TP53 mutations in human cancers: Functional selection and impact on cancer prognosis and outcomes
Abstract
A large amount of data is available on the functional impact of missense mutations in TP53 and on mutation patterns in many different cancers. New data on mutant p53 protein function, cancer phenotype and prognosis have recently been integrated in the International Agency for Research on Cancer TP53 database (http://www-p53.iarc.fr/). Based on these data, we summarize here current knowledge on the respective roles of mutagenesis and biological selection of mutations with specific functional characteristic in shaping the patterns and phenotypes of mutations observed in human cancers. The main conclusion is that intrinsic mutagenicity rates, loss of transactivation activities, and to a lesser extent, dominant-negative activities are the main driving forces that determine TP53 mutation patterns and influence tumor phenotype. In contrast, current experimental data on the acquisition of oncogenic activities (gain of function) by p53 mutants are too scarce and heterogenous to assess whether this property has an impact on tumor development and outcome. In the case of inherited TP53 mutations causing Li-Fraumeni and related syndromes, the age at onset of some tumor types is in direct relation with the degree of loss of transactivation capacity of missense mutations. Finally, studies on large case series demonstrate that TP53 mutations are independent markers of bad prognosis in breast and several other cancers, and that the exact type and position of the mutation influences disease outcome. Further studies are needed to determine how TP53 haplotypes or loss of alleles interact with mutations to modulate their impact on cancer development and prognosis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The mutational status of TP53 and its pathway elements ARF-MDM2/4 has not been correlated with survival in glioblastoma, despite the high mutation frequency.
“Although mut-p53 has been correlated to poorer prognosis in breast and other cancers [32], the mutational status of TP53 and its various pathway elements (ARF-MDM2/4) has not been correlated with survival in GBM, despite the high mutation frequency [27,32,33,34].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [32]
MDM2 amplifications have not been shown to correlate with glioblastoma survival and/or prognosis.
“MDM2 amplifications have not been shown to correlate with GBM survival and/or prognosis [27,32,33,34].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [32]
CDKN2A/ARF loss has not been shown to correlate with glioblastoma prognosis and/or survival.
“CDKN2A/ARF loss has not been shown to correlate with GBM prognosis and/or survival [27,32,33,34].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [32]
Cites
Sørlie, T., Perou, C., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M., van de Rijn, M., Jeffrey, S., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.191367098 · Cited by 11,695 · see citing works
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018 · see citing works
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693 · see citing works
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · see citing works
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679 · see citing works
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765 · see citing works
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,062 · see citing works
Somatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681 · see citing works
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · see citing works
Crypt stem cells as the cells-of-origin of intestinal cancer
Barker, N., Ridgway, R. A., van Es, J. H., van de Wetering, M., Begthel, H., van den Born, M., Danenberg, E., Clarke, A. R., Sansom, O. J., & Clevers, H. C. (2008) · Nature · doi:10.1038/nature07602 · Cited by 2,159 · see citing works
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921 · see citing works
Denissenko, M. F., Pao, A., Tang, M.-S., & Pfeifer, G. P. (1996) · Science · doi:10.1126/science.274.5286.430 · Cited by 1,650 · see citing works
Petitjean, A., Mathe, E., Kato, S., Ishioka, C., Tavtigian, S. V., Hainaut, P., & Olivier, M. (2007) · Human Mutation · doi:10.1002/humu.20495 · Cited by 1,598 · see citing works
Self-citationMutational hot spot in the p53 gene in human hepatocellular carcinomas
Hsu, I., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., & Harris, C. C. (1991) · Nature · doi:10.1038/350427a0 · Cited by 1,533 · see citing works
Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
Paillerets, B. B., Kew, M. C., Wands, J. R., & Öztürk, M. (1991) · Nature · doi:10.1038/350429a0 · Cited by 1,433 · see citing works
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308 · see citing works
A cancer family syndrome in twenty-four kindreds.
Li, F. P., Fraumeni, J. F., Mulvihill, J. J., Blattner, W. A., Dreyfus, M., Tucker, M., & Miller, R. (1988) · PubMed · Cited by 1,293 · see citing works
Miller, L. D., Smeds, J., George, J., Vega, V. B., Vergara, L. A., Ploner, A., Yudi Pawitan, Y., Hall, P. N., Klaar, S., Liu, E. T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506230102 · Cited by 1,269 · see citing works
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
Dumont, P., Leu, J. I.-J., Pietra, A. D., George, D. L., & Murphy, M. E. (2003) · Nature Genetics · doi:10.1038/ng1093 · Cited by 1,269 · see citing works
Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.022 · Cited by 1,265 · see citing works
The IARC TP53 database: new online mutation analysis and recommendations to users
Olivier, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C., & Hainaut, P. (2002) · Human Mutation · doi:10.1002/humu.10081 · Cited by 1,248 · see citing works
Self-citationOda, K., Arakawa, H., Tanaka, T., Matsuda, K., Tanikawa, C., Mori, T., Nishimori, H., Tamai, K., Tokino, T., Nakamura, Y., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00073-8 · Cited by 1,162 · see citing works
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
Pfeifer, G. P., Denissenko, M. F., Olivier, M., Tretyakova, N. Y., Hecht, S. S., & Hainaut, P. L. (2002) · Oncogene · doi:10.1038/sj.onc.1205803 · Cited by 1,114 · see citing works
Self-citationGain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069 · see citing works
p53 and Human Cancer: The First Ten Thousand Mutations
Hainaut, P. L., & Hollstein, M. C. (1999) · Advances in cancer research · doi:10.1016/s0065-230x(08)60785-x · Cited by 980 · see citing works
Self-citationRole of a p53 polymorphism in the development of human papilloma-virus-associated cancer
Storey, A., Thomas, M., Kalita, A., Harwood, C. A., Gardiol, D., Mantovani, F., Breuer, J., Leigh, I. M., Matlashewski, G., & Banks, L. (1998) · Nature · doi:10.1038/30400 · Cited by 971 · see citing works
Kato, S., Han, S., Liu, W., Otsuka, K., Shibata, H., Kanamaru, R., & Ishioka, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1431692100 · Cited by 877 · see citing works
Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors
Issaeva, N., Bozko, P. M., Enge, M., Protopopova, M., Verhoef, L. G. G. C., Masucci, M. G., Pramanik, A., & Selivanova, G. (2004) · Nature Medicine · doi:10.1038/nm1146 · Cited by 749 · see citing works
Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically
Thomas, M., Kalita, A., Labrecque, S., Pim, D., Banks, L., & Matlashewski, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1092 · Cited by 700 · see citing works
Hussain, S. P., Schwank, J., Staib, F., Wang, X. W., & Harris, C. C. (2007) · Oncogene · doi:10.1038/sj.onc.1210279 · Cited by 623 · see citing works
Beyond Li Fraumeni Syndrome: Clinical Characteristics of Families With p53 Germline Mutations
Hagman, K. D. F., Noltner, K., Buzin, C. H., Gu, D., Wen, C. Y., Nguyen, V. Q., Han, J., Lowstuter, K. J., Longmate, J., Sommer, S. S., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.16.6959 · Cited by 607 · see citing works
Aristolochic acid and the etiology of endemic (Balkan) nephropathy
Grollman, A. P., Shibutani, S., Moriya, M., Miller, F. W., Wu, L., Moll, U. M., Suzuki, N., Fernandes, A., Rosenquist, T. A., Medverec, Z., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701248104 · Cited by 603 · see citing works
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.
