The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ligand binding was acquired during evolution of nuclear receptors
Open accessAbstract
The nuclear receptor (NR) superfamily comprises, in addition to ligand-activated transcription factors, members for which no ligand has been identified to date. We demonstrate that orphan receptors are randomly distributed in the evolutionary tree and that there is no relationship between the position of a given liganded receptor in the tree and the chemical nature of its ligand. NRs are specific to metazoans, as revealed by a screen of NR-related sequences in early- and non-metazoan organisms. The analysis of the NR gene duplication pattern during the evolution of metazoans shows that the present NR diversity arose from two waves of gene duplications. Strikingly, our results suggest that the ancestral NR was an orphan receptor that acquired ligand-binding ability during subsequent evolution.
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Cites
Sponge phylogeny, animal monophyly, and the origin of the nervous system: 18S rRNA evidence
Cavalier-Smith, T., Allsopp, M. T. E. P., Chao, E. E., Boury-Esnault, N., & Vacelet, J. (1996) · Canadian Journal of Zoology · doi:10.1139/z96-231 · Cited by 180
Cited by
Ecotoxicology of human pharmaceuticals
Fent, K., Weston, A. A., & Caminada, D. (2006) · Aquatic Toxicology · doi:10.1016/j.aquatox.2005.09.009 · Cited by 3,223
Varga, T., Czimmerer, Z., & Nagy, L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.014 · Cited by 933
Overview of nomenclature of nuclear receptors
Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688
Self-citationPeterson, K. J., & Eernisse, D. J. (2001) · Evolution & Development · doi:10.1046/j.1525-142x.2001.003003170.x · Cited by 529
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491
Metadata
- Authors
- Escriva, H., Safi, R., Hänni, C., Langlois, M.-C., Saumitou-Laprade, P., Stehelin, D., Capron, A., Pierce, R., & Laudet, V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-06-24
- Volume
- 94
- Issue
- 13
- Pages
- 6803-6808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109894071
- Cited by
- 403
- References
- 1
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Ligand binding was acquired during evolution of nuclear receptors. https://app.cochat.ai/papers/10.1073/pnas.94.13.6803
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- Escriva, H., Safi, R., Hänni, C., Langlois, M.-C., Saumitou-Laprade, P., Stehelin, D., Capron, A., Pierce, R., & Laudet, V. (1997). Ligand binding was acquired during evolution of nuclear receptors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.13.6803
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
