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A micromachined device provides a new bend on fibroblast traction forces
Open accessAbstract
We have measured the traction forces generated by fibroblasts using a novel micromachined device that is capable of determining the subcellular forces generated by individual adhesive contacts. The front of migrating fibroblasts produced intermittent rearward forces whereas the tail produced larger forward directed forces. None of the forces were steady; they all had periodic fluctuations. The transition between forward and rearward traction forces occurred at the nucleus, not at the rear of the cell or the border between the endoplasm and the ectoplasm. We propose that the coupling of lamella extensions to fluctuating rearward tractions in front of the nuclear region move the front of a fibroblast forward, while force-facilitated release of rear adhesive contacts and anterior-directed tractions allow the region behind the nucleus to advance.
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Citations
Cited by
Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328
Self-citationThe relationship between force and focal complex development
Galbraith, C. G., Yamada, K. M., & Sheetz, M. P. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200204153 · Cited by 908
Self-citationAdhesion-Dependent Cell Mechanosensitivity
Bershadsky, A. D., Balaban, N. Q., & Geiger, B. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153011 · Cited by 874
Appreciating force and shape—the rise of mechanotransduction in cell biology
Iskratsch, T., Wolfenson, H., & Sheetz, M. P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3903 · Cited by 798
Self-citationFibroblasts and myofibroblasts in wound healing: Force generation and measurement
Li, B., & Wang, J. H.-C. (2011) · Journal of Tissue Viability · doi:10.1016/j.jtv.2009.11.004 · Cited by 594
Metadata
- Authors
- Galbraith, C. G., & Sheetz, M. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-08-19
- Volume
- 94
- Issue
- 17
- Pages
- 9114-9118
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158931259
- Cited by
- 400
- References
- 0
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Galbraith, C. G., & Sheetz, M. P. (1997). A micromachined device provides a new bend on fibroblast traction forces. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.17.9114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
