The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells
Abstract
α-Galactosylceramide (α-GalCer) is a glycolipid with potent antitumor properties that binds to CD1d molecules and activates mouse Vα14 and human Vα24 NKT cells. Surprisingly, we found that, as early as 90 min after α-GalCer injection in vivo, NK cells also displayed considerable signs of activation, including IFN-γ production and CD69 induction. NK activation was not observed in RAG- or CD1-deficient mice, and it was decreased by pretreatment with anti-IFN-γ Abs, suggesting that, despite its rapid induction, it was a secondary event that depended on IFN-γ release by NKT cells. At later time points, B cells and CD8 T cells also began to express CD69. These findings identify a high-speed communication network between the innate and adaptive immune systems in vivo that is initiated upon NKT cell activation. They also suggest that the antitumor effects of α-GalCer result from the sequential recruitment of distinct innate and adaptive effector lymphocytes.
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Citations
Cites
CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
Kawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Motoki, K., Ueno, H., Nakagawa, R., Sato, H., Kondo, E., et al. (1997) · Science · doi:10.1126/science.278.5343.1626 · Cited by 2,400
Self-citationNATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines
Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar-Mather, T. P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.189 · Cited by 2,113
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
Bendelac, A., Rivera, M. N., Park, S.-H., & Roark, J. H. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.535 · Cited by 1,326
Self-citationRequirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
Cui, J., Shin, T., Kawano, T., Sato, H., Kondo, E., Toura, I., Kaneko, Y., Koseki, H., Kanno, M., & Taniguchi, M. (1997) · Science · doi:10.1126/science.278.5343.1623 · Cited by 1,237
Lantz, O., & Bendelac, A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.3.1097 · Cited by 1,057
Self-citationYoshimoto, T., & Paul, W. E. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.4.1285 · Cited by 841
Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes
Wilson, S. B., Kent, S. C., Patton, K. T., Orban, T., Jackson, R. A., Exley, M., Porcelli, S., Schatz, D. A., Atkinson, M. A., Balk, S. P., et al. (1998) · Nature · doi:10.1038/34419 · Cited by 646
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., & Kronenberg, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1521 · Cited by 642
Self-citationStructure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice
Morita, M., Motoki, K., Akimoto, K., Natori, T., Sakai, T., Sawa, E., Yamaji, K., Koezuka, Y., Kobayashi, E., & Fukushima, H. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00012a018 · Cited by 599
Self-citationKawano, T., Cui, J., Koezuka, Y., Toura, I., Kaneko, Y., Sato, H., Kondo, E., Harada, M., Koseki, H., Nakayama, T., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5690 · Cited by 476
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Cited by
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
The Liver as an Immunological Organ
Racanelli, V., & Rehermann, B. (2006) · Hepatology · doi:10.1002/hep.21060 · Cited by 1,377
Regulation of NKT cell development by SAP, the protein defective in XLP
Nichols, K. E., Hom, J., Gong, S.-Y., Ganguly, A., Ma, C. S., Cannons, J. L., Tangye, S. G., Schwartzberg, P. L., Koretzky, G. A., & Stein, P. L. (2005) · Nature Medicine · doi:10.1038/nm1189 · Cited by 391
Metelitsa, L. S., Naidenko, O. V., Kant, A., Wu, H.-W., Loza, M. J., Perussia, B., Kronenberg, M., & Seeger, R. C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.6.3114 · Cited by 355
Homotypic Interactions Mediated by Slamf1 and Slamf6 Receptors Control NKT Cell Lineage Development
Griewank, K., Borowski, C., Rietdijk, S., Wang, N., Julien, A., Wei, D. G., Mamchak, A. A., Terhorst, C., & Bendelac, A. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.020 · Cited by 349
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Metadata
- Authors
- Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 163
- Issue
- 9
- Pages
- 4647-4650
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1748261727
- Cited by
- 854
- References
- 25
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., & Bendelac, A. (1999). Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.163.9.4647
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
