The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
Open accessAbstract
Neuronal nitric oxide synthase (nNOS) generates NO in neurons, and heme-oxygenase-2 (HO-2) synthesizes carbon monoxide (CO). We have evaluated the roles of NO and CO in intestinal neurotransmission using mice with targeted deletions of nNOS or HO-2. Immunohistochemical analysis demonstrated colocalization of nNOS and HO-2 in myenteric ganglia. Nonadrenergic noncholinergic relaxation and cyclic guanosine 3′,5′ monophosphate elevations evoked by electrical field stimulation were diminished markedly in both nNOS Δ / Δ and HO-2 Δ / Δ mice. In wild-type mice, NOS inhibitors and HO inhibitors partially inhibited nonadrenergic noncholinergic relaxation. In nNOS Δ / Δ animals, NOS inhibitors selectively lost their efficacy, and HO inhibitors were inactive in HO-2 Δ / Δ animals.
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Cites
Stone, J. R., & Marletta, M. A. (1994) · Biochemistry · doi:10.1021/bi00184a036 · Cited by 647
Cited by
Guanylate cyclase and the ⋅NO/cGMP signaling pathway
Denninger, J. W., & Marletta, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00024-9 · Cited by 1,040
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
H2S signalling through protein sulfhydration and beyond
Paul, B. D., & Snyder, S. H. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3391 · Cited by 853
Self-citationDoré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699
Self-citationHeme Oxygenase: Recent Advances in Understanding Its Regulation and Role
Elbirt, K. K., & Bonkovsky, H. L. (1999) · Proceedings of the Association of American Physicians · doi:10.1111/paa.1999.111.5.438 · Cited by 308
Metadata
- Authors
- Zakhary, R., Poss, K. D., Jaffrey, S. R., Ferris, C. D., Tonegawa, S., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14848-14853
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978765308
- Cited by
- 236
- References
- 1
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Zakhary, R., Poss, K. D., Jaffrey, S. R., Ferris, C. D., Tonegawa, S., & Snyder, S. H. (1997). Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.26.14848
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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