The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.
Open accessAbstract
Clinically important mutant p53 proteins may be tumorigenic through a dominant-negative mechanism or due to a gain-of-function. Examples for both hypotheses have been described; however, it remains unclear to what extent they apply to TP53 mutations in general. Here it is shown that the mutational spectrum of dominant-negative p53 mutants selected in a novel yeast assay correlates tightly with p53 mutations in cancer. Two classes of dominant-negative mutations are described; the more dominant one affects codons that are essential for the stabilization of the DNA-binding surface of the p53 core domain and for the direct interaction of p53 with its DNA binding sites. These results predict that the vast majority of TP53 mutations leading to cancer do so in a dominant-negative fashion.
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Citations
Cites
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985
Cited by
TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199
Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation · doi:10.1002/humu.20495 · Cited by 1,598
“The first systematic study was performed in yeast, and measured the ability of 35 mutants to inhibit the TA of wildtype p53 on its consensus response-element [Brachmann et al., 1996].”
BackgroundTP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes
Petitjean, A., Achatz, M. I. W., Borresen-Dale, A. L., Hainaut, P., & Olivier, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210302 · Cited by 884
Tsoporis, J. N., Izhar, S., Leong-Poi, H., Desjardins, J.-F., Huttunen, H. J., & Parker, T. G. (2010) · Circulation Research · doi:10.1161/circresaha.109.195834 · Cited by 118
Metadata
- Authors
- Brachmann, R. K., Vidal, M., & Boeke, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1996-04-30
- Volume
- 93
- Issue
- 9
- Pages
- 4091-4095
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2151037269
- Cited by
- 158
- References
- 3
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Dominant-negative p53 mutations selected in yeast hit cancer hot spots. https://app.cochat.ai/papers/10.1073/pnas.93.9.4091
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- Brachmann, R. K., Vidal, M., & Boeke, J. D. (1996). Dominant-negative p53 mutations selected in yeast hit cancer hot spots. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.93.9.4091
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