Cited by 1,040Hemoglobin structure and functionNitric Oxide and Endothelin EffectsReceptor Mechanisms and Signaling

Guanylate cyclase and the ⋅NO/cGMP signaling pathway

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Denninger, John W, Marletta, Michael A·1999·Biochimica et Biophysica Acta (BBA) - Bioenergetics

Abstract

Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of important physiological processes, including smooth muscle relaxation and neurotransmission. Soluble guanylate cyclase (sGC), a heterodimeric enzyme that converts guanosine triphosphate to cyclic guanosine monophosphate, is a critical component of this signaling pathway. sGC is a hemoprotein; it is through the specific interaction of NO with the sGC heme that sGC is activated. Over the last decade, much has been learned about the unique heme environment of sGC and its interaction with ligands like NO and carbon monoxide. This review will focus on the role of sGC in signaling, its relationship to the other nucleotide cyclases, and on what is known about sGC genetics, heme environment and catalysis. The latest understanding in regard to sGC will be incorporated to build a model of sGC structure, activation, catalytic mechanism and deactivation.

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Crossref · 10.1016/s0005-2728(99)00024-9

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Authors
Denninger, J. W., & Marletta, M. A.
Affiliations
University of Michigan (US)
Venue
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher
Elsevier BV
Published
1999-05
Volume
1411
Issue
2-3
Pages
334-350
ISSN
0005-2728 (ISSN-L)
OpenAlex
W2071293996
Cited by
1,040
References
123
Citations by year
2026: 13 · 2025: 30 · 2024: 29 · 2023: 41 · 2022: 38 · 2021: 29 · 2020: 35 · 2019: 41 · 2018: 49 · 2017: 35 · 2016: 41 · 2015: 30 · 2014: 35 · 2013: 29 · 2012: 33
FWCI
3.50
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
soluble guanylate cyclase, nitric oxide signaling, cGMP signaling, heme proteins, carbon monoxide, smooth muscle relaxation, neurotransmission, enzyme mechanism, enzyme inactivation
MeSH terms
Animals, Catalysis, Cell Line, Enzyme Activation, Free Radicals, Cyclic GMP, Guanylate Cyclase, Humans, Models, Chemical, Nitric Oxide, Structure-Activity Relationship, Signal Transduction, Gene Expression, Nitric Oxide Synthase

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