Olivier, M., Langer√∏d, A., Carrieri, P., Bergh, J. C. S., Klaar, S., Eyfjord, J. E., Theillet, C. G., Rodríguez, C., Lidereau, R., Bièche, I., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1029 · Cited by 590 · see citing works
Self-citationRibeiro, R. C., Sandrini, F., Figueiredo, B., Zambetti, G. P., Michalkiewicz, E., Lafferty, A. R., DeLacerda, L., Rabin, M., Cadwell, C., Sampaio, G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161479898 · Cited by 541 · see citing works
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
Marín, M. C., Jost, C. A., Brooks, L. A., Irwin, M. S., O’Nions, J., TIDY, J. A., James, N. D., McGregor, J., Harwood, C. A., Yuluğ, I. G., et al. (2000) · Nature Genetics · doi:10.1038/75586 · Cited by 511 · see citing works
Olivier, M., Goldgar, D. E., Sodha, N., Ohgaki, H., Kleihues, P., Hainaut, P. L., & Eeles, R. A. (2003) · PubMed · Cited by 480 · see citing works
Self-citationRelative frequency and morphology of cancers in carriers of germline TP53 mutations
Birch, J. M., Alston, R. D., McNally, R. J., Evans, D. G. R., Kelsey, A. M., Harris, M., Eden, O. B., & Varley, J. M. (2001) · Oncogene · doi:10.1038/sj.onc.1204621 · Cited by 467 · see citing works
Bergh, J. C. S., Norberg, T., Sjögren, S., Lindgren, A., & Holmberg, L. (1995) · Nature Medicine · doi:10.1038/nm1095-1029 · Cited by 459 · see citing works
Bergamaschi, D., Gasco, M., Hiller, L., Sullivan, A., Syed, N., Trigiante, G., Yuluğ, I. G., Merlano, M. C., Numico, G., Comino, A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00079-5 · Cited by 445 · see citing works
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Song, H., Hollstein, M., & Xu, Y. (2007) · Nature Cell Biology · doi:10.1038/ncb1571 · Cited by 442 · see citing works
Bullock, A. N., Henckel, J., & Fersht, A. R. (2000) · Oncogene · doi:10.1038/sj.onc.1203434 · Cited by 435 · see citing works
p53 polymorphic variants at codon 72 exert different effects on cell cycle progression
Pim, D., & Banks, L. (2003) · International Journal of Cancer · doi:10.1002/ijc.11548 · Cited by 411 · see citing works
Hinds, P. W., Finlay, C. A., Quartin, R. S., Baker, S. J., Fearon, E. R., Vogelstein, B., & Levine, A. J. (1990) · PubMed · Cited by 408 · see citing works
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Boeckler, F. M., Joerger, A. C., Jaggi, G., Rutherford, T. J., Veprintsev, D. B., & Fersht, A. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805326105 · Cited by 389 · see citing works
Is p53 Polymorphism Maintained by Natural Selection?
Beckman, G., Birgander, R., lander, A. S. A., Saha, N., Holmberg, P., Kivelä, A., & Beckman, L. E. (1994) · Human Heredity · doi:10.1159/000154228 · Cited by 362 · see citing works
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs
Joerger, A. C., Ang, H. C., & Fersht, A. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607286103 · Cited by 354 · see citing works
Stephens, P., Edkins, S., Davies, H. R., Greenman, C., Cox, C., Hunter, C., Bignell, G. R., Teague, J. W., Smith, R., Stevens, C., et al. (2005) · Nature Genetics · doi:10.1038/ng1571 · Cited by 333 · see citing works
TP53 mutations in human skin cancers
Giglia‐Mari, G., & Sarasin, A. R. (2003) · Human Mutation · doi:10.1002/humu.10179 · Cited by 293 · see citing works
A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
DiGiammarino, E. L., Lee, A. S., Cadwell, C., Zhang, W., Bothner, B. B., Ribeiro, R. C., Zambetti, G. P., & Kriwacki, R. W. (2001) · Nature Structural Biology · doi:10.1038/nsb730 · Cited by 293 · see citing works
TP53mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Langerød, A., Zhao, H., Borgan, Ø., Nesland, J. M., Bukholm, I. R., Ikdahl, T., Kåresen, R., Børresen‐Dale, A., & Jeffrey, S. S. (2007) · Breast Cancer Research · doi:10.1186/bcr1675 · Cited by 291 · see citing works
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner
Bond, G. L., Hirshfield, K. M., Kirchhoff, T., Alexe, G., Bond, E. E., Robins, H., Bartel, F., Taubert, H., Wuerl, P., Hait, W., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0180 · Cited by 287 · see citing works
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
Wu, X. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.9.681 · Cited by 249 · see citing works
Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide Analogs
Bykov, V. J. N., Issaeva, N., Zache, N., Shilov, A., Hultcrantz, M., Bergman, J., Selivanova, G., & Wiman, K. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501664200 · Cited by 247 · see citing works
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo
Sullivan, A., Syed, N., Gasco, M., Bergamaschi, D., Trigiante, G., Attard, M., Hiller, L., Farrell, P. J., Smith, P., Lü, X., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207428 · Cited by 247 · see citing works
TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer.
