The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Role for Bcl-xLas an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
Open accessAbstract
Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-x L fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stress. Coimmunoprecipitation studies demonstrate that Bcl-x L associates with cytochrome C. Cytochrome C binds directly and specifically to Bcl-x L and not to the proapoptotic Bcl-x s protein. The results also demonstrate that Bcl-x s blocks binding of cytochrome C to Bcl-x L. Our findings support a role for Bcl-x L in protecting cells from apoptosis by inhibiting the availability of cytochrome C in the cytosol.
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Cites
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
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p53 is required for radiation-induced apoptosis in mouse thymocytes
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Thymocyte apoptosis induced by p53-dependent and independent pathways
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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
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Cited by
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,760
Targeting apoptosis in cancer therapy
Carneiro, B. A., & El-Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,542
Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,292
Metadata
- Authors
- Kharbanda, S., Pandey, P., Schofield, L., Israels, S., Roncinske, R., Yoshida, K., Bharti, A., Yuan, Z.-M., Saxena, S., Weichselbaum, R., Nalin, C., & Kufe, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-06-24
- Volume
- 94
- Issue
- 13
- Pages
- 6939-6942
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2090202756
- Cited by
- 393
- References
- 27
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Kharbanda, S., Pandey, P., Schofield, L., Israels, S., Roncinske, R., Yoshida, K., Bharti, A., Yuan, Z.-M., Saxena, S., Weichselbaum, R., Nalin, C., & Kufe, D. (1997). Role for Bcl-xLas an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.13.6939
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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