The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport
Open accessAbstract
Fast axonal transport is characterized by the bidirectional, microtubule-based movement of membranous organelles. Cytoplasmic dynein is necessary but not sufficient for retrograde transport directed from the synapse to the cell body. Dynactin is a heteromultimeric protein complex, enriched in neurons, that binds to both microtubules and cytoplasmic dynein. To determine whether dynactin is required for retrograde axonal transport, we examined the effects of anti-dynactin antibodies on organelle transport in extruded axoplasm. Treatment of axoplasm with antibodies to the p150 Glued subunit of dynactin resulted in a significant decrease in the velocity of microtubule-based organelle transport, with many organelles bound along microtubules. We examined the molecular mechanism of the observed inhibition of motility, and we demonstrated that antibodies to p150 Glued disrupted the binding of cytoplasmic dynein to dynactin and also inhibited the association of cytoplasmic dynein with organelles. In contrast, the anti-p150 Glued antibodies had no effect on the binding of dynactin to microtubules nor on cytoplasmic dynein-driven microtubule gliding. These results indicate that the interaction between cytoplasmic dynein and the dynactin complex is required for the axonal transport of membrane-bound vesicles and support the hypothesis that dynactin may function as a link between the organelle, the microtubule, and cytoplasmic dynein during vesicle transport.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Walker, R. A., O'Brien, E. T., Pryer, N. K., Soboeiro, M. F., Voter, W. A., Erickson, H. P., & Salmon, E. D. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1437 · Cited by 980
Opposing motor activities are required for the organization of the mammalian mitotic spindle pole.
Gaglio, T., Saredi, A., Bingham, J. B., Hasbani, M. J., Gill, S. R., Schroer, T. A., & Compton, D. A. (1996) · The Journal of cell biology · doi:10.1083/jcb.135.2.399 · Cited by 290
Research works printed but not linked: 32
- 10.1083/jcb.100.5.1736 · DOI · Paper page
- 10.1016/0092-8674(85)90160-6 · DOI · Paper page
- 10.1016/0092-8674(85)90159-X · DOI · Paper page
- 10.1016/0168-0102(93)90099-C · DOI
- 10.1073/pnas.86.5.1548 · DOI · Paper page
- 10.1016/0092-8674(89)90627-2 · DOI · Paper page
- 10.1083/jcb.111.3.1027 · DOI · Paper page
- 10.1146/annurev.ph.58.030196.003535 · DOI
- 10.1083/jcb.126.2.403 · DOI · Paper page
- 10.1083/jcb.135.6.1815 · DOI · Paper page
- 10.1038/351579a0 · DOI · Paper page
- 10.1083/jcb.115.6.1639 · DOI · Paper page
- 10.1016/S0021-9258(18)82472-3 · DOI
- 10.1038/359244a0 · DOI · Paper page
- 10.1083/jcb.132.4.617 · DOI · Paper page
- 10.1091/mbc.7.8.1167 · DOI
- 10.1074/jbc.270.48.28806 · DOI · Paper page
- 10.1083/jcb.131.6.1507 · DOI · Paper page
- 10.1073/pnas.92.5.1634 · DOI · Paper page
- E Harlow, D Lane Antibodies: A Laboratory Manual (Cold Spring Harbor Lab. Press, Cold Spring Harbor, NY), pp. 628–629 (1988).
- 10.1074/jbc.271.2.1153 · DOI
- D G Weiss, G M Langford, D Seitz-Tutter, W Maile Acta Histochem Supp 41, 81–105 (1991).
- 10.1038/356722a0 · DOI · Paper page
- 10.1002/cm.970060210 · DOI
- 10.1083/jcb.99.2.445 · DOI
- 10.1038/315245a0 · DOI
- 10.1083/jcb.133.3.585 · DOI · Paper page
- R A Walker, N R Gliksman, E D Salmon Optical Microscopy for Biology, eds B Herman, K Jacobson, J Lemasters (Wiley, New York), pp. 395–407 (1990).
- 10.1073/pnas.87.3.1061 · DOI · Paper page
- 10.1126/science.271.5255.1539 · DOI · Paper page
- 10.1002/cm.970280304 · DOI
- Steffen W. Karki S. Vaughan K. T. Vallee R. B. Holzbaur E. L. F. Weiss D. G. & Kuznetsov S. A. (1997) Mol. Biol. Cell in press.
Cited by
Disruption of two novel genes by a translocation co-segregating with schizophrenia
Millar, J. K. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1415 · Cited by 1,254
The axonal transport of mitochondria
Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771
Misko, A., Jiang, S., Wegorzewska, I., Milbrandt, J., & Baloh, R. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6248-09.2010 · Cited by 641
Bidirectional transport along microtubules
Welte, M. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.045 · Cited by 577
Axonal transport and neurodegenerative disease
Chevalier-Larsen, E., & Holzbaur, E. L. F. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.04.002 · Cited by 438
Self-citation
Metadata
- Authors
- Waterman-Storer, C. M., Karki, S. B., Kuznetsov, S. A., Tabb, J. S., Weiss, D. G., Langford, G. M., & Holzbaur, E. L. F.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-10-28
- Volume
- 94
- Issue
- 22
- Pages
- 12180-12185
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072596507
- Cited by
- 257
- References
- 3
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. https://app.cochat.ai/papers/10.1073/pnas.94.22.12180
- The paper
- Waterman-Storer, C. M., Karki, S. B., Kuznetsov, S. A., Tabb, J. S., Weiss, D. G., Langford, G. M., & Holzbaur, E. L. F. (1997). The interaction between cytoplasmic dynein and dynactin is required for fast axonal transport. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.22.12180
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