Olivier, M., Hussain, S. P., de Fromentel, C. C., Hainaut, P. L., & Harris, C. C. (2004) · PubMed · Cited by 243 · see citing works
Self-citationScreening patients for heterozygous p53 mutations using a functional assay in yeast
Ishioka, C., Frébourg, T., Yan, Y.-X., Vidal, M., Friend, S. H., Schmidt, S., & Iggo, R. D. (1993) · Nature Genetics · doi:10.1038/ng1093-124 · Cited by 243 · see citing works
Ory, K., Legros, Y., Auguin, C., & Soussi, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06656.x · Cited by 229 · see citing works
Achatz, M. I., Olivier, M., Calvez‐Kelm, F. L., Martel‐Planche, G., Lopes, A., Rossi, B. M., Ashton‐Prolla, P., Giugliani, R., Palmero, E. I., Vargas, F. R., et al. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.12.039 · Cited by 218 · see citing works
Self-citationGemignani, F., Moreno, V. R., Landi, S., Moullan, N., Chabrier, A., Gutiérrez‐Enríquez, S., Hall, J. A., Guinó, E., Peinado, M. A., Capellá, G., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207305 · Cited by 217 · see citing works
Bougeard, G., Baert-Desurmont, S., Tournier, I., Vasseur, S., Martin, C., Brugières, L., Chompret, A., Paillerets, B. B., Stoppa‐Lyonnet, D., Bonaïti‐Pellié, C., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.037952 · Cited by 216 · see citing works
Germline mutations in the TP53 gene.
Eeles, R. A. (1995) · PubMed · Cited by 213 · see citing works
Characterization of genome-wide p53-binding sites upon stress response
Smeenk, L., van Heeringen, S. J., Koeppel, M., van Driel, M. A., Bartels, S. J. J., Akkers, R. C., Denissov, S., Stunnenberg, H. G., & Lohrum, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn232 · Cited by 211 · see citing works
Langerød, A., Bukholm, I., Bregård, A., Lønning, P. E., Andersen, T. I., Rognum, T. O., Meling, G. I., Lothe, R. A., & Børresen‐Dale, A. (2002) · PubMed · Cited by 204 · see citing works
Methylation, mutation and cancer
Jones, P. A., Rideout, W. M., Shen, J., Spruck, C., & Tsai, Y. (1992) · BioEssays · doi:10.1002/bies.950140107 · Cited by 202 · see citing works
Birch, J. M., Blair, V., Kelsey, A. M., Evans, D. G., Harris, M., Tricker, K. J., & Varley, J. M. (1998) · Oncogene · doi:10.1038/sj.onc.1202033 · Cited by 200 · see citing works
Inga, A., Storici, F., Darden, T. A., & Resnick, M. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8612-8625.2002 · Cited by 200 · see citing works
Structures of p53 Cancer Mutants and Mechanism of Rescue by Second-site Suppressor Mutations
Joerger, A. C., Ang, H. C., Veprintsev, D. B., Blair, C. M., & Fersht, A. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500179200 · Cited by 181 · see citing works
BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives
Lalloo, F. I., Varley, J. M., Moran, A., Ellis, D., O’Dair, L., Pharoah, P. D. P., Antoniou, A. C., Hartley, R., Shenton, A., Seal, S., et al. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2005.11.032 · Cited by 175 · see citing works
Arlt, V. M., Stiborová, M., Brocke, J. V., Simões, M. L., Lord, G. M., Nortier, J., Hollstein, M., Phillips, D. H., & Schmeiser, H. H. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm082 · Cited by 173 · see citing works
Bonafè, M., Ceccarelli, C., Farabegoli, F., Santini, D., Taffurelli, M., Barbi, C., Marzi, E., Trapassi, C., Storci, G., Olivieri, F., et al. (2003) · PubMed · Cited by 171 · see citing works
Dominant-negative p53 mutations selected in yeast hit cancer hot spots.
Brachmann, R. K., Vidal, M., & Boeke, J. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4091 · Cited by 159 · see citing works
TP53 polymorphisms and lung cancer risk: a systematic review and meta-analysis
Matakidou, A. (2003) · Mutagenesis · doi:10.1093/mutage/geg008 · Cited by 150 · see citing works
p53 Codon 72 Polymorphism and Cervical Neoplasia
Koushik, A., Platt, R. W., & Franco, E. L. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-083-3 · Cited by 146 · see citing works
Dearth, L. R., Hua, Q., Wang, T., Baroni, T. E., Zeng, J., Chen, S. W., Yi, S. Y., & Brachmann, R. K. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl132 · Cited by 139 · see citing works
p53 polymorphism and risk of cervical cancer
Helland, Å., Langerød, A., Johnsen, H., Olsen, A. O., Skovlund, E., & Børresen‐Dale, A. (1998) · Nature · doi:10.1038/25034 · Cited by 134 · see citing works
Luo, J., Yang, Q., Tong, W., Hergenhahn, M., Wang, Z., & Hollstein, M. C. (2001) · Oncogene · doi:10.1038/sj.onc.1204080 · Cited by 133 · see citing works
Trp53-dependent DNA-repair is affected by the codon 72 polymorphism
Siddique, M. M., & Sabapathy, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209405 · Cited by 130 · see citing works
Ser46 Phosphorylation Regulates p53-Dependent Apoptosis and Replicative Senescence
Feng, L., Hollstein, M., & Xu, Y. (2006) · Cell Cycle · doi:10.4161/cc.5.23.3526 · Cited by 119 · see citing works
Prevalence of Early Onset Colorectal Cancer in 397 Patients With Classic Li–Fraumeni Syndrome
Wong, P., Verselis, S. J., Garber, J. E., Schneider, K. A., DiGianni, L. M., Stockwell, D. H., Li, F. P., & Syngal, S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.014 · Cited by 111 · see citing works
Molecular pathology in basal cell cancer with p53 as a genetic marker
Pontén, F., Berg, C., Ahmadian, A., Ren, Z.-P., Nistér, M., Lundeberg, J., Uhlén, M., & Pontén, J. (1997) · Oncogene · doi:10.1038/sj.onc.1201435 · Cited by 110 · see citing works
Jia, L., Liu, Y., Yi, X., Miron, A., Crum, C. P., Kong, B., & Zheng, W. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4837 · Cited by 110 · see citing works
TP53 Status and Response to Chemotherapy in Breast Cancer
Bertheau, P., Espié, M., Turpin, E., Lehmann‐Che, J., Plassa, L., Varna, M., Janin, A., & de Thé, H. (2008) · Pathobiology · doi:10.1159/000123851 · Cited by 108 · see citing works
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Schmütte, C., Yang, A. S., Nguyen, T. T., Beart, R. W., & Jones, P. A. (1996) · PubMed · Cited by 104 · see citing works
Xu, Y., Yao, L., Ouyang, T., Li, J., Wang, T., Fan, Z., Lin, B., Lu, Y., & Xie, Y. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0507 · Cited by 102 · see citing works
Bull, S. B., Özçelik, H., Pinnaduwage, D., Blackstein, M. E., Sutherland, D. A. J., Pritchard, K. I., Tzontcheva, A., Sidlofsky, S., Hanna, W. M., Qizilbash, A. H., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.128 · Cited by 99 · see citing works
A nucleotide substitution model with nearest-neighbour interactions
Lunter, G. A., & Hein, J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth901 · Cited by 89 · see citing works
On the origin of G→T transversions in lung cancer
Pfeifer, G. P., & Hainaut, P. L. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(03)00013-7 · Cited by 86 · see citing works
Self-citationp53 germline polymorphisms are associated with an increased risk for breast cancer in German women.
Wang‐Gohrke, S., Rebbeck, T. R., Besenfelder, W., Kreienberg, R., & Runnebaum, I. B. (1998) · PubMed · Cited by 84 · see citing works
de Fromentel, C. C., Gruel, N., Venot, C., Debüssche, L., Conseiller, E., Dureuil, C., Teillaud, J., Tocqué, B., & Bracco, L. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202338 · Cited by 83 · see citing works
Nedelko, T., Arlt, V. M., Phillips, D. H., & Hollstein, M. C. (2008) · International Journal of Cancer · doi:10.1002/ijc.24006 · Cited by 82 · see citing works
Bougeard, G., Brugières, L., Chompret, A., Gesta, P., Charbonnier, F., Valent, A., Martin, C., Raux, G., Feunteun, J., Paillerets, B. B., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206155 · Cited by 80 · see citing works
Schneider‐Stock, R., Mawrin, C., Motsch, C., Boltze, C., Peters, B., Hartig, R., Buhtz, P., Giers, A., Rohrbeck, A., Freigang, B., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63211-7 · Cited by 76 · see citing works
Vikhanskaya, F., Siddique, M. M., Lee, M. K., Broggini, M., & Sabapathy, K. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1547 · Cited by 75 · see citing works
TP53 mutations in early-stage ovarian carcinoma, relation to long-term survival
Wang, Y., Helland, Å., Holm, R., Skomedal, H., Abeler, V. M., Danielsen, H. E., Tropé, C., Børresen-Dale, A.-L., & Kristensen, G. B. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601537 · Cited by 68 · see citing works
Wang‐Gohrke, S., Weikel, W., Risch, H. A., Vesprini, D., Abrahamson, J., Lerman, C., Godwin, A. K., Moslehi, R., Olipade, O., Brunet, J., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690669 · Cited by 67 · see citing works
TP53 mutation, allelism and survival in non-small cell lung cancer
Nelson, H. H., Wilkojmen, M., Marsit, C. J., & Kelsey, K. T. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi125 · Cited by 66 · see citing works
A functional screen for germ line p53 mutations based on transcriptional activation.
Frébourg, T., Barbier, N., Kassel, J., Ng, Y. S., Beer‐Romero, P., & Friend, S. H. (1992) · PubMed · Cited by 64 · see citing works
TP53 polymorphism, HPV infection, and risk of cervical cancer.
Klug, S. J., Wilmotte, R., Santos, C., Almonte, M., Herrero, R., Guerrero, I., Caceres, E., Guimarães, D. P., Lenoir, G., Hainaut, P. L., et al. (2001) · PubMed · Cited by 55 · see citing works
Self-citationWang, Y., Kringen, P., Kristensen, G. B., Holm, R., Baekelandt, M. M. O., Olivier, M., Skomedal, H., Hainaut, P. L., Trope, C. G., Abeler, V. M., et al. (2004) · Human Mutation · doi:10.1002/humu.20055 · Cited by 52 · see citing works
Self-citationTP53 and P21 polymorphisms: Response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer
Santos, A. M., de Sousa, H. M. L., Portela, C. L., Pereira, D., Pinto, D., Catarino, R., Rodrigues, C., Araújo, A. P., Lopes, C., & Medeiros, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.176 · Cited by 51 · see citing works
MEF immortalization to investigate the ins and outs of mutagenesis
Brocke, J. V., Schmeiser, H. H., Reinbold, M., & Hollstein, M. C. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl101 · Cited by 48 · see citing works
Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72
Reinbold, M., Luo, J.-L., Nedelko, T., Jerchow, B., Murphy, M. E., Whibley, C. E., Wei, Q., & Hollstein, M. C. (2007) · Oncogene · doi:10.1038/sj.onc.1210932 · Cited by 43 · see citing works
Kochethu, G., Delgado, J., Pepper, C. J., Starczynski, J., Hooper, L., Krishnan, S., Fegan, C., & Pratt, G. (2006) · Leukemia Research · doi:10.1016/j.leukres.2005.12.014 · Cited by 34 · see citing works
Molecular precursor lesions in oesophageal cancer.
