Krammer, P. H. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.12.5624 · Cited by 176 · see citing works

Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes

Trenn, G., Takayama, H., & Sitkovsky, M. V. (1987) · Nature · doi:10.1038/330072a0 · Cited by 171 · see citing works

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children [letter]

Debatin, K., Fahrig-Faissner, A., Enenkel-Stoodt, S., Kreuz, W., Benner, A., & Krammer, P. (1994) · Blood · doi:10.1182/blood.v83.10.3101a.3101a · Cited by 169 · see citing works

Structure of the human APO‐1 gene

Behrmann, I., Walczak, H., & Krammer, P. H. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241221 · Cited by 165 · see citing works

Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.

Rathmell, J. C., & Goodnow, C. C. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2831 · Cited by 155 · see citing works

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

Vignaux, F., & Golstein, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240421 · Cited by 151 · see citing works

Selection of the T cell receptor repertoire in Lpr mice.

Herron, L. R., Eisenberg, R. A., Roper, E., Kakkanaiah, V. N., Cohen, P. L., & Kotzin, B. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.7.3450 · Cited by 149 · see citing works

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

Russell, J. H., & Wang, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230951 · Cited by 147 · see citing works

Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.

Clement, M., & Stamenkovic, I. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.2.557 · Cited by 142 · see citing works

Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

Debatin, K., Krammer, P. H., Goldman, C. K., Bamford, R. N., & Waldmann, T. A. (1990) · The Lancet · doi:10.1016/0140-6736(90)90735-n · Cited by 140 · see citing works

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

Wu, J., Zhou, T., Zhang, J., He, J., Gause, W. C., & Mountz, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2344 · Cited by 140 · see citing works

gld/gld mice are unable to express a functional ligand for Fas

Ramsdell, F., Seaman, M. S., Miller, R. E., Tough, T. W., Alderson, M. R., & Lynch, D. H. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240422 · Cited by 139 · see citing works

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

Sidman, C. L., Marshall, J. D., & von Boehmer, H. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220231 · Cited by 130 · see citing works

Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules.

Allen, R. D., Marshall, J. D., Roths, J. B., & Sidman, C. L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.5.1367 · Cited by 129 · see citing works

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.

Matsuzawa, A., Moriyama, T., Kaneko, T., Tanaka, M., Kimura, M., Ikeda, H., & Katagiri, T. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.2.519 · Cited by 128 · see citing works

Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.

Chu, J. L., Ramos, P. S., Rosendorff, A., Nikolić‐Žugić, J., Lacy, E., Matsuzawa, A., & Elkon, K. B. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.393 · Cited by 121 · see citing works

Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication.

Kobayashi, N., Hamamoto, Y., Yamamoto, N., Ishii, A., Yonehara, M., & Yonehara, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9620 · Cited by 118 · see citing works

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

Watanabe, D., Suda, T., Hashimoto, H., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06970.x · Cited by 115 · see citing works

Fatal interactions: fas-induced apoptosis of mature T cells

Crispe, I. N. (1994) · Immunity · doi:10.1016/1074-7613(94)90064-7 · Cited by 110 · see citing works

Association of lpr gene with graft-vs.-host disease-like syndrome.

Theofilopoulos, A. N., BALDERAS, R. S., Gozes, Y., Aguado, M. T., Hang, L. M., Morrow, P. R., & Dixon, F. J. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.1.1 · Cited by 108 · see citing works

No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis

Hug, H., Enari, M., & Nagata, S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00852-3 · Cited by 107 · see citing works

Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas

Moller, P., Henne, C., Leithäuser, F., Eichelmann, A., Schmidt, A., Brüderlein, S., Dhein, J., & Krammer, P. (1993) · Blood · doi:10.1182/blood.v81.8.2067.2067 · Cited by 98 · see citing works

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

Falk, M., Trauth, B. C., Debatin, K., Klas, C., Gregory, C., Rickinson, A. B., Calender, A., Lenoir, G., Ellwart, J., & Krammer, P. (1992) · Blood · doi:10.1182/blood.v79.12.3300.bloodjournal79123300 · Cited by 96 · see citing works

CD4 engagement induces Fas antigen‐dependent apoptosis of T cells in vivo

Wang, Z., Dudhane, A., Orlikowsky, T. W., Clarke, K., Li, X., Darżynkiewicz, Z., & Hoffmann, M. K. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240714 · Cited by 93 · see citing works

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

Nakajima, H., Golstein, P., & Henkart, P. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.5.1905 · Cited by 90 · see citing works

Assignment of the human fas antigen gene (FAS) to 10q24.1

Inazawa, J., Itoh, N., Abe, T., & Nagata, S. (1992) · Genomics · doi:10.1016/s0888-7543(05)80200-9 · Cited by 86 · see citing works

The role of the Fas lytic pathway in a perforin-less CTL hybridoma.

