The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation
Open accessAbstract
Modern functional neuroimaging methods, such as positron-emission tomography (PET), optical imaging of intrinsic signals, and functional MRI (fMRI) utilize activity-dependent hemodynamic changes to obtain indirect maps of the evoked electrical activity in the brain. Whereas PET and flow-sensitive MRI map cerebral blood flow (CBF) changes, optical imaging and blood oxygenation level-dependent MRI map areas with changes in the concentration of deoxygenated hemoglobin (HbR). However, the relationship between CBF and HbR during functional activation has never been tested experimentally. Therefore, we investigated this relationship by using imaging spectroscopy and laser-Doppler flowmetry techniques, simultaneously, in the visual cortex of anesthetized cats during sensory stimulation. We found that the earliest microcirculatory change was indeed an increase in HbR, whereas the CBF increase lagged by more than a second after the increase in HbR. The increased HbR was accompanied by a simultaneous increase in total hemoglobin concentration (Hbt), presumably reflecting an early blood volume increase. We found that the CBF changes lagged after Hbt changes by 1 to 2 sec throughout the response. These results support the notion of active neurovascular regulation of blood volume in the capillary bed and the existence of a delayed, passive process of capillary filling.
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Functional mapping of the human visual cortex by magnetic resonance imaging
Belliveau, J. W., Kennedy, D. N., McKinstry, R. C., Buchbinder, B. R., Weisskoff, R. M., Cohen, M. S., Vevea, J. M., Brady, T. J., & Rosen, B. R. (1991) · Science · doi:10.1126/science.1948051 · Cited by 1,883
Cited by
The neural basis of functional brain imaging signals
Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957
Cui, X., Bryant, D. M., & Reiss, A. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.003 · Cited by 807
“, 2011), including physiological mechanisms of the BOLD response (Emir et al., 2008; Hoge et al., 2005; Huppert et al., 2006, 2007, 2009; Kleinschmidt et al., 1996; Malonek et al., 1997; Schroeter et al., 2006; Toronov et al., 2003), non-invasive brain-computer interfaces (Coyle et al.”
Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Ayata, C., & Lauritzen, M. (2015) · Physiological Reviews · doi:10.1152/physrev.00027.2014 · Cited by 555
Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513
Metadata
- Authors
- Malonek, D., Dirnagl, U., Lindauer, U., Yamada, K., Kanno, I., & Grinvald, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14826-14831
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2150617546
- Cited by
- 443
- References
- 2
- FWCI
- 18.14
- Type
- journal article
- Language
- en
- Open access
- green
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- Malonek, D., Dirnagl, U., Lindauer, U., Yamada, K., Kanno, I., & Grinvald, A. (1997). Vascular imprints of neuronal activity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.26.14826
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