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Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4
Open accessAbstract
We describe the identification of Neuregulin-3 (NRG3), a novel protein that is structurally related to the neuregulins (NRG1). The NRG1/neuregulins are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. The biological effects of NRG1 are mediated by receptor tyrosine kinases ErbB2, ErbB3, and ErbB4. However, genetic studies have suggested that the activity of ErbB4 may also be regulated in the central nervous system by a ligand distinct from NRG1. NRG3 is predicted to contain an extracellular domain with an epidermal growth factor (EGF) motif, a transmembrane domain, and a large cytoplasmic domain. We show that the EGF-like domain of NRG3 binds to the extracellular domain of ErbB4 in vitro . Moreover, NRG3 binds to ErbB4 expressed on cells and stimulates tyrosine phosphorylation of this receptor. The expression of NRG3 is highly restricted to the developing and adult nervous system. These data suggest that NRG3 is a novel, neural-enriched ligand for ErbB4.
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A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF
Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., & Klagsbrun, M. (1991) · Science · doi:10.1126/science.1840698 · Cited by 1,127
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Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
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Epidermal growth factor receptor (EGFR) signaling in cancer
Normanno, N., De Luca, A., Bianco, C., Strizzi, L., Mancino, M., Maiello, M. R., Carotenuto, A., De Feo, G., Caponigro, F., & Salomon, D. S. (2006) · Gene · doi:10.1016/j.gene.2005.10.018 · Cited by 2,038
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
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Neuregulins: functions, forms, and signaling strategies
Falls, D. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00102-7 · Cited by 1,071
Signals of recent positive selection in a worldwide sample of human populations
Pickrell, J. K., Coop, G., Novembre, J., Kudaravalli, S., Li, J. Z., Absher, D., Srinivasan, B. S., Barsh, G. S., Myers, R. M., Feldman, M. W., et al. (2009) · Genome Research · doi:10.1101/gr.087577.108 · Cited by 717
Metadata
- Authors
- Zhang, D., Sliwkowski, M. X., Mark, M., Frantz, G., Akita, R., Sun, Y., Hillan, K., Crowley, C., Brush, J., & Godowski, P. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-09-02
- Volume
- 94
- Issue
- 18
- Pages
- 9562-9567
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2157981718
- Cited by
- 383
- References
- 1
- FWCI
- 13.32
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4. https://app.cochat.ai/papers/10.1073/pnas.94.18.9562
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- Zhang, D., Sliwkowski, M. X., Mark, M., Frantz, G., Akita, R., Sun, Y., Hillan, K., Crowley, C., Brush, J., & Godowski, P. J. (1997). Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.18.9562
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