The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cytosol-to-membrane redistribution of Bax and Bcl-XLduring apoptosis
Open accessAbstract
Bcl-2, Bcl-X L, and Bax are members of the Bcl-2 family that play key roles in the regulation of apoptosis. These proteins are believed to be membrane bound and their ability to undergo both homodimerization and heterodimerization has been proposed to regulate apoptosis. Herein we report that in murine thymocytes, Bcl-2 is exclusively membrane-bound, whereas Bax is present predominantly in the cytosol and Bcl-X L is present in both soluble and membrane-bound forms. Induction of apoptosis in murine thymocytes by dexamethasone or γ-irradiation shifts the subcellular locations of Bax and Bcl-X L from soluble to membrane-bound forms. A similar shift in the localization of Bax from the cytosol to membranes was observed in HL-60 leukemia cells upon induction of apoptosis by staurosporine. Inhibition of apoptosis with cycloheximide inhibits the movement of Bax and Bcl-X L in thymocytes from the cytosol into membranes induced by dexamethasone treatment. These movements may represent an important step in the pathway by which members of this family regulate apoptosis.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003
Cited by
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The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987
Self-citationThe Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00055-7 · Cited by 1,755
Self-citationMitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Metadata
- Authors
- Hsu, Y.-T., Wolter, K. G., & Youle, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-04-15
- Volume
- 94
- Issue
- 8
- Pages
- 3668-3672
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033873142
- Cited by
- 1,134
- References
- 2
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Hsu, Y.-T., Wolter, K. G., & Youle, R. J. (1997). Cytosol-to-membrane redistribution of Bax and Bcl-XLduring apoptosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.8.3668
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