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Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells
Open accessAbstract
We have recently identified α-galactosylceramide (α-GalCer) as a specific ligand for an invariant Vα14/Vβ8.2 T cell receptor exclusively expressed on the majority of Vα14 NKT cells, a novel subset of lymphocytes. Here, we report that α-GalCer selectively activates Vα14 NKT cells resulting in prevention of tumor metastasis. The effector mechanisms of the ligand-activated Vα14 NKT cells seem to be mediated by natural killer (NK)-like nonspecific cytotoxicity. Indeed, the cytotoxic index obtained by α-GalCer-activated Vα14 NKT cells was reduced by the addition of cold target tumor cells or by treatment with concanamycin A, which inhibits activation and secretion of perforin, but not by mAbs against molecules involved in the NKT cell recognition and conventional cytotoxicity, such as CD1d, Vβ8, NK1.1, Ly49C, Fas, or Fas ligand. These results suggest that the ligand-activated Vα14 NKT cells kill tumor cells directly through a CD1d/Vα14 T cell receptor-independent, NK-like mechanism.
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Citations
Cited by
Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923
Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4647 · Cited by 854
Self-citationMetelitsa, L. S., Naidenko, O. V., Kant, A., Wu, H.-W., Loza, M. J., Perussia, B., Kronenberg, M., & Seeger, R. C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3114 · Cited by 355
Burdin, N., Brossay, L., & Kronenberg, M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06<2014::aid-immu2014>3.0.co;2-g · Cited by 301
Lynch, L., O'Shea, D., Winter, D. C., Geoghegan, J., Doherty, D. G., & O'Farrelly, C. (2009) · European Journal of Immunology · doi:10.1002/eji.200939349 · Cited by 257
Metadata
- Authors
- Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Sato, H., Kondo, E., Harada, M., Koseki, H., Nakayama, T., Tanaka, Y., & Taniguchi, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5690-5693
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048724356
- Cited by
- 476
- References
- 0
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Sato, H., Kondo, E., Harada, M., Koseki, H., Nakayama, T., Tanaka, Y., & Taniguchi, M. (1998). Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14 NKT cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.10.5690
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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