The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction
Open accessAbstract
Focal cerebral infarction (stroke) due to unilateral occlusion of the middle cerebral artery in mature rats produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. We found that biweekly intracisternal injection of basic fibroblast growth factor (bFGF; 0.5 μg/injection), a potent neurotrophic polypeptide, markedly enhanced recovery of sensorimotor function of the contralateral limbs during the first month after stroke without apparent adverse side effects. Immunostaining for growth-associated protein 43 (GAP-43), a molecular marker of axonal sprouting, showed a selective increase in GAP-43 immunoreactivity in the intact sensorimotor cortex contralateral to cerebral infarcts following bFGF treatment. These results show that bFGF treatment can enhance functional recovery after stroke, and that the mechanism may include stimulation of neuronal sprouting in the intact brain.
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Cites
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Cited by
Recommendations for Standards Regarding Preclinical Neuroprotective and Restorative Drug Development
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Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875
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Role of adaptive plasticity in recovery of function after damage to motor cortex
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Metadata
- Authors
- Kawamata, T., Dietrich, W. D., Schallert, T., Gotts, J. E., Cocke, R. R., Benowitz, L. I., & Finklestein, S. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-07-22
- Volume
- 94
- Issue
- 15
- Pages
- 8179-8184
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1984626876
- Cited by
- 296
- References
- 33
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. https://app.cochat.ai/papers/10.1073/pnas.94.15.8179
- The paper
- Kawamata, T., Dietrich, W. D., Schallert, T., Gotts, J. E., Cocke, R. R., Benowitz, L. I., & Finklestein, S. P. (1997). Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.15.8179
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
