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Cited by 342

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

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Goossens, Tina, Klein, Ulf, Küppers, Ralf·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.5.2463
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Abstract

Human naive and germinal center (GC) B cells were sorted by flow cytometry and rearranged V H region genes were amplified and sequenced from single cells. Whereas no deletions or insertions were found in naive B cells, ≈4% of in-frame and >40% of out-of-frame rearrangements of GC B cells harbored deletions and/or insertions of variable length. The pattern of deletions/insertions and their restriction to mutated V genes strongly suggests that they result from somatic hypermutation. Deletions and insertions account for ≈6% of somatic mutations introduced into rearranged V H region genes of GC B cells. These deletions/insertions seem to be the main cause for the generation of heavy chain disease proteins. Furthermore, it appears that several types of oncogene translocations (like c-myc translocations in Burkitt’s lymphoma) occur as a byproduct of somatic hypermutation within the GC—and not during V(D)J recombination in the bone marrow as previously thought.

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Metadata

Authors
Goossens, T., Klein, U., & Küppers, R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1998-03-03
Volume
95
Issue
5
Pages
2463-2468
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.5.2463
OpenAlex
W1998675277
Cited by
342
References
47
FWCI
10.47
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. https://app.cochat.ai/papers/10.1073/pnas.95.5.2463
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Goossens, T., Klein, U., & Küppers, R. (1998). Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.5.2463

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.