The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
Open accessAbstract
Recent advances in our understanding of the immune response are allowing for the logical design of new approaches to cancer immunization. One area of interest is the development of new immune adjuvants. Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can induce production of a wide variety of cytokines and activate B cells, monocytes, dendritic cells, and NK cells. Using the 38C13 B cell lymphoma model, we assessed whether CpG ODN can function as immune adjuvants in tumor antigen immunization. The idiotype served as the tumor antigen. Select CpG ODN were as effective as complete Freund’s adjuvant at inducing an antigen-specific antibody response but were associated with less toxicity. These CpG ODN induced a higher titer of antigen-specific IgG2a than did complete Freund’s adjuvant, suggesting an enhanced TH1 response. Mice immunized with CpG ODN as an adjuvant were protected from tumor challenge to a degree similar to that seen in mice immunized with complete Freund’s adjuvant. We conclude that CpG ODN are effective as immune adjuvants and are attractive as part of a tumor immunization strategy.
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Cites
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
Self-citationRegulation of antibody isotype secretion by subsets of antigen-specific helper T cells
Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933
Cited by
Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells
Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605
Self-citationLevin, A. A. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00140-2 · Cited by 438
Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications
Zhu, G., Hu, R., Zhao, Z., Chen, Z., Zhang, X., & Tan, W. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406115e · Cited by 429
Vicari, A. P., Chiodoni, C., Vaure, C., Aït-Yahia, S., Dercamp, C., Matsos, F., Reynard, O., Taverne, C., Merle, P., Colombo, M. P., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020732 · Cited by 343
Bacterial CpG DNA Activates Immune Cells to Signal Infectious Danger
Wagner, H. (1999) · Advances in Immunology · doi:10.1016/s0065-2776(08)60790-7 · Cited by 314
Metadata
- Authors
- Weiner, G. J., Liu, H.-M., Wooldridge, J. E., Dahle, C. E., & Krieg, A. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-09-30
- Volume
- 94
- Issue
- 20
- Pages
- 10833-10837
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084341407
- Cited by
- 519
- References
- 2
- FWCI
- 16.11
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. https://app.cochat.ai/papers/10.1073/pnas.94.20.10833
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- Weiner, G. J., Liu, H.-M., Wooldridge, J. E., Dahle, C. E., & Krieg, A. M. (1997). Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.20.10833
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