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Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells
Open accessAbstract
Among the four subtypes of Hodgkin disease (HD), lymphocyte-predominant (LP) HD is now generally considered as a separate entity. The B cell nature of the typical Hodgkin and Reed–Sternberg (HRS) cells and their variants (L and H, lymphocytic and histiocytic cells) in LP HD has long been suspected, but the question of whether these cells represent a true tumor clone is unclear. We previously demonstrated clonal Ig gene rearrangements in one case of LP HD. In the present study, five cases of LP HD were analyzed by micromanipulation of single HRS cells from frozen tissue sections and DNA amplification of rearranged Ig heavy chain genes from those cells. Clonal V gene rearrangements harboring somatic mutations were detected in each case. In three cases ongoing somatic mutation was evident. This shows that HRS cells in LP HD are a clonal tumor population derived from germinal center B cells. The pattern of somatic mutation indicates that HRS cells in LP HD are selected for antibody expression. This, and the presence of ongoing mutation discriminates LP from classical HD.
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Citations
Cited by
Mechanisms of B-cell lymphoma pathogenesis
Küppers, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1589 · Cited by 965
Self-citationThe biology of Hodgkin's lymphoma
Küppers, R. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2542 · Cited by 688
Self-citationGoossens, T., Klein, U., & Küppers, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2463 · Cited by 342
Self-citationLiso, A. (2006) · Blood · doi:10.1182/blood-2005-10-3949 · Cited by 84
Appel, B. E., Chen, L., Buxton, A. B., Hutchison, R. E., Hodgson, D. C., Ehrlich, P. F., Constine, L. S., & Schwartz, C. L. (2016) · Journal of Clinical Oncology · doi:10.1200/jco.2015.65.3469 · Cited by 77
Metadata
- Authors
- Braeuninger, A., Küppers, R., Strickler, J. G., Wacker, H.-H., Rajewsky, K., & Hansmann, M.-L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-08-19
- Volume
- 94
- Issue
- 17
- Pages
- 9337-9342
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974654770
- Cited by
- 270
- References
- 0
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. https://app.cochat.ai/papers/10.1073/pnas.94.17.9337
- The paper
- Braeuninger, A., Küppers, R., Strickler, J. G., Wacker, H.-H., Rajewsky, K., & Hansmann, M.-L. (1997). Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.17.9337
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