Mitochondria and cell death: outer membrane permeabilization and beyond

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

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The BCL-2 protein family: opposing activities that mediate cell death

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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Apoptosis: controlled demolition at the cellular level

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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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Endonuclease G is an apoptotic DNase when released from mitochondria

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The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

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Bid, Bax, and Lipids Cooperate to Form Supramolecular Openings in the Outer Mitochondrial Membrane

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

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The BCL-2 Family Reunion

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Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cPreprint

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteinsPreprint

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IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

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Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

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Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

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Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

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Cytosol-to-membrane redistribution of Bax and Bcl-X L during apoptosis

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A Serine Protease, HtrA2, Is Released from the Mitochondria and Interacts with XIAP, Inducing Cell Death

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Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

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Structure of Bax

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

Goldstein, J. C., Waterhouse, N. J., Juin, P. P., Evan, G. I., & Green, D. R. (2000) · Nature Cell Biology · doi:10.1038/35004029 · Cited by 1,073 · see citing works

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

Scorrano, L., Ashiya, M., Buttle, K., Weiler, S., Oakes, S. A., Mannella, C. A., & Korsmeyer, S. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(01)00116-2 · Cited by 1,072 · see citing works

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

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IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

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Inhibition of Bax Channel-Forming Activity by Bcl-2

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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A Unified Model for Apical Caspase Activation

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Cytochrome c release from mitochondria proceeds by a two-step process

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Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis

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Negative regulation of the Apaf-1 apoptosome by Hsp70

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

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Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

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BAX activation is initiated at a novel interaction site

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The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

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Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

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Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

Kazama, H., Ricci, J.-E., Herndon, J. M., Hoppe, G., Green, D. R., & Ferguson, T. A. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.013 · Cited by 627 · see citing works

Role of Bax and Bak in mitochondrial morphogenesis

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Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain

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Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

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Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

Lovell, J. F., Billen, L. P., Bindner, S., Shamas‐Din, A., Fradin, C., Leber, B. F., & Andrews, D. W. (2008) · Cell · doi:10.1016/j.cell.2008.11.010 · Cited by 565 · see citing works

Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90

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Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

Li, Z., Jo, J., Jia, J., Lo, S., Whitcomb, D. J., Jiao, S., Cho, K., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.03.053 · Cited by 533 · see citing works

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.Preprint

Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P. Y. B., Berry, D., Tamblyn, L., Shehabeldin, A., Migon, E., et al. (2003) · Genes & Development · doi:10.1101/gad.1063703 · Cited by 517 · see citing works

GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

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Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., & Williams, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80849-1 · Cited by 509 · see citing works

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

Ricci, J.-E., Gottlieb, R. A., & Green, D. R. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208089 · Cited by 504 · see citing works

XIAP discriminates between type I and type II FAS-induced apoptosis

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Dissecting p53 tumor suppressor functions in vivo

Schmitt, C. A., Fridman, J. S., Yang, M., Baranov, E., Hoffman, R. M., & Lowe, S. W. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00047-8 · Cited by 481 · see citing works

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

Nechushtan, A., Smith, C. L., Lamensdorf, I., Yoon, S., & Youle, R. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1265 · Cited by 477 · see citing works

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

Allan, L. A., MORRICE, N. A., Brady, S. C., Magee, G. J., Pathak, S., & Clarke, P. R. (2003) · Nature Cell Biology · doi:10.1038/ncb1005 · Cited by 474 · see citing works

Cytochrome C Maintains Mitochondrial Transmembrane Potential and Atp Generation after Outer Mitochondrial Membrane Permeabilization during the Apoptotic Process

Waterhouse, N. J., Goldstein, J. C., von Ahsen, O., Schüler, M., Newmeyer, D. D., & Green, D. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.319 · Cited by 452 · see citing works

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak‐mediated permeabilization

Arnoult, D., Gaume, B. R., Karbowski, M., Sharpe, J. C., Cecconi, F., & Youle, R. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg423 · Cited by 451 · see citing works

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

Saito, M. L., Korsmeyer, S. J., & Schlesinger, P. H. (2000) · Nature Cell Biology · doi:10.1038/35019596 · Cited by 445 · see citing works

Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria

Polster, B. M., Basáñez, G., Etxebarria, A., Hardwick, J. M., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413269200 · Cited by 438 · see citing works

Structural Basis of Pore Formation by the Bacterial Toxin Pneumolysin

Tilley, S. J., Orlova, E. V., Gilbert, R. J. C., Andrew, P. W., & Saibil, H. R. (2005) · Cell · doi:10.1016/j.cell.2005.02.033 · Cited by 421 · see citing works

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

Vaughn, A. E., & Deshmukh, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1807 · Cited by 408 · see citing works

Cytochrome c activation of CPP32‐like proteolysis plays a critical role in a Xenopus cell‐free apoptosis system

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Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway

Jiang, X., Kim, H.-E., Shu, H., Zhao, Y., Zhang, H., Kofron, J. L., Donnelly, J. B., Burns, D., Ng, S., Rosenberg, S. H., et al. (2003) · Science · doi:10.1126/science.1076807 · Cited by 378 · see citing works

Caspase-independent cell death: leaving the set without the final cut

Tait, S. W. G., & Green, D. R. (2008) · Oncogene · doi:10.1038/onc.2008.311 · Cited by 353 · see citing works

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

Dewson, G., Kratina, T., Sim, H. W., Puthalakath, H., Adams, J. M., Colman, P. M., & Kluck, R. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.005 · Cited by 348 · see citing works

Formation of apoptosome is initiated by cytochrome c -induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1

Kim, H.-E., Du, F., Fang, M., & Wang, X. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507900102 · Cited by 344 · see citing works

Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis

Germain, M., Mathai, J. P., McBride, H. M., & Shore, G. C. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600592 · Cited by 337 · see citing works

Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

Jagasia, R., Grote, P., Westermann, B., & Conradt, B. (2005) · Nature · doi:10.1038/nature03316 · Cited by 319 · see citing works

The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event

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Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

Rathmell, J. C., Lindsten, T., Zong, W., Cinalli, R. M., & Thompson, C. B. (2002) · Nature Immunology · doi:10.1038/ni834 · Cited by 297 · see citing works

The Apoptosome Activates Caspase-9 by Dimerization

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Opa1-Mediated Cristae Opening Is Bax/Bak and BH3 Dependent, Required for Apoptosis, and Independent of Bak Oligomerization

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