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Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
Open accessAbstract
The PML/SP100 nuclear bodies (NBs) were first described as discrete subnuclear structures containing the SP100 protein. Subsequently, they were shown to contain the PML protein which is part of the oncogenic PML-RARα hybrid produced by the t(15;17) chromosomal translocation characteristic of acute promyelocytic leukemia. Yet, the physiological role of these nuclear bodies remains unknown. Here, we show that SP100 binds to members of the heterochromatin protein 1 (HP1) families of non-histone chromosomal proteins. Further, we demonstrate that a naturally occurring splice variant of SP100, here called SP100-HMG, is a member of the high mobility group-1 (HMG-1) protein family and may thus possess DNA-binding potential. Both HP1 and SP100-HMG concentrate in the PML/SP100 NBs, and overexpression of SP100 leads to enhanced accumulation of endogenous HP1 in these structures. When bound to a promoter, SP100, SP100-HMG and HP1 behave as transcriptional repressors in transfected mammalian cells. These observations present molecular evidence for an association between the PML/SP100 NBs and the chromatin nuclear compartment. They support a model in which the NBs may play a role in certain aspects of chromatin dynamics.
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Cited by
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956
Zhang, R., Poustovoitov, M. V., Ye, X., Santos, H. A., Chen, W., Daganzo, S. M., Erzberger, J. P., Serebriiskii, I. G., Canutescu, A. A., Dunbrack, R. L., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.10.019 · Cited by 699
Nielsen, A. L., Ortiz, J. A., You, J., Oulad‐Abdelghani, M., Khechumian, R., Gansmuller, A., Chambon, P., & Losson, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6385 · Cited by 361
Review: Properties and Assembly Mechanisms of ND10, PML Bodies, or PODs
Maul, G. G., Negorev, D., Bell, P., & Ishov, A. M. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4239 · Cited by 287
Negorev, D., & Maul, G. G. (2001) · Oncogene · doi:10.1038/sj.onc.1204764 · Cited by 258
Metadata
- Authors
- Seeler, J.-S., Marchio, A., Sitterlin, D., Transy, C., & Dejean, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-06-23
- Volume
- 95
- Issue
- 13
- Pages
- 7316-7321
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020034373
- Cited by
- 274
- References
- 0
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. https://app.cochat.ai/papers/10.1073/pnas.95.13.7316
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- Seeler, J.-S., Marchio, A., Sitterlin, D., Transy, C., & Dejean, A. (1998). Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.13.7316
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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