Walsh, C. M., Glass, A. A., Chiu, V. K., & Clark, W. R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2506 · Cited by 84 · see citing works

Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice.

Lowrance, J. H., O’Sullivan, F. X., Caver, T. E., Waegell, W., & Gresham, H. D. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1693 · Cited by 83 · see citing works

A linkage map of mouse Chromosome 1 using an interspecific cross segregating for the gld autoimmunity mutation

Watson, M. L., D’Eustachio, P., Mock, B. A., Steinberg, A. D., Morse, H. C., Oakey, R. J., Howard, T. A., Rochelle, J. M., & Seldin, M. F. (1992) · Mammalian Genome · doi:10.1007/bf00302874 · Cited by 83 · see citing works

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

Gillette‐Ferguson, I., & Sidman, C. L. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240526 · Cited by 80 · see citing works

Transcriptional Repression and Differential Splicing of Fas m-RNA by Early Transposon (ETn) Insertion in Autoimmune LPR Mice

Kobayashi, S., Hirano, T., Kakinuma, M., & Uede, T. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1262 · Cited by 77 · see citing works

Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).

Young, J. D., Damiano, A., Dinome, M. A., Leong, L. G., & Cohn, Z. A. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.5.1371 · Cited by 71 · see citing works

T-lymphocyte-mediated cytolysis as an excitatory process of the target

Tirosh, R., & Berke, G. (1985) · Cellular Immunology · doi:10.1016/0008-8749(85)90300-4 · Cited by 70 · see citing works

A molecular genetic linkage map of mouse chromosome 19, including thelpr, Ly-44, andTdt genes

Watanabe, T., Sakai, Y., Miyawaki, S., Shimizu, A., Koiwai, O., & Ohno, K. (1991) · Biochemical Genetics · doi:10.1007/bf00554140 · Cited by 66 · see citing works

APOPTOSIS AND THE IMMUNE RESPONSE

Gregory, C. D. (1996) · Shock · doi:10.1097/00024382-199602000-00013 · Cited by 65 · see citing works

A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes.

Young, J. D., Clark, W. R., Liu, C. C., & Cohn, Z. A. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.6.1894 · Cited by 62 · see citing works

Early and late B-cell development in the mouse

Rajewsky, K. (1992) · Current Opinion in Immunology · doi:10.1016/0952-7915(92)90008-3 · Cited by 53 · see citing works

Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo.

Webb, S. R., Hutchinson, J., Hayden, K., & Sprent, J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.586 · Cited by 52 · see citing works

The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19

Lichter, P., Walczak, H., Weitz, S., Behrmann, I., & Krammer, P. H. (1992) · Genomics · doi:10.1016/s0888-7543(05)80302-7 · Cited by 48 · see citing works

The onset of Fas expression parallels the acquisition of CD8 and CD4 in fetal and adult αβ thymocytes

Andjelić, S., Drappa, J., Lacy, E., Elkon, K. B., & Nikoiić-Žugić, J. (1994) · International Immunology · doi:10.1093/intimm/6.1.73 · Cited by 42 · see citing works

In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR- beta low cells.

Laouar, Y., & Ezine, S. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.9.3948 · Cited by 35 · see citing works

Limited specific T-cell mediated cytolysis in the absence of extracellular Ca2+.

