Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
Open accessAbstract
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety of cytokines, including the interleukin 6 family of cytokines, leptin, granulocyte colony-stimulating factor, and epidermal growth factor. To address the biological function of Stat3, we generated mice deficient in Stat3 by gene targeting. No viable Stat3-deficient mice could be obtained from heterozygote intercross. Analysis of embryos at several gestation times revealed that Stat3-deficient embryos showed a rapid degeneration between embryonic days 6.5 and 7.5, although they developed into the egg cylinder stage until embryonic day 6.0. These results demonstrate that Stat3 is essential for the early development of mouse embryos.
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Disruption of the STAT3 gene during embryonic stages causes lethality.
“Because STAT3 deletion leads to embryonic lethality (12”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [12]
Among the knock-out mouse models now available, only STAT3 plays an essential role in early embryonic development.
“From the knock-out mouse models now available, only STAT3 plays an essential role in early embryonic development (12”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [12]
All of the other STAT knock-outs have relatively mild phenotypes correlated with rather specific defects in response to certain cytokines or growth factors.
“All of the other STAT knock-outs have relatively mild phenotypes correlated with rather specific defects in response to certain cytokines or growth factors (12”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [12]
STAT3 knockout in all cells causes embryonic lethality at 7 days.
“Embryonic lethal at 7 days”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Takeda et al., 1997
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References 24 · Cited by 1,323
- Authors
- Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S.
- Affiliations
- Hyogo Medical University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1997-04-15
- Volume
- 94
- Issue
- 8
- Pages
- 3801-3804
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC20521
- OpenAlex
- W2035134361
- Cited by
- 1,323
- References
- 24
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 32 · 2023: 27 · 2022: 21 · 2021: 43 · 2020: 47 · 2019: 35 · 2018: 39 · 2017: 51 · 2016: 44 · 2015: 40 · 2014: 49 · 2013: 59 · 2012: 61
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- STAT3, signal transducer and activator of transcription, gene targeting, embryonic lethality, early embryonic development, cytokine signaling, mouse embryo, knockout mice
- MeSH terms
- Animals, DNA-Binding Proteins, Female, Embryonic and Fetal Development, Pregnancy, Signal Transduction, Trans-Activators, Mice, Knockout, STAT3 Transcription Factor, Mice
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