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Glu-tRNA Gln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation
Open accessAbstract
The three genes, gatC , gatA , and gatB , which constitute the transcriptional unit of the Bacillus subtilis glutamyl-tRNA Gln amidotransferase have been cloned. Expression of this transcriptional unit results in the production of a heterotrimeric protein that has been purified to homogeneity. The enzyme furnishes a means for formation of correctly charged Gln-tRNA Gln through the transamidation of misacylated Glu-tRNA Gln , functionally replacing the lack of glutaminyl-tRNA synthetase activity in Gram-positive eubacteria, cyanobacteria, Archaea, and organelles. Disruption of this operon is lethal. This demonstrates that transamidation is the only pathway to Gln-tRNA Gln in B. subtilis and that glutamyl-tRNA Gln amidotransferase is a novel and essential component of the translational apparatus.
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Cited by
Alm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., et al. (1999) · Nature · doi:10.1038/16495 · Cited by 1,893
Horizontal gene transfer in prokaryotes: Quantification and classification
Koonin, E. V., Makarova, K. S., & Aravind, L. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.709 · Cited by 1,126
Aminoacyl-tRNA Synthetases, the Genetic Code, and the Evolutionary Process
Woese, C. R., Olsen, G. J., Ibba, M., & Söll, D. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.202-236.2000 · Cited by 706
Structure and function of fatty acid amide hydrolase
McKinney, M. K., & Cravatt, B. F. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133450 · Cited by 680
Determination of the Core of a Minimal Bacterial Gene Set
Gil, R., Silva, F. J., Peretó, J., & Moya, A. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.518-537.2004 · Cited by 573
Metadata
- Authors
- Curnow, A. W., Hong, K.-W., Yuan, R., Kim, S.-I., Martins, O., Winkler, W., Henkin, T. M., & Söll, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-10-28
- Volume
- 94
- Issue
- 22
- Pages
- 11819-11826
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2147302373
- Cited by
- 313
- References
- 0
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Glu-tRNA Gln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. https://app.cochat.ai/papers/10.1073/pnas.94.22.11819
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- Curnow, A. W., Hong, K.-W., Yuan, R., Kim, S.-I., Martins, O., Winkler, W., Henkin, T. M., & Söll, D. (1997). Glu-tRNA Gln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.22.11819
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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