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Induction of host signal transduction pathways by Helicobacter pylori
Open accessAbstract
Adherence of Helicobacter pylori to cultured gastric epithelial cells is associated with several cellular events, including the tyrosine phosphorylation of a 145-kDa host protein; the reorganization of the host cell actin and associated cellular proteins, like vasodilator-stimulated phosphoprotein, adjacent to the attached bacterial cell; and the subsequent release of the cytokine, interleukin 8 (IL-8). H. pylori isolated from patients with ulcer disease and gastric cancer contain a DNA insertion, the cag pathogenicity island (PAI), that is not present in bacteria isolated from individuals with asymptomatic infection. Mutations in a number of PAI genes abolish tyrosine phosphorylation and IL-8 synthesis but not the cytoskeletal rearrangements. Kinase inhibition studies suggest there are two distinct pathways operative in stimulating IL-8 release from host cells and one of these H. pylori pathways is independent of the tyrosine phosphorylation step.
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Citations
Cited by
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Inflammation, atrophy, and gastric cancer
Fox, J. G., & Wang, T. C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30111 · Cited by 772
Segal, E. D., Cha, J., Lo, J., Falkow, S., & Tompkins, L. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14559 · Cited by 770
Self-citationFalk, P. G., Hooper, L. V., Midtvedt, T., & Gordon, J. I. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1157-1170.1998 · Cited by 657
Host-Bacterial Interactions in Helicobacter pylori Infection
Amieva, M. R., & El–Omar, E. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.009 · Cited by 632
Metadata
- Authors
- Segal, E. D., Lange, C., Covacci, A., Tompkins, L. S., & Falkow, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-08
- Volume
- 94
- Issue
- 14
- Pages
- 7595-7599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2063732910
- Cited by
- 200
- References
- 0
- FWCI
- 24.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Segal, E. D., Lange, C., Covacci, A., Tompkins, L. S., & Falkow, S. (1997). Induction of host signal transduction pathways by Helicobacter pylori. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.14.7595
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