The DOI matches its Crossref record.
Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture.
Open accessAbstract
Mutations in the endothelin 3 (EDN3) gene severely affect the development of neural crest-derived melanocytes. In this paper, we report the action of EDN3 on neural crest cells in vitro. The presence of EDN3 leads to a large increase in the number of cells, the majority of which eventually differentiate into melanocytes that aggregate to form a reproducible pigmentation pattern. Quantitative analysis of the effect of different culture conditions revealed that EDN3 initially promotes neural crest cell proliferation. This phase of expansion, which can be prolonged for a few weeks if the cells are replaced regularly, is followed by both a decrease in cell proliferation and the onset of melanocytic differentiation. Therefore, EDN3 is a potent mitogen for early neural crest cell precursors that can give rise to melanocytes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Opdecamp, K., Nakayama, A., Nguyen, M.-T. T., Hodgkinson, C. A., Pavan, W. J., & Arnheiter, H. (1997) · Development · doi:10.1242/dev.124.12.2377 · Cited by 299
Parichy, D. M., Mellgren, E. M., Rawls, J. F., Lopes, S. S., Kelsh, R. N., & Johnson, S. L. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9899 · Cited by 230
Costa-Silva, B., da Costa, M. C., Melo, F. R., Neves, C. M., Alvarez-Silva, M., Calloni, G. W., & Trentin, A. G. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.01.015 · Cited by 32
Metadata
- Authors
- Lahav, R., Ziller, C., Dupin, E., & Le Douarin, N. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-04-30
- Volume
- 93
- Issue
- 9
- Pages
- 3892-3897
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038935117
- Cited by
- 206
- References
- 0
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. https://app.cochat.ai/papers/10.1073/pnas.93.9.3892
- The paper
- Lahav, R., Ziller, C., Dupin, E., & Le Douarin, N. M. (1996). Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.9.3892
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