Montesano, R., & Hainaut, P. L. (1998) · PubMed · Cited by 34 · see citing works
Self-citationPistritto, G., Puca, R., Nardinocchi, L., Sacchi, A., & D’Orazi, G. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402186 · Cited by 30 · see citing works
Clonal Analysis of Colorectal Tumors Using K-ras and p53 Gene Mutations as Markers
Dix, B. R., Robbins, P., Spagnolo, D. V., Padovan, G. L., House, A. K., & Iacopetta, B. J. (1995) · Diagnostic Molecular Pathology · doi:10.1097/00019606-199512000-00006 · Cited by 29 · see citing works
Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene
Dudgeon, C., Kek, C., Demidov, O. N., Saito, S., Fernandes, K., Diot, A., Bourdon, J., Lane, D. P., Appella, E., Fornace, A. J., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2063 · Cited by 25 · see citing works
p53 polymorphic variants at codon 72 and the outcome of therapy in randomized breast cancer patients
Wegman, P., Stål, O., Stenmark‐Askmalm, M., Nordenskjöld, B. A., Rutqvist, L., & Wingren, S. (2006) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000204997.84182.69 · Cited by 23 · see citing works
p53 Designer Genes for the Modern Mouse
Hergenhahn, M., Luo, J., & Hollstein, M. (2004) · Cell Cycle · doi:10.4161/cc.3.6.890 · Cited by 18 · see citing works
Calvez‐Kelm, F. L., Ahman, A., Tõnisson, N., Lambert, J., Temam, S., Brennan, P., Zaridze, D. G., Metspalu, A., & Hainaut, P. L. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.048348 · Cited by 18 · see citing works
Self-citationA double germline mutations in the APC and p53 genes.
Zajac, Tomka, M., Ilenčíková, D., Májek, P., Števurková, V., & Kirchhoff, T. (2000) · PubMed · Cited by 10 · see citing works
Single-Nucleotide Polymorphisms in the p53 PathwayPreprint
Harris, S. L., Gil, G. A., Hu, W., Robins, H. S., Bond, E. E., Hirshfield, K. M., Feng, Z., YU, X., Teresky, A. K., Bond, G. L., et al. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.024 · Cited by 9 · see citing works
Mouse models for generating P53 gene mutation spectra
Zielinski, B., Liu, Z., Hollstein, M. C., Hergenhahn, M., & Luo, J. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00160-1 · Cited by 5 · see citing works
Langerød, A., Zhao, H., Borgan, Ø., Jm, N., Hernandez‐Boussard, T., Bukholm, I., Kåresen, R., Børresen‐Dale, A., & Jeffrey, S. S. (2005) · Breast Cancer Research · doi:10.1186/bcr1174 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163 · see citing works
TP53 mutations in human cancers: origins, consequences, and clinical use.
Olivier, M., Hollstein, M., & Hainaut, P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001008 · Cited by 2,199 · see citing works
Self-citationŁukasiewicz, S., Czeczelewski, M., Forma, A., Baj, J., Sitarz, R., & Stanisławek, A. (2021) · Cancers · doi:10.3390/cancers13174287 · Cited by 2,143 · see citing works
Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
Muller, P. A. J., & Vousden, K. H. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.021 · Cited by 1,545 · see citing works
Mutant p53: one name, many proteinsPreprint
Freed-Pastor, W. A., & Prives, C. L. (2012) · Genes & Development · doi:10.1101/gad.190678.112 · Cited by 1,246 · see citing works
When mutants gain new powers: News from the mutant p53 field
Brosh, R., & Rotter, V. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2693 · Cited by 1,132 · see citing works
Rivlin, N., Brosh, R., Oren, M., & Rotter, V. (2011) · Genes & Cancer · doi:10.1177/1947601911408889 · Cited by 1,033 · see citing works
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Freed-Pastor, W. A., Mizuno, H., Zhao, X., Langerød, A., Moon, S.-H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.017 · Cited by 865 · see citing works
Mutant p53 drives invasion by promoting integrin recycling
Muller, P. A. J., Caswell, P. T., Doyle, B., Iwanicki, M. P., Tan, E. H., Karim, S., Lukashchuk, N., Gillespie, D. A., Ludwig, R. L., Gosselin, P., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.026 · Cited by 796 · see citing works
Mutant p53 Gain-of-Function in CancerPreprint
Oren, M., & Rotter, V. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001107 · Cited by 753 · see citing works
The interplay between cell signalling and the mevalonate pathway in cancer
Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 697 · see citing works
The genetics of the p53 pathway, apoptosis and cancer therapy
Vázquez, A., Bond, E. E., Levine, A. J., & Bond, G. L. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2656 · Cited by 674 · see citing works
Epidemiology of Glioblastoma Multiforme–Literature Review
Grochans, S., Cybulska, A. M., Simińska, D., Korbecki, J., Kojder, K., Chlubek, D., & Baranowska‐Bosiacka, I. (2022) · Cancers · doi:10.3390/cancers14102412 · Cited by 662 · see citing works
The expanding universe of p53 targets
Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568 · see citing works
The chemistry, physiology and pathology of pH in cancer
Swietach, P., Vaughan‐Jones, R. D., Harris, A. L., & Hulı́ková, A. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0099 · Cited by 542 · see citing works
Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others
Sabapathy, K., & Lane, D. P. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.151 · Cited by 517 · see citing works
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
Chen, X., Zhang, T., Su, W., Dou, Z., Zhao, D., Jin, X., Lei, H., Wang, J., Xie, X., Cheng, B., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05408-1 · Cited by 494 · see citing works
The p53 Pathway in Glioblastoma
Zhang, Y., Dube, C., Gibert, M., Cruickshanks, N., Wang, B., Coughlan, M., Yang, Y., Setiady, I., Deveau, C., Saoud, K., et al. (2018) · Cancers · doi:10.3390/cancers10090297 · Cited by 440 · see citing works
Structure–function–rescue: the diverse nature of common p53 cancer mutants
Joerger, A. C., & Fersht, A. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210291 · Cited by 430 · see citing works
The role of mutant p53 in human cancer
Goh, A. M., Coffill, C. R., & Lane, D. P. (2010) · The Journal of Pathology · doi:10.1002/path.2784 · Cited by 398 · see citing works
TP53 Mutations in Nonsmall Cell Lung Cancer
Mogi, A., & Kuwano, H. (2011) · BioMed Research International · doi:10.1155/2011/583929 · Cited by 392 · see citing works
Development and validation of a TP53-associated immune prognostic model for hepatocellular carcinoma
Long, J., Wang, A., Bai, Y., Lin, J., Yang, X., Wang, D., Yang, X., Jiang, Y., & Zhao, H. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.022 · Cited by 380 · see citing works
p53 Acetylation: Regulation and Consequences
Reed, S. M., & Quelle, D. E. (2014) · Cancers · doi:10.3390/cancers7010030 · Cited by 330 · see citing works
Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy
Yue, X., Zhao, Y., Xu, Y., Zheng, M., Feng, Z., & Hu, W. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.03.030 · Cited by 308 · see citing works
Emerging biomarkers in head and neck cancer in the era of genomics
Kang, H., Kiess, A. P., & Chung, C. H. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.192 · Cited by 311 · see citing works
Salama, A. K. S., Li, S., Macrae, E. R., Park, J., Mitchell, E. P., Zwiebel, J. A., Chen, H. X., Gray, R. J., McShane, L. M., Rubinstein, L., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00762 · Cited by 311 · see citing works
p53 and MicroRNA-34 Are Suppressors of Canonical Wnt Signaling
Kim, N. H., Kim, N.-G., Kim, N.-G., Lee, I., Choi, H.-S., Li, X.-Y., Kang, S. E., Cha, S. Y., Ryu, J. K., Na, J. M., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001744 · Cited by 308 · see citing works
Nuclear Receptor Coregulators and Human Disease
Lonard, D. M., Lanz, R. B., & O’Malley, B. W. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0012 · Cited by 303 · see citing works
Otmani, K., & Lewalle, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.708765 · Cited by 287 · see citing works
Mouse models of human AML accurately predict chemotherapy responsePreprint
Zuber, J. A., Radtke, I., Pardee, T. S., Zhao, Z., Rappaport, A., Luo, W., McCurrach, M. E., Yang, M., Dolan, M. E., Kogan, S. C., et al. (2009) · Genes & Development · doi:10.1101/gad.1771409 · Cited by 279 · see citing works
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C. D., Gao, J., Spitzer, B. G., Bosbach, B., Kastenhuber, E. R., Baslan, T., et al. (2016) · Nature · doi:10.1038/nature17157 · Cited by 272 · see citing works
Significance of immunohistochemistry in breast cancer
Zaha, D. C. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.382 · Cited by 277 · see citing works
Xiao, Y., Chen, J., Zhou, H., Zeng, X., Ruan, Z., Pu, Z., Jiang, X., Matsui, A., Zhu, L., Amoozgar, Z., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28279-8 · Cited by 267 · see citing works
Labbé, C., Cabanero, M., Korpanty, G. J., Tomasini, P., Doherty, M. K., Mascaux, C., Jao, K., Pitcher, B., Wang, R., Pintilie, M., et al. (2017) · Lung Cancer · doi:10.1016/j.lungcan.2017.06.014 · Cited by 230 · see citing works
Somatic TP53 Mutations in the Era of Genome SequencingPreprint
Hainaut, P. L., & Pfeifer, G. P. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026179 · Cited by 247 · see citing works
Self-citationp53 and its isoforms in cancer
Bourdon, J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603886 · Cited by 245 · see citing works
Messaoudi, K., Clavreul, A., & Lagarce, F. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.02.011 · Cited by 238 · see citing works
Mutant p53 in breast cancer: potential as a therapeutic target and biomarker
Duffy, M. J., Synnott, N. C., & Crown, J. P. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4753-7 · Cited by 234 · see citing works
Waarts, M. R., Stonestrom, A. J., Park, Y. C., & Levine, R. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154943 · Cited by 236 · see citing works
Shern, J. F., Selfe, J., Izquierdo, E., Patidar, R., Chou, H.-C., Song, Y., Yohe, M. E., Sindiri, S., Wei, J. S., Wen, X., et al. (2021) · Journal of Clinical Oncology · doi:10.1200/jco.20.03060 · Cited by 221 · see citing works
Chen, J. W., & Dhahbi, J. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-92725-8 · Cited by 208 · see citing works
Swarbrick, A., Woods, S. L., Shaw, A., Balakrishnan, A., Phua, Y. W., Nguyen, A., Chanthery, Y. H., Lim, L., Ashton, L. J., Judson, R. L., et al. (2010) · Nature Medicine · doi:10.1038/nm.2227 · Cited by 199 · see citing works
Yu, Y. H., Yang, L., Zhao, M., Zhu, S., Kang, R., Vernon, P. J., Tang, D., & Cao, L. (2012) · Leukemia · doi:10.1038/leu.2012.65 · Cited by 198 · see citing works
Tornesello, M. L., Buonaguro, L., Tatangelo, F., Botti, G., Izzo, F., & Buonaguro, L. (2013) · Genomics · doi:10.1016/j.ygeno.2013.04.001 · Cited by 196 · see citing works
Identification of a Cholangiocarcinoma-Like Gene Expression Trait in Hepatocellular Carcinoma
Woo, H. G., Lee, J., Yoon, J., Kim, C. Y., Lee, H., Jang, J. J., Yi, N., Suh, K., Lee, K. U., Park, E. S., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2823 · Cited by 191 · see citing works
Recent Advances in p53 Research and Cancer Treatment
Suzuki, K., & Matsubara, H. (2011) · BioMed Research International · doi:10.1155/2011/978312 · Cited by 187 · see citing works
Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium
Goebell, P. J., & Knowles, M. A. (2010) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2010.04.003 · Cited by 178 · see citing works
Sampson, J. N., Wheeler, W. A., Yeager, M., Panagiotou, O. A., Wang, Z., Berndt, S. I., Qing Lan, B., Abnet, C. C., Amundadottir, L. T., Figueroa, J. D., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv279 · Cited by 181 · see citing works
Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies
Xu-Monette, Z. Y., Medeiros, L. J., Li, Y., Orlowski, R. Z., Andreeff, M., Bueso-Ramos, C., Greiner, T. C., McDonnell, T. J., & Young, K. H. (2012) · Blood · doi:10.1182/blood-2011-11-366062 · Cited by 179 · see citing works
Mutational spectra of human cancer
Pfeifer, G. P., & Nia, A. B. (2009) · Human Genetics · doi:10.1007/s00439-009-0657-2 · Cited by 177 · see citing works
PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
Tessoulin, B., Descamps, G., Moreau, P., Maïga, S., Lodé, L., Godon, C., Marionneau-Lambot, S., Oullier, T., Le Gouill, S., Amiot, M., et al. (2014) · Blood · doi:10.1182/blood-2014-01-548800 · Cited by 166 · see citing works
Peng, X., Zhang, M.-Q.-Z., Conserva, F., Hosny, G., Selivanova, G., Bykov, V. J. N., Arnér, E. S. J., & Wiman, K. G. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.417 · Cited by 170 · see citing works
Hou, H.-A., Chou, W.-C., Kuo, Y.-Y., Liu, C.-Y., Lin, L., Tseng, M.-H., Chiang, Y.-C., Liu, M.-C., Liu, C.-W., Tang, J.-L., et al. (2015) · Blood Cancer Journal · doi:10.1038/bcj.2015.59 · Cited by 165 · see citing works
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
England, B., Huang, T., & Karsy, M. (2013) · Tumor Biology · doi:10.1007/s13277-013-0871-3 · Cited by 163 · see citing works
The role of DNA damage responses in p53 biology
Speidel, D. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1459-z · Cited by 165 · see citing works
de Andrade, K. C., Lee, E. E., Tookmanian, E. M., Kesserwan, C. A., Manfredi, J. J., Hatton, J. N., Loukissas, J. K., Zavadil, J., Zhou, L. J., Olivier, M., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00976-3 · Cited by 162 · see citing works
Self-citationRecent advances in p53 research: an interdisciplinary perspective
Olivier, M., Petitjean, A., Marcel, V., Pétré, A., Mounawar, M., Plymoth, A., de Fromentel, C. C., & Hainaut, P. L. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.69 · Cited by 161 · see citing works
Self-citationTP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies
Klug, S. J., Ressing, M., Koenig, J., Abba, M. C., Αγοραστός, Θ., Brenna, S. M. F., Ciotti, M., Das, B., Mistro, A. D., Dybikowska, A., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70187-1 · Cited by 158 · see citing works
Krimmel‐Morrison, J. D., Schmitt, M. W., Harrell, M. I., Agnew, K. J., Kennedy, S. R., Emond, M. J., Loeb, L. A., Swisher, E. M., & Risques, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601311113 · Cited by 155 · see citing works
Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors
Levy, C. B., Stumbo, A. C., Bom, A. P. D. A., Portari, E. A., Carneiro, Y., Silva, J. L., & Gallo, C. V. D. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.10.017 · Cited by 150 · see citing works
Allen, J. G., Bourbeau, M. P., Wohlhieter, G. E., Bartberger, M. D., Michelsen, K., Hungate, R. W., Gadwood, R. C., Gaston, R. D., Evans, B., Mann, L. W., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900681h · Cited by 148 · see citing works
Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer
Naccarati, A., Vymetalkova, V. P., Pardini, B., Vodičková, Ľ., Hemminki, K., Kumar, R., & Vodička, P. (2012) · Mutagenesis · doi:10.1093/mutage/ger067 · Cited by 143 · see citing works
Smith, J. C., & Sheltzer, J. M. (2018) · eLife · doi:10.7554/elife.39217 · Cited by 138 · see citing works
p53 Isoforms and Their Implications in Cancer
Vieler, M., & Sanyal, S. (2018) · Cancers · doi:10.3390/cancers10090288 · Cited by 140 · see citing works
Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis
Yogosawa, S., & Yoshida, K. (2018) · Cancer Science · doi:10.1111/cas.13792 · Cited by 139 · see citing works
Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53Preprint
Pfister, N. T., & Prives, C. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026054 · Cited by 139 · see citing works
Early onset HER2‐positive breast cancer is associated with germline TP53 mutations
Melhem‐Bertrandt, A., Bojadzieva, J., Ready, K. J., Obeid, E. I., Liu, D. D., Gutierrez‐Barrera, A. M., Litton, J. K., Olopade, O. I., Hortobágyi, G. N., Strong, L. C., et al. (2011) · Cancer · doi:10.1002/cncr.26377 · Cited by 137 · see citing works
Perrone, F., Bossi, P., Cortelazzi, B., Locati, L. D., Quattrone, P., Pierotti, M. A., Pilotti, S., & Licitra, L. F. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4170 · Cited by 137 · see citing works
Tan, B. S., Tiong, K. H., Choo, H. L., Chung, F. F., Hii, L., Tan, S. H., Yap, I. K., Pani, S., Khor, N. T., Wong, S. F., et al. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.191 · Cited by 137 · see citing works
Peng, X., Zhang, M., Conserva, F., Hosny, G., Selivanova, G., Bykov, V. J. N., Arnér, E. S. J., & Wiman, K. G. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.137 · Cited by 134 · see citing works
Mevalonate Pathway and Human Cancers
Tamanoi, F., Azizian, M., Ashrafi, M., & Bathaie, S. Z. (2016) · Current Molecular Pharmacology · doi:10.2174/1874467209666160112123205 · Cited by 132 · see citing works
TP53mutations, expression and interaction networks in human cancers
Wang, X., & Sun, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.13483 · Cited by 132 · see citing works
Nadauld, L. D., Garcia, S., Natsoulis, G., Bell, J., Miotke, L. K., Hopmans, E. S., Xu, H., Pai, R. K., Palm, C., Regan, J. F., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0428-9 · Cited by 126 · see citing works
What is pH regulation, and why do cancer cells need it?
Swietach, P. (2019) · Cancer and Metastasis Reviews · doi:10.1007/s10555-018-09778-x · Cited by 128 · see citing works
The impact of p53 and p73 on aneuploidy and cancer
Tomasini, R., Mak, T. W., & Melino, G. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.03.003 · Cited by 126 · see citing works
Berg, M., Danielsen, S. A., Ahlquist, T. C., Merok, M. A., Ågesen, T. H., Vatn, M. H., Mala, T., Sjo, O. H., Bakka, A. O., Moberg, I. O., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013978 · Cited by 125 · see citing works
Wang, W., Cheng, B., Miao, L., Mei, Y., & Wu, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.97 · Cited by 124 · see citing works
Kovács, D., Igaz, N., Keskeny, C., Bélteky, P., Tóth, T., Gáspár, R., Madarász, D., Rázga, Z., Kónya, Z., Boros, I., et al. (2016) · Scientific Reports · doi:10.1038/srep27902 · Cited by 124 · see citing works
Activation of Lung p53 by Nutlin-3a Prevents and Reverses Experimental Pulmonary Hypertension
Mouraret, N., Marcos, É., Abid, S., Gary‐Bobo, G., Saker, M., Houssaini, A., Dubois‐Randé, J., Boyer, L., Boczkowski, J., Dérumeaux, G., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.002434 · Cited by 124 · see citing works
Hanna, G. J., Busaidy, N. L., Chau, N. G., Wirth, L. J., Barletta, J. A., Calles, A., Haddad, R. I., Kraft, S., Cabanillas, M. E., Rabinowits, G., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2297 · Cited by 123 · see citing works
MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity
Xue, J., Chi, Y., Chen, Y., Huang, S., Ye, X., Niu, J., Wang, W., Pfeffer, L. M., Shao, Z.-M., Wu, Z.-H., et al. (2015) · Oncogene · doi:10.1038/onc.2015.96 · Cited by 121 · see citing works
Ruocco, E., Ruocco, V., Tornesello, M. L., Gambardella, A., Wolf, R., & Buonaguro, L. (2013) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2013.01.008 · Cited by 121 · see citing works
Immunohistochemical correlates of TP53 somatic mutations in cancer
Murnyák, B., & Hortobágyi, T. (2016) · Oncotarget · doi:10.18632/oncotarget.11912 · Cited by 116 · see citing works
Xu, F., Lin, H., He, P., He, L., Chen, J., Lin, L., & Chen, Y. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1731943 · Cited by 114 · see citing works
Targeting the Checkpoint to Kill Cancer Cells
Benada, J., & Macůrek, L. (2015) · Biomolecules · doi:10.3390/biom5031912 · Cited by 110 · see citing works
Bourdon, J., Khoury, M. P., Diot, A., Baker, L., Fernandes, K., Aoubala, M., Quinlan, P., Purdie, C. A., Jordan, L. B., Prats, A., et al. (2011) · Breast Cancer Research · doi:10.1186/bcr2811 · Cited by 110 · see citing works
Translation acrobatics: how cancer cells exploit alternate modes of translational initiation
Sriram, A., Bohlen, J., & Teleman, A. A. (2018) · EMBO Reports · doi:10.15252/embr.201845947 · Cited by 110 · see citing works
Li, Y., Chen, H., Hardy, T. M., & Tollefsbol, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054369 · Cited by 109 · see citing works
Widespread parainflammation in human cancer
Aran, D., Lasry, A., Zinger, A., Biton, M., Pikarsky, E., Hellman, A., Butte, A. J., & Ben‐Neriah, Y. (2016) · Genome biology · doi:10.1186/s13059-016-0995-z · Cited by 104 · see citing works
WEE1 Inhibitor: Clinical Development
Kong, A. H., & Mehanna, H. M. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01098-8 · Cited by 108 · see citing works
Alsner, J., Jensen, V., Kyndi, M., Offersen, B. V., Vu, P., Børresen‐Dale, A., & Overgaard, J. (2008) · Acta Oncologica · doi:10.1080/02841860802047411 · Cited by 107 · see citing works
Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome
Palmero, E. I., Achatz, M. I., Ashton‐Prolla, P., Olivier, M., & Hainaut, P. L. (2009) · Current Opinion in Oncology · doi:10.1097/cco.0b013e328333bf00 · Cited by 105 · see citing works
Self-citationTargeting prostate cancer based on signal transduction and cell cycle pathways
Lee, J. T., Lehmann, B. D., Terrian, D. M., Chappell, W. H., Stivala, F., Libra, M., Martelli, A. M., Steelman, L. S., & McCubrey, J. A. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6166 · Cited by 104 · see citing works
Alterations of theTP53Gene in Gastric and Esophageal Carcinogenesis
Bellini, M. F., Cadamuro, A. C. T., Succi, M., Proença, M. A., & Silva, A. E. (2012) · BioMed Research International · doi:10.1155/2012/891961 · Cited by 104 · see citing works
Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53
Jordan, J. J., Menendez, D., Inga, A., Nourredine, M., Bell, D., & Resnick, M. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000104 · Cited by 103 · see citing works
Gain of Function of Mutant TP53 in Glioblastoma: Prognosis and Response to Temozolomide
Wang, X., Chen, J., Liu, J., You, C., Liu, Y., & Mao, Q. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3380-0 · Cited by 103 · see citing works
Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium
Mai, P. L., Malkin, D. M., Garber, J. E., Schiffman, J. D., Weitzel, J. N., Strong, L. C., Wyss, O., Locke, L., Means, V., Achatz, M. I., et al. (2012) · Cancer Genetics · doi:10.1016/j.cancergen.2012.06.008 · Cited by 103 · see citing works
Self-citationDeep Learning-Driven Lung Cancer Detection: Integrating Image Processing and Web-Based Visualization
Nisha, J. R., Abedin, M. J., Nahyan, N., Faruk, R., Hridi, T. E. F., & Ahammed, M. T. (2025) · IEEE International Conference on Quantum Photonics, Artificial Intelligence & Networking (QPAIN) · doi:10.1109/qpain66474.2025.11171755 · Cited by 103 · see citing works
Li, V. D., Li, K. H. L., & Li, J. T. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2817-z · Cited by 99 · see citing works
- Authors
- Petitjean, A., Achatz, M. I. W., Borresen-Dale, A. L., Hainaut, P., & Olivier, M.
- Affiliations
- Centre international de recherche sur le cancer (FR)
- Corresponding author
- Hainaut, P
- Venue
- Oncogene
- Published
- 2007-04-02
- Volume
- 26
- Issue
- 15
- Pages
- 2157-2165
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2042484101
- Cited by
- 884
- References
- 117
- Citations by year
- 2026: 16 · 2025: 29 · 2024: 29 · 2023: 50 · 2022: 55 · 2021: 52 · 2020: 50 · 2019: 53 · 2018: 60 · 2017: 46 · 2016: 57 · 2015: 52 · 2014: 53 · 2013: 43 · 2012: 48
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- TP53 mutation, missense mutations, dominant-negative p53, gain-of-function, mutagenesis, tumor phenotype, cancer prognosis, Li-Fraumeni syndrome, loss of heterozygosity, breast cancer
- MeSH terms
- Genetic Markers, Humans, Mutation, Neoplasms, Polymorphism, Genetic, Prognosis, Biomarkers, Tumor, Tumor Suppressor Protein p53, Mutagenesis, Li-Fraumeni Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review