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Conformational fluctuations in single DNA molecules
Open accessAbstract
Measurement of fluorescent lifetimes of dye-tagged DNA molecules reveal the existence of different conformations. Conformational fluctuations observed by fluorescence correlation spectroscopy give rise to a relaxation behavior that is described by “stretched” exponentials and indicates the presence of a distribution of transition rates between two conformations. Whether this is an inhomogeneous distribution, where each molecule contributes with its own reaction rate to the overall distribution, or a homogeneous distribution, where the reaction rate of each molecule is time-dependent, is not yet known. We used a tetramethylrhodamine-linked 217-bp DNA oligonucleotide as a probe for conformational fluctuations. Fluorescence fluctuations from single DNA molecules attached to a streptavidin-coated surface directly show the transitions between two conformational states. The conformational fluctuations typical for single molecules are similar to those seen in single ion channels in cell membranes.
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An Algorithm for Least-Squares Estimation of Nonlinear Parameters
Marquardt, D. W. (1963) · Journal of the Society for Industrial and Applied Mathematics · doi:10.1137/0111030 · Cited by 30,728
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Kask, P., Palo, K., Ullmann, D., & Gall, K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13756 · Cited by 455
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Heilemann, M., Margeat, E., Kasper, R., Sauer, M., & Tinnefeld, P. (2005) · Journal of the American Chemical Society · doi:10.1021/ja044686x · Cited by 406
Metadata
- Authors
- Wennmalm, S., Edman, L., & Rigler, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-09-30
- Volume
- 94
- Issue
- 20
- Pages
- 10641-10646
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097604852
- Cited by
- 183
- References
- 1
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Wennmalm, S., Edman, L., & Rigler, R. (1997). Conformational fluctuations in single DNA molecules. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.20.10641
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