The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide
Open accessAbstract
We have discovered that the mosquito Anopheles stephensi, a natural vector of human malaria, limits parasite development with inducible synthesis of nitric oxide (NO). Elevated expression of A. stephensi NO synthase (NOS), which is highly homologous to characterized NOS genes, was detected in the midgut and carcass soon after invasion of the midgut by Plasmodium. Early induction is likely primed by bacterial growth in the blood meal. Later increases in A. stephensi NOS expression and enzyme activity occurred at the beginning of sporozoite release. Circulating levels of nitrite/nitrate, end-products of NO synthesis, were significantly higher in Plasmodium-infected mosquitoes. Dietary provision of the NOS substrate l-arginine reduced Plasmodium infections in A. stephensi. In contrast, dietary provision of a NOS inhibitor significantly increased parasite numbers in infected mosquitoes, confirming that A. stephensi limits Plasmodium development with NO.
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Cites
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523
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Lavine, M. D., & Strand, M. R. (2002) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(02)00092-9 · Cited by 1,632
Nitric oxide and redox mechanisms in the immune response
Wink, D. A., Hines, H. B., Cheng, R. Y. S., Switzer, C. H., Flores-Santana, W., Vitek, M. P., Ridnour, L. A., & Colton, C. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010550 · Cited by 765
Melanogenesis and associated cytotoxic reactions: Applications to insect innate immunity
Nappi, A. J., & Christensen, B. M. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.01.014 · Cited by 675
Dynamic Gut Microbiome across Life History of the Malaria Mosquito Anopheles gambiae in Kenya
Wang, Y., Gilbreath, T. M., Kukutla, P., Yan, G., & Xu, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024767 · Cited by 584
Metadata
- Authors
- Luckhart, S., Vodovotz, Y., Cui, L., & Rosenberg, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-05-12
- Volume
- 95
- Issue
- 10
- Pages
- 5700-5705
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093765409
- Cited by
- 397
- References
- 1
- FWCI
- 21.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Luckhart, S., Vodovotz, Y., Cui, L., & Rosenberg, R. (1998). The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.10.5700
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