Maclennan, I. C. M., Gotch, F., & Golstein, P. (1980) · PubMed · Cited by 35 · see citing works

The expansion of a CD4+ T cell population bearing a distinctive β chain in MRL lpr/lpr mice suggests a role for the fas protein in peripheral T cell selection

Musette, P., Pannetier, C., Gachelin, G., & Kourilsky, P. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241128 · Cited by 34 · see citing works

Establishment of apoptosis‐inducing monoclonal antibody 2D1 and 2D1‐resistant variants of human T cell lines

Takahashi, S., Sato, N., Takayama, S., Ichimiya, S., Satoh, M., Hyakumachi, N., & Kikuchi, K. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230831 · Cited by 30 · see citing works

Calcium is essential for both the membrane binding and lytic activity of pore-forming protein (perforin) from cytotoxic T-lymphocyte

Shoichi, I., Kiyoshi, M., Hirotaka, K., Tsukahara, T., Arahata, K., & Sugita, H. (1990) · Molecular Immunology · doi:10.1016/0161-5890(90)90090-m · Cited by 27 · see citing works

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS

Hiromatsu, K., Aoki, Y., Makino, M., Matsumoto, Y., Mizuochi, T., Gotoh, Y., Nomoto, K., Ogasawara, J., Nagata, S., & Yoshikai, Y. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241028 · Cited by 27 · see citing works

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works

Apoptosis by Death Factor

Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,908 · see citing works

The TNF and TNF Receptor Superfamilies

Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,181 · see citing works

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046 · see citing works

Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793 · see citing works

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749 · see citing works

Targeting apoptosis in cancer therapy

Carneiro, B. A., & El‐Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,594 · see citing works

Inhibition of death receptor signals by cellular FLIP

Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works

Mechanisms and Genes of Cellular Suicide

Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,465 · see citing works

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Boldin, M. P., Goncharov, T. M., Goltseve, Y. V., & Wallach, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81265-9 · Cited by 2,292 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918 · see citing works

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777 · see citing works

Immunological memory and protective immunity: understanding their relation

Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · see citing works

The Receptor for the Cytotoxic Ligand TRAIL

Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755 · see citing works

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., & Sakaguchi, S. (2002) · Nature Immunology · doi:10.1038/ni759 · Cited by 1,729 · see citing works

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80011-4 · Cited by 1,638 · see citing works

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubat, T., Yagita, H., & Honjo, T. (1996) · International Immunology · doi:10.1093/intimm/8.5.765 · Cited by 1,589 · see citing works

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

Pan, G., Ni, J., Wei, Y.-F., Yu, G.-L., Gentz, R., & Dixit, V. M. (1997) · Science · doi:10.1126/science.277.5327.815 · Cited by 1,486 · see citing works

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

Fisher, G. H., Rosenberg, F. J., Straus, S. E., Dale, J. K., Middelton, L. A., Lin, A. Y., Strober, W., Lenardo, M. J., & Puck, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90013-6 · Cited by 1,454 · see citing works

Apoptosis in Myocytes in End-Stage Heart Failure

Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430 · see citing works

Interleukin-18 Regulates Both Th1 and Th2 Responses

Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,310 · see citing works

Life, death, and the pursuit of apoptosis.Preprint

White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,300 · see citing works

Functional significance of the perforin/granzyme cell death pathway

Trapani, J. A., & Smyth, M. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri911 · Cited by 1,289 · see citing works

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

Hahne, M., Rimoldi, D., Schröter, M., Romero, P. J., Schreier, M. H., French, L. E., Schneider, P., Bornand, T., Fontana, A., Liénard, D., et al. (1996) · Science · doi:10.1126/science.274.5291.1363 · Cited by 1,236 · see citing works

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

Varfolomeev, E., Schuchmann, M., Luria, V., Chiannilkulchai, N., Beckmann, J., Mett, I., Rebrikov, D., Brodianski, V. M., Kemper, O., Kollet, O., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80609-3 · Cited by 1,332 · see citing works

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182 · see citing works

Natural Killer Cells: Development, Maturation, and Clinical Utilization

Abel, A. M., Yang, C., Thakar, M. S., & Malarkannan, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01869 · Cited by 1,150 · see citing works

A role for CD95 ligand in preventing graft rejection

Bellgrau, D., Gold, D. P., Selawry, H. P., Moore, J. K., Franzusoff, A., & Duke, R. C. (1995) · Nature · doi:10.1038/377630a0 · Cited by 1,147 · see citing works

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

Lam, K., Kühn, R., & Rajewsky, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80373-6 · Cited by 1,101 · see citing works

Ovarian Surface Epithelium: Biology, Endocrinology, and Pathology

Auersperg, N., Wong, A. S. T., Choi, K., Kang, S. K., & Leung, P. C. K. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0422 · Cited by 1,040 · see citing works

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

Kulik, G., Klippel, A., & Weber, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1595 · Cited by 1,033 · see citing works

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

Chambers, C. A., Kuhns, M. S., Egen, J. G., & Allison, J. P. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.565 · Cited by 1,000 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 982 · see citing works

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

Enari, M., Talanian, R. V., Wrong, W. W., & Nagata, S. (1996) · Nature · doi:10.1038/380723a0 · Cited by 958 · see citing works

BID: a novel BH3 domain-only death agonist.Preprint

Wang, K., Yin, X., Chao, D. T., Milliman, C. L., & Korsmeyer, S. J. (1996) · Genes & Development · doi:10.1101/gad.10.22.2859 · Cited by 941 · see citing works

Caspase activation: The induced-proximity model

Salvesen, G. S., & Dixit, V. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.10964 · Cited by 932 · see citing works

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

Lenardo, M. J., Chan, F. K.-M., Hornung, F., McFarland, H. F., Siegel, R. M., Wang, J., & Zheng, L. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.221 · Cited by 931 · see citing works

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

Krummel, M. F., & Allison, J. P. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2533 · Cited by 923 · see citing works

Cytotoxic T lymphocytes: all roads lead to death

Barry, M., & Bleackley, R. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri819 · Cited by 915 · see citing works

Apoptotic DNA Fragmentation

Nagata, S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4834 · Cited by 906 · see citing works

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

Ha, H. C., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13978 · Cited by 904 · see citing works

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

O’Connell, J., O’Sullivan, G. C., Collins, J. K., & Shanahan, F. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.3.1075 · Cited by 873 · see citing works

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., & Tan, T.-H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31929 · Cited by 867 · see citing works

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosisPreprint

Lin, Y., Devin, A., Rodriguez, Y., & Liu, Z.-G. (1999) · Genes & Development · doi:10.1101/gad.13.19.2514 · Cited by 835 · see citing works

The machinery of programmed cell death

Zimmermann, K. C., Bonzon, C., & Green, D. R. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00159-0 · Cited by 829 · see citing works

Metalloproteinase-mediated release of human Fas ligand.

Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., Yoshino, K., Okumura, K., & Yagita∥, H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1777 · Cited by 816 · see citing works

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

Degli‐Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., & Goodwin, R. G. (1997) · Immunity · doi:10.1016/s1074-7613(00)80399-4 · Cited by 815 · see citing works

Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

Rowland, J. W., Hawryluk, G. W. J., Kwon, B. K., & Fehlings, M. G. (2008) · Neurosurgical FOCUS · doi:10.3171/foc.2008.25.11.e2 · Cited by 815 · see citing works

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

Schneider, P., Holler, N., Bodmer, J.-L., Hahne, M., Frei, K., Fontana, A., & Tschopp, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.8.1205 · Cited by 804 · see citing works

Two tumour necrosis factor receptors: structure and function

Vandenabeele, P., Declercq, W., Beyaert, R., & Fiers, W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89088-1 · Cited by 799 · see citing works

Brain ischemia and reperfusion: molecular mechanisms of neuronal injury

White, B. C., Sullivan, J. M., DeGracia, D. J., O’Neil, B. J., Neumar, R. W., Grossman, L. I., Rafols, J. A., & Krause, G. S. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00386-5 · Cited by 796 · see citing works

Flow cytometry of apoptotic cell death

Vermes, I., Haanen, C., & Reutelingsperger, C. P. M. (2000) · Journal of Immunological Methods · doi:10.1016/s0022-1759(00)00233-7 · Cited by 795 · see citing works

Expression of galectin-3 modulates T-cell growth and apoptosis.

Yang, R., Hsu, D. K., & Liu, F. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6737 · Cited by 790 · see citing works

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1

Greijer, A. E., & van der Wall, E. (2004) · Journal of Clinical Pathology · doi:10.1136/jcp.2003.015032 · Cited by 781 · see citing works

Fas Ligand-Induced Apoptosis

Nagata, S. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.29 · Cited by 772 · see citing works

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

Smedt, T. D., Pajak, B., Muraille, É., Lespagnard, L., Heinen, E., BAETSELIER, P. D., Urbain, J., Léo, O., & Moser, M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1413 · Cited by 755 · see citing works

Reactive oxygen species and programmed cell death

Jacobson, M. D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20008-8 · Cited by 753 · see citing works

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

Hallek, M. J., Bergsagel, P. L., & Anderson, K. C. (1998) · Blood · doi:10.1182/blood.v91.1.3 · Cited by 747 · see citing works

Involvement of an ICE-like protease in Fas-mediated apoptosis

Enari, M., Hug, H., & Nagata, S. (1995) · Nature · doi:10.1038/375078a0 · Cited by 732 · see citing works

Defying death after DNA damage

Rich, T., Allen, R. L., & Wyllie, A. H. (2000) · Nature · doi:10.1038/35037717 · Cited by 724 · see citing works

Necrosis: a specific form of programmed cell death?

Proskuryakov, S., Konoplyannikov, A. G., & Gabai, V. L. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00027-7 · Cited by 721 · see citing works

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

Zhang, J., Cado, D., Chen, A., Kabra, N., & Winoto, A. (1998) · Nature · doi:10.1038/32681 · Cited by 792 · see citing works

TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis

Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu, Y., Scott, H. S., Hession, C. A., Garcia, I., & Browning, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32401 · Cited by 690 · see citing works

Downregulation of Fas ligand by shedding

Tanaka, M., Itai, T., Adachi, M., & Nagata, S. (1998) · Nature Medicine · doi:10.1038/nm0198-031 · Cited by 666 · see citing works

Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury

Ziebell, J. M., & Morganti-Kossmann, M. C. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2009.10.016 · Cited by 665 · see citing works

Intracellular Regulation of TRAIL-Induced Apoptosis in Human Melanoma Cells

Griffith, T. S., Chin, W. A., Jackson, G. C., Lynch, D. H., & Kubin, M. Z. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.2833 · Cited by 663 · see citing works

Fas ligand in human serum

Tanaka, M., Suda, T., Haze, K., Nakamura, N., Sato, K., Kimura, F., Motoyoshi, K., Mizuki, M., Tagawa, S., Ohga, S., et al. (1996) · Nature Medicine · doi:10.1038/nm0396-317 · Cited by 660 · see citing works

Apoptosis: Molecular Regulation of Cell Death

Hale, A. J., Smith, C. A., Sutherland, L. C., Stoneman, V. E. A., Longthorne, V. L., Culhane, A. C., & Williams, G. T. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00001.x · Cited by 659 · see citing works

Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu

NAKANISHI, K., YOSHIMOTO, T., Tsutsui, H., & Okamura, H. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00015-0 · Cited by 658 · see citing works

On the origin, evolution, and nature of programmed cell death: a timeline of four billion years

Ameisen, J. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400950 · Cited by 656 · see citing works

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

Chinnaiyan, A. M., O’Rourke, K. M., Yu, G.-L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., & Dixit, V. M. (1996) · Science · doi:10.1126/science.274.5289.990 · Cited by 653 · see citing works

Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

Zhou, Y., Wang, Y., Wang, J., Stetler, R. A., & Yang, Q. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.003 · Cited by 650 · see citing works

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

Kim, J. M., & Chen, D. S. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw217 · Cited by 648 · see citing works

A License to Kill

Fraser, A. G., & Evan, G. I. (1996) · Cell · doi:10.1016/s0092-8674(00)81005-3 · Cited by 632 · see citing works

Programmed cell death and Bcl-2 protection in very low oxygen

Jacobson, M. D., & RAFF, M. C. (1995) · Nature · doi:10.1038/374814a0 · Cited by 625 · see citing works

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems

Walczak, H., & Krammer, P. H. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4840 · Cited by 624 · see citing works

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

Süss, G., & Shortman, K. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1789 · Cited by 622 · see citing works

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

Susín, S. A., Zamzami, N., Castedo, M., Daugas, É., Wang, H., Geley, S., Fassy, F., Reed, J. C., & Kroemer, G. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.1.25 · Cited by 616 · see citing works

Small Stress Proteins as Novel Regulators of Apoptosis

Mehlen, P., Schulze‐Osthoff, K., & Arrigo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16510 · Cited by 604 · see citing works

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

Kägi, D., Ledermann, B., Bürki, K., Zinkernagel, R. M., & Hengartner, H. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.207 · Cited by 582 · see citing works

The Bax/Bcl-2 Ratio Determines the Susceptibility of Human Melanoma Cells to CD95/Fas-Mediated Apoptosis

Raisova, M., Hossini, A. M., Eberle, J., Riebeling, C., Orfanos, C. E., Geilen, C. C., Wieder, T., Sturm, I., & Daniel, P. T. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01409.x · Cited by 572 · see citing works

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

Giordano, C. S. D. S., Stassi, G., Maria, R. D., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R., & Galluzzo, A. (1997) · Science · doi:10.1126/science.275.5302.960 · Cited by 572 · see citing works

Natural Killer (NK) Cell–mediated Cytotoxicity: Differential Use of TRAIL and Fas Ligand by Immature and Mature Primary Human NK Cells

Zamai, L., Ahmad, M., Bennett, I. M., Azzoni, L., Alnemri, E. S., & PERUSSIA, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2375 · Cited by 564 · see citing works

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

Liles, W. C., Kiener, P. A., Ledbetter, J. A., Aruffo, A. A., & Klebanoff, S. J. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.429 · Cited by 553 · see citing works

A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis

Bortner, C. D., Hughes, F. M., & Cidlowski, J. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32436 · Cited by 549 · see citing works

The Fas System Is a Key Regulator of Germ Cell Apoptosis in the Testis

Lee, J., Richburg, J. H., Younkin, S. C., & Boekelheide, K. (1997) · Endocrinology · doi:10.1210/en.138.5.2081 · Cited by 536 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

Receptor‐mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD)

Okada, Y., Maeno, E., Shimizu, T., Dezaki, K., Wang, J., & Morishima, S. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0003g.x · Cited by 527 · see citing works

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation.

Rodrigues, C. M. P., Fan, G., Ma, X., Kren, B. T., & Steer, C. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1325 · Cited by 515 · see citing works

Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation

Ishihara, N., Matsuo, H., Murakoshi, H., Laoag‐Fernandez, J. B., Samoto, T., & Maruo, T. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.119176 · Cited by 509 · see citing works

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

Kumar, A., Commane, M., Flickinger, T. W., Horvath, C. M., & Stark, G. R. (1997) · Science · doi:10.1126/science.278.5343.1630 · Cited by 508 · see citing works

To Die or Not to Die

Hetts, S. W. (1998) · JAMA · doi:10.1001/jama.279.4.300 · Cited by 506 · see citing works

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

Durgeau, A., Virk, Y., Corgnac, S., & Mami‐Chouaib, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00014 · Cited by 495 · see citing works

The Role of Fas in Autoimmune Diabetes

Chervonsky, A. V., Wang, Y., Wong, F. S., Visintin, I., Flavell, R. A., Janeway, C. A., & Matis, L. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80178-6 · Cited by 489 · see citing works

SELECTION OF THE T CELL REPERTOIRE

Sebzda, E., Mariathasan, S., Ohteki, T., Jones, R. G., Bachmann, M. F., & Ohashi, P. S. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.829 · Cited by 489 · see citing works

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

Drappa, J., Vaishnaw, A. K., Sullivan, K. E., Chu, J., & Elkon, K. B. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611283352204 · Cited by 473 · see citing works

Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.

Wu, J., Wilson, J., He, J., Xiang, L., Schur, P. H., & Mountz, J. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118892 · Cited by 470 · see citing works

Fas ligand：Can it ever be tamed？

Rcduke, & Khance (2002) · Cell Research

Molecular and Cellular Mechanisms RegulatingTand B Cell Apoptosis through Fas/FasL Interaction

Ju, S., Matsui, K., & Özdemirli, M. (1999) · International Reviews of Immunology · doi:10.3109/08830189909088495 · Cited by 59 · see citing works

A death factor--the other side of the coin.

Nagata, S. (1996) · PubMed · Cited by 15 · see citing works

Apoptosis Mediated by the Fas System

Nagata, S. (1996) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-79850-4_6 · Cited by 68 · see citing works

Fas‐induced apoptosis, and diseases caused by its abnormality

Nagata, S. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.d01-214.x · Cited by 57 · see citing works