Cited by 899Cancer-related Molecular PathwaysHeat shock proteins researchChromatin Remodeling and Cancer

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

Open access

Kamijo, Takehiko, Weber, Jason D., Zambetti, Gerard, Zindy, Frederique, Roussel, Martine F., Sherr, Charles J.·1998·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.95.14.8292PMC PMC20969

Open this paper in CoChat — free account

Abstract

The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively. Disruption of this locus by deletions or point mutations is a common event in human cancer, perhaps second only to the loss of p53. Using insect cells infected with baculovirus vectors and NIH 3T3 fibroblasts infected with ARF retrovirus, we determined that mouse p19(ARF) can interact directly with p53, as well as with the p53 regulator mdm2. ARF can bind p53-DNA complexes, and it depends upon functional p53 to transcriptionally induce mdm2 and the cyclin-dependent kinase inhibitor p21(Cip1), and to arrest cell proliferation. Binding of p19(ARF) to p53 requires the ARF N-terminal domain (amino acids 1-62) that is necessary and sufficient to induce cell cycle arrest. Overexpression of p19(ARF) in wild type or ARF-null mouse embryo fibroblasts increases the half-life of p53 from 15 to approximately 75 min, correlating with an increased p53-dependent transcriptional response and growth arrest. Surprisingly, when overexpressed at supra-physiologic levels after introduction into ARF-null NIH 3T3 cells or mouse embryo fibroblasts, the p53 protein is handicapped in inducing this checkpoint response. In this setting, reintroduction of p19(ARF) restores p53's ability to induce p21(Cip1) and mdm2, implying that, in addition to stabilizing p53, ARF modulates p53-dependent function through an additional mechanism.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.95.14.8292

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells
Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,327
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Regulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
Self-citation
QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES
Todaro, G. J., & Green, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.299 · Cited by 2,747
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
Shieh, S.-Y., Ikeda, M., Taya, Y., & Prives, C. (1997) · Cell · doi:10.1016/s0092-8674(00)80416-x · Cited by 2,100

Show all 61 references

Research works printed but not linked: 10

M Hollstein, K Rice, M S Greenblatt, T Soussi, R Fuchs, T Sorlie, E Hovig, B Smith-Sorensen, R Montesano, C C Harris Nucleic Acids Res 22, 3551–3555 (1994).
D Duro, O Bernard, V Della Valle, R Berger, C-J Larsen Oncogene 11, 21–29 (1995).
L Mao, A Merlo, G Bedi, G I Shapiro, C D Edwards, B J Rollins, D Sidransky Cancer Res 55, 2995–2997 (1995).
S Stone, P Jiang, P Dayananth, S V Tavtigian, H Katcher, D Parry, G Peters, A Kamb Cancer Res 55, 2988–2994 (1995).
10.1128/mcb.13.7.4107-4114.1993 · DOI
P W Hinds, C A Finlay, R S Quartin, S J Baker, E R Fearon, B Vogelstein, A J Levine Cell Growth Diff 1, 571–580 (1990).
10.1128/mcb.7.8.2745-2752.1987 · DOI
10.1126/science.256.5058.827 · DOI
10.1128/mcb.2.9.1044-1051.1982 · DOI
G Shaulsky, N Goldfinger, M S Tosky, A J Levine, V Rotter Oncogene 6, 2055–2065 (1991).

Sorted by citations

Items 701–800 of 896

Time varying causal network reconstruction of a mouse cell cycle
Masnadi-Shirazi, M., Maurya, M. R., Pao, G. M., Ke, E., Verma, I. M., & Subramaniam, S. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2895-1 · Cited by 5
Therapeutic considerations for Mdm2: not just a one trick pony
Lehman, J. A., Eitel, J. A., Batuello, C. N., & Mayo, L. D. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.11.1309 · Cited by 6
Genetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection
Li, J., Tang, Y., Huang, L., Yu, Q., Hu, G., & Yuan, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158613 · Cited by 5
p53 Tumor Suppressor Protein
Ashcroft, M. A., & Vousden, K. H. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-230-2_7 · Cited by 5
Protein Transduction Domain-Mediated Delivery of Anticancer Proteins
Harada, H., & Hiraoka, M. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0131-6_10 · Cited by 4
Multi-scale modeling of cell survival and death mediated by the p53 network: a systems pharmacology framework
Wang, Y., Guo, Z., Chen, X., Zhang, W., Lü, A., & Wang, Y. (2015) · Molecular BioSystems · doi:10.1039/c5mb00304k · Cited by 4
Inhibiteurs des kinases dépendantes des cyclines et sénescence réplicative
Gerland, L., Ffrench, M., & Magaud, J. (2001) · Pathologie Biologie · doi:10.1016/s0369-8114(01)00249-8 · Cited by 4
UV-radiation as a Risk Factor for Non-melanoma Skin Cancer. Genetic Determinants of Carcinogenesis
Жилова, М. Б., & Butareva, M. M. (2018) · Annals of the Russian academy of medical sciences · doi:10.15690/vramn941 · Cited by 4
Cell Cycle Checkpoints and Senescence
Wadhwa, R., Kaul, Z., & Kaul, S. C. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-26239-0_9 · Cited by 4
Control of the Cell Cycle
Malumbres, M. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-2865-7.00004-7 · Cited by 5
Melanoma Pathogenesis
Lo, J. A., & Fisher, D. E. (2014) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4939-2143-0_2 · Cited by 4
Signaling Cascades Driving the Malignant Phenotype of Glioma Cells
Nakada, M., Kita, D., Furuta, T., Watanabe, T., Hayashi, Y., & Hamada, J. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1431-5_3 · Cited by 4
Inhibition of T-Cell Acute Lymphoblastic Leukemia Proliferation In Vivo by Re-expression of the p16INK4a Tumor Suppressor Gene
Schoppmeyer, K., Norris, P. S., & Haas, M. (1999) · Neoplasia · doi:10.1038/sj.neo.7900021 · Cited by 4
Estimation of the mehylation status of the promoter region of the cell cycle control gene P14ARF in placental tissues of spontaneous abortions with chromosomal mosaicism
Кашеварова, А. А., Tolmacheva, E. N., Sukhanova, N. N., Sazhenova, E. A., & Лебедев, И. Н. (2009) · Russian Journal of Genetics · doi:10.1134/s1022795409060155 · Cited by 4
Adenovirus infection and cytotoxicity of primary mantle cell lymphoma cells
Medina, D. J., Sheay, W., Osman, M., Goodell, L. A., Martin, J., Rabson, A. B., & STRAIR, R. K. (2005) · Experimental Hematology · doi:10.1016/j.exphem.2005.07.009 · Cited by 4
Early diagnosis of melanoma: what do we know?
Yee, E., Hoffman, R. M., & Berwick, M. (2007) · Cited by 4
Novel surrogate end-point biomarker to evaluate agents for use in the chemoprevention of reactive oxygen species-associated cancer
Hiroyasu, M., Ozeki, M., Miyagawa‐Hayashino, A., Fujiwara, Y., Hiai, H., & Toyokuni, S. (2002) · Redox Report · doi:10.1179/135100002125000938 · Cited by 4
Redox Control of Carcinogenesis and Tumor Biology
Toyokuni, S. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604773934233 · Cited by 4
Conformational Stability of the N-Terminal Region of MDM2
Rizzuti, B., Abián, O., Velázquez‐Campoy, A., & Neira, J. L. (2023) · Molecules · doi:10.3390/molecules28227578 · Cited by 3
Epstein–Barr Virus and Burkitt’s Lymphoma
Banerjee, S., Jha, H. C., Cai, Q., & Robertson, E. S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4313-1_10 · Cited by 3
Neurofibromatosis Type I: From Genetic Mutation to Tumor Formation
Thomas, S. L., & Vries, G. H. D. (2008) · Springer eBooks · doi:10.1007/978-0-387-30375-8_6 · Cited by 3
The p53 Network
Levine, A. J., Bargonetti, J., Bond, G. L., Hoh, J. J., Onel, K., Overholtzer, M., Stoffel, A., Teresky, A. K., Walsh, C. A., & Jin, S. (2005) · Springer eBooks · doi:10.1007/0-387-30127-5_1 · Cited by 3
The Role of the Nucleolus in the Stress Response
Tollini, L. A., Frum, R. A., & Zhang, Y. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0514-6_12 · Cited by 3
p19Arf inhibits aggressive progression of H-ras-driven hepatocellular carcinoma
Kopanja, D., Huang, S., Rasheed, M. R. H. A., Guzman, G., & Raychaudhuri, P. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx140 · Cited by 3
Pinning control applied to gene regulatory networks
Suárez, O. J., Vega, C. J., Sanchez, E. N., Santiago, A. E. G., & García, A. P. (2018) · IEEE Latin American Conference on Computational Intelligence (LA-CCI) · doi:10.1109/la-cci.2018.8625206 · Cited by 3
Glioma Oncogenesis and Animal Models of Glioma Formation
Lyustikman, Y., & Lassman, A. B. (2006) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2006.09.005 · Cited by 3
RING Fingers and Relatives: Determinators of Protein Fate
Lorick, K. L., Tsai, Y. C., Yang, Y., & Weissman, A. M. (2007) · Wiley eBooks · doi:10.1002/9783527619320.ch4 · Cited by 3
Novedades en biología molecular y su aplicación en el diagnóstico y el tratamiento del melanoma
Martorell, A., Requena, C., Estrada, R. B., & Sangüeza, O. P. (2009) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(09)73168-0 · Cited by 3
THE ROLE OF BOVINE ADENOVIRUS-3 PROTEIN V (pV) IN VIRUS REPLICATION
Zhao, X. Y. (2016) · University Library - University of Saskatchewan (University of Saskatchewan) · Cited by 3
The ARF protein in tumor suppression: lessons from mouse models and human tumors
Rodríguez, I. P. (2004) · Clinical & Translational Oncology · doi:10.1007/bf02710031 · Cited by 2
Regulation of p53 Activity and Associated Checkpoint Controls
Post, S. M., Quintás‐Cardama, A., & Lozano, G. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_11 · Cited by 2
Reduced murine double minute 2 and 4 protein, but not messenger RNA , expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia
Salomao, N., Maslah, N., Giulianelli, A., Drevon, L., Aguinaga, L., Gu, X., Cassinat, B., Giraudier, S., Fenaux, P., & Fåhræus, R. (2022) · British Journal of Haematology · doi:10.1111/bjh.18608 · Cited by 2
Novel and Unexpected Role for the Tumor Suppressor ARF in Viral Infection Surveillance
García, M. Á., Muñoz‐Fontela, C., Collado, M., Marcos-Villar, L., Estéban, M., & Rivas, C. (2007) · Future Virology · doi:10.2217/17460794.2.6.625 · Cited by 3
A combined pathway to simulate CDK-dependent phosphorylation and ARF-dependent stabilization for p53 transcriptional activity.
Doi, A., Nagasaki, M., Ueno, K., Matsuno, H., & Miyano, S. (2006) · PubMed · Cited by 2
The Stem Cell Hypothesis of Aging
Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.108 · Cited by 2
Isolation and Characterization of Mammalian Cells Expressing the Arf Promoter During Eye Development
Iqbal, N. S., Xu, L., Devitt, C. C., & Skapek, S. X. (2014) · BioTechniques · doi:10.2144/000114166 · Cited by 2
Meis1 Is Required for c-Met Inhibition to Suppress Cell Proliferation of Skin Squamous Cell Carcinoma Cells
Saito, M., Okumura, K., Yoshizawa, Y., Munakata, H., Isogai, E., & Wakabayashi, Y. (2016) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2016.47007 · Cited by 2
Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency
Leder, A., McMenamin, J., Zhou, F., Moran, J. L., Beier, D. R., & Leder, P. (2007) · Oncogene · doi:10.1038/sj.onc.1210866 · Cited by 2
Lack of Sequence Variation in Sporadic Bovine Leucosis in Regions of Tumour Suppressor Genes p53 and p16
Mayr, B., Grüneis, C., Brem, G., Reifinger, M., Schaffner, G., & Hochsteiner, W. (2001) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1046/j.1439-0442.2001.00371.x · Cited by 2
Inherited Gene Mutations in Melanoma
Pho, L. N., Champine, M., Leachman, S. A., & Kohlmann, W. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3554-3_5 · Cited by 2
Distinct Roles of Direct Transduction Versus Exposure to the Tumor Secretome on Murine Endothelial Cells After Melanoma Gene Therapy with Interferon-β and p19Arf
Vieira, I. D. L., Tamura, R. E., Hunger, A., & Strauss, B. E. (2019) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0124 · Cited by 2
Importance of siRNA negative control selection: Evaluation of non-specific protein knock-down by negative control siRNA (87.42)
Sullivan, Y. B., Hughes, D. E., Narahari, J., & Webb, B. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.supp.87.42 · Cited by 2
Altered Expression Profiles and Defects in a Group of Cell Cycle Regulators and Tumor Suppressor Genes (INK4) and Evaluation of Comprehensive Expression Profiles of Canine miRNAs in Spontaneous Canine Breast Cancer Models
Kabir, L., & Mohammad, F. (2014) · Cited by 2
Human Cancer Genetics
Malkin, D. M., & Barlow, J. W. (2001) · Informa Healthcare eBooks · doi:10.1201/9780203904237.ch1 · Cited by 3
p53, Apoptosis, and Chemosensitivity
Lowe, S. W. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-720-8_2 · Cited by 2
Structure-Function Studies of Human Cytosolic Thymidine Kinase
Berenstein, D. (2009) · RUCforsk (Roskilde University) · Cited by 2
Elevated Type I Interferon Signaling Defines the Proliferative Advantage of ARF and p53 Mutant Tumor Cells
Mabry, A., Kuzmicki, C. E., O’Brien, A., Maggi, L. B., & Weber, J. D. (2025) · Molecular and Cellular Biology · doi:10.1080/10985549.2025.2497817 · Cited by 1
Self-citation
Infection of animal coronaviruses into a bat cell line from the kidney of Pipistrellus abramus
Nakagawa, K., Miyawaki, S., Moribe, J., Masatani, T., Saito, T., & Takashima, Y. (2025) · Journal of Veterinary Medical Science · doi:10.1292/jvms.24-0406 · Cited by 1
A unified therapeutic theory for treating cancer via master regulators of the universal apoptosis network
Joseph, D., Kongoli, F., You, F., & Inufusa, H. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03066-2 · Cited by 2
Drugging p53 mutants: Recent advances using small-molecule modulation strategies
Lopes, E. A., Monteiro, T. G., & Santos, M. M. M. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.119149 · Cited by 1
Understanding Melanocyte Transformation – A Work in Progress
Wangari‐Talbot, J., Goydos, J. S., & Che, S. (2011) · InTech eBooks · doi:10.5772/19753 · Cited by 1
Significance of Retinoblastoma Protein in Survival and Differentiation of Cerebellar Neurons
Padmanabhan, J. (2012) · InTech eBooks · doi:10.5772/32102
MDM2 and MDMX Regulators of p53 Activity
Momand, J. A., Aspuria, P. J., & Furuta, S. (2007) · Springer eBooks · doi:10.1007/0-387-30127-5_7 · Cited by 1
The tumour suppressor function of the scaffolding protein spinophilin
Sarrouilhe, D., & Ladevèze, V. (2014) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/54041 · Cited by 1
The MYC Network and Cancer
Thorgeirsson, S. S., & Factor, V. M. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_24 · Cited by 1
Systemic and Topical Use of Green Tea Polyphenols for Healthy Skin
Holzer, A. M., Yusuf, N., Tisdale, B., Katiyar, S. K., & Elmets, C. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4_7 · Cited by 1
A causal role of ATM- and NEMO-dependent NF-κB activation in DNA damage-induced senescence and aging
Zhao, J. (2016) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
Oxyradicals in Iron Overload Syndromes
Toyokuni, S. (2003) · Oxidative stress and disease · doi:10.1201/9780203912874.ch13 · Cited by 1
Histone Deacetylase Functions in Epidermal Development, Homeostasis and Cancer
Brennan-Crispi, D. M., & Millar, S. E. (2018) · Contributions to management science · doi:10.1007/978-3-319-16769-5_5 · Cited by 1
A wild-derived inbred mouse strain, MSM/Ms, provides insights into novel skin tumor susceptibility genes
Okumura, K., Saito, M., & Wakabayashi, Y. (2021) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.21-0017 · Cited by 1
p16 Tumor Suppressor
Kamb, A., & McCormack, K. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-230-2_8 · Cited by 1
Molecular Biology of Human Brain Tumors
Coluccia, D., Weeks, A., Fandino, J., Schneider, C., Smith, C. A., & Rutka, J. T. (2016) · Springer eBooks · doi:10.1007/978-1-59745-458-2_35 · Cited by 1
Molecular Mechanisms in Formation and Progression of Malignant Melanoma
Turaçlı, İ. D. (2016) · Turkish Journal of Dermatology · doi:10.4274/tdd.3000 · Cited by 1
Targeting Aberrant Signaling Pathways
Mandel, J. J., & Kesari, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-49864-5_9 · Cited by 1
Cell death induction in p53-Mdm2 network regulated by p300 and HDAC1 using pinning control
Suárez, O. J., Vega, C. J., Sanchez, E. N., & Santiago, A. E. G. (2019) · International Conference on Electrical Engineering, Computing Science and Automatic Control (CCE) · doi:10.1109/iceee.2019.8884509 · Cited by 1
Cell Signaling Pathways in Pancreatic Cancer
Fleming, J. B. (2006) · Springer eBooks · doi:10.1007/0-387-21600-6_4 · Cited by 1
UV Response of Mammalian p53 Tumor Supressor Gene
Mälkönen, T. (1999) · Työväentutkimus Vuosikirja · Cited by 1
Transfer of pl4arf gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance
Fan, G., & Zuze, W. (2000) · Chinese Journal of Cancer Research · doi:10.1007/bf02983461 · Cited by 1
Biologie des cancers bronchiques
Madelaine, J., & Zalcman, G. (2004) · Encyclopédie médico-chirurgicale. Pneumologie · doi:10.1016/j.emcpn.2004.10.002 · Cited by 1
The p53 Pathway, Cancer and Aging
Braithwaite, A. W., & Edwards, S. J. (2003) · Springer eBooks · doi:10.1007/978-94-017-0669-8_8 · Cited by 1
Determining the role of p53 mutation in human breast cancer progression using recombinant mutant/wild-type p53 heterozygous human mammary epithelial cell culture models
Junk, D. J. (2008) · UA Campus Repository (The University of Arizona) · Cited by 1
Caspases in c-Myc-induced apoptosis
Hotti, A. (2000) · Työväentutkimus Vuosikirja · Cited by 1
Mdm2 and ARF
Klotzbücher, A., & Kubbutat, M. H. G. (2002) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-59259-153-4_10 · Cited by 1
Genetics, prevention and screening for melanoma
Hershock, D. M. (2005) · Cancer chemotherapy and biological response modifiers · doi:10.1016/s0921-4410(04)22031-2 · Cited by 1
Escaping Cellular Senescence In Vitro
Wadhwa, R., Polly, P., Nagpal, A. K., & Kaul, S. C. (2003) · Springer eBooks · doi:10.1007/978-94-017-0283-6_6 · Cited by 1
The Genetic Etiology of Sporadic Ovarian Cancer
Lancaster, J. M., Havrilesky, L. J., & Berchuck, A. (2003) · Elsevier eBooks · doi:10.1016/b978-012053642-9/50016-8 · Cited by 1
Regulation of the p53 Response by Cellular Growth and Survival Factors
Brown, L. M., & Benchimol, S. (2005) · Springer eBooks · doi:10.1007/978-1-4020-2922-6_5 · Cited by 1
p27, A Prognostic Indicator Reflecting ...?
Koff, A. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-401-6_2
Analise do papel da enzima acido graxo sintase no processo metastatico de melanoma em modelo murino (B16F10/C57BL6)
Carvalho, M. A. (2007) · doi:10.47749/t/unicamp.2007.409068
p53 in Head and Neck Cancer
Roh, J.-L., & Koch, W. M. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8815-6_12
TP53 in Carcinogenesis and Cancer Prevention
Gormally, E., & Hainaut, P. L. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-08602-5_5
Tumor suppressor p53 and transcriptional changes in cellular stress responses to UV radiation
Latonen, L. (2003) · Työväentutkimus Vuosikirja
Transferência gênica de p19Arf e interferon-b em células de melanoma.
Ribeiro, A. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.87.2011.tde-10022012-143841
The Biology ofMYCin Health and Disease: A High Altitude View
Turner, B. C., Bird, G. A., & Refaeli, Y. (2010) · Wiley eBooks · doi:10.1002/9783527630332.ch1
Defining the Role of CtBP2 in p53-Independent Tumor Suppressor Function of ARF: A Dissertation
Kovi, R. C. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/86d1-1y04
E2F1 induction following DNA damage and oncogene activation
Helgason, G. V. (2007) · Enlighten: Theses (The University of Glasgow)
A Tale of Two ARFs: Tumor Suppressor and Anti-viral Functions of p14ARF: A Dissertation
Straza, M. W. (2010) · eScholarship@UMassChan · doi:10.13028/e1vv-ka50
An Overview of Important Genetic Aspects in Melanoma
Rohinton, S. (2013) · InTech eBooks · doi:10.5772/55257
FUNCTION OF ZNF668 IN CANCER DEVELOPMENT
Hu, R. (2011) · Digital Commons-TMC (Texas Medical Center)
The induction and suppression of apoptosis by viruses
Hammond, E. M., & Grande, R. J. A. (2001) · Perspectives in medical virology · doi:10.1016/s0168-7069(01)05013-3
Mechanisms of Spontaneous Melanoma Regression in MeLiM PigsