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The response regulator SprE controls the stability of RpoS.
Open accessAbstract
In Escherichia coli, the sigma factor, RpoS, is a central regulator in stationary-phase cells. We have identified a gene, sprE (stationary-phase regulator), as essential for the negative regulation of rpoS expression. SprE negatively regulates the rpoS gene product at the level of protein stability, perhaps in response to nutrient availability. The ability of SprE to destabilize RpoS is dependent on the ClpX/ClpP protease. Based on homology, SprE is a member of the response regulator family of proteins. SprE is the first response regulator identified that is implicated in the control of protein stability. Moreover, SprE is the first reported protein that appears to regulate rpoS in response to a specific environmental parameter.
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Citations
Cited by
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00797.x · Cited by 2,537
Hengge-Aronis, R. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.373-395.2002 · Cited by 936
The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein
Zhang, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.20.6061 · Cited by 784
PROTEASES AND THEIR TARGETS IN ESCHERICHIA COLI
Gottesman, S. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.465 · Cited by 717
Functional Modulation of Escherichia Coli RNA Polymerase
Ishihama, A. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.499 · Cited by 599
Metadata
- Authors
- Pratt, L. A., & Silhavy, T. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-03-19
- Volume
- 93
- Issue
- 6
- Pages
- 2488-2492
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2082494697
- Cited by
- 242
- References
- 0
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Pratt, L. A., & Silhavy, T. J. (1996). The response regulator SprE controls the stability of RpoS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.6.2488
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