The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
Open accessAbstract
Impaired insulin secretion is a characteristic of non-insulin-dependent diabetes mellitus (NIDDM). One possible therapeutic agent for NIDDM is the insulinotropic hormone glucagon-like peptide 1 (GLP-1). GLP-1 stimulates insulin secretion through several mechanisms including activation of protein kinase A (PKA). We now demonstrate that the subcellular targeting of PKA through association with A - k inase- a nchoring p roteins (AKAPs) facilitates GLP-1-mediated insulin secretion. Disruption of PKA anchoring by the introduction of anchoring inhibitor peptides or expression of soluble AKAP fragments blocks GLP-1 action in primary islets and cAMP-responsive insulin secretion in clonal beta cells (RINm5F). Displacement of PKA also prevented cAMP-mediated elevation of intracellular calcium suggesting that localized PKA phosphorylation events augment calcium flux.
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Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., & Habener, J. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3434 · Cited by 903
Rosenmund, C., Carr, D. W., Bergeson, S. E., Nilaver, G., Scott, J. D., & Westbrook, G. L. (1994) · Nature · doi:10.1038/368853a0 · Cited by 371
Self-citationLu, M., Wheeler, M. B., Leng, X. H., & Boyd, A. E. (1993) · Endocrinology · doi:10.1210/endo.132.1.8380389 · Cited by 151
Cullinan, C. A., Brady, E. J., Saperstein, R., & Leibowitz, M. D. (1994) · Cell Calcium · doi:10.1016/0143-4160(94)90014-0 · Cited by 29
Cited by
The role of incretins in glucose homeostasis and diabetes treatment
Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824
Meloni, A. R., DeYoung, M. B., Lowe, C., & Parkes, D. G. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01663.x · Cited by 407
Dynamics of cAMP-Dependent Protein Kinase
Johnson, D. A., Akamine, P., Radzio-Andzelm, E., Madhusudan, & Taylor, S. S. (2001) · Chemical Reviews · doi:10.1021/cr000226k · Cited by 393
Holz, G. G. (2004) · Diabetes · doi:10.2337/diabetes.53.1.5 · Cited by 391
Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion
Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H., & Seino, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108378200 · Cited by 381
Metadata
- Authors
- Lester, L. B., Langeberg, L. K., & Scott, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-12-23
- Volume
- 94
- Issue
- 26
- Pages
- 14942-14947
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2100755520
- Cited by
- 193
- References
- 4
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Lester, L. B., Langeberg, L. K., & Scott, J. D. (1997). Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.26.14942
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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