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Cited by 772

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Inflammation, atrophy, and gastric cancer

Open access
Fox, James G., Wang, Timothy C.·2007·Journal of Clinical Investigation

Abstract

The association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic inflammation observed in many cancers, particularly those originating in the gastrointestinal system. A prime example is Helicobacter pylori, which infects 50% of the world's population and is now known to be responsible for inducing chronic gastric inflammation that progresses to atrophy, metaplasia, dysplasia, and gastric cancer. This Review provides an overview of recent progress in elucidating the bacterial properties responsible for colonization of the stomach, persistence in the stomach, and triggering of inflammation, as well as the host factors that have a role in determining whether gastritis progresses to gastric cancer. We also discuss how the increased understanding of the relationship between inflammation and gastric cancer still leaves many questions unanswered regarding recommendations for prevention and treatment.

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Metadata

Authors
Fox, J. G., & Wang, T. C.
Venue
Journal of Clinical Investigation
Published
2007-01-02
Volume
117
Issue
1
Pages
60-69
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2059574805
Cited by
772
References
99
FWCI
40.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Inflammation, atrophy, and gastric cancer. https://app.cochat.ai/papers/10.1172/jci30111
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Fox, J. G., & Wang, T. C. (2007). Inflammation, atrophy, and gastric cancer. Journal of Clinical Investigation. https://doi.org/10.1172/jci30111

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.