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Cited by 298

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

RNA polymerase II transcription initiation: A structural view

Open access
Nikolov, D. B., Burley, S. K.·1997·Proceedings of the National Academy of Sciences

Abstract

In eukaryotes, RNA polymerase II transcribes messenger RNAs and several small nuclear RNAs. Like RNA polymerases I and III, polymerase II cannot act alone. Instead, general initiation factors [transcription factor (TF) IIB, TFIID, TFIIE, TFIIF, and TFIIH] assemble on promoter DNA with polymerase II, creating a large multiprotein–DNA complex that supports accurate initiation. Another group of accessory factors, transcriptional activators and coactivators, regulate the rate of RNA synthesis from each gene in response to various developmental and environmental signals. Our current knowledge of this complex macromolecular machinery is reviewed in detail, with particular emphasis on insights gained from structural studies of transcription factors.

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Metadata

Authors
Nikolov, D. B., & Burley, S. K.
Venue
Proceedings of the National Academy of Sciences
Published
1997-01-07
Volume
94
Issue
1
Pages
15-22
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1988795249
Cited by
298
References
58
FWCI
6.41
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: RNA polymerase II transcription initiation: A structural view. https://app.cochat.ai/papers/10.1073/pnas.94.1.15
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Nikolov, D. B., & Burley, S. K. (1997). RNA polymerase II transcription initiation: A structural view. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.1.15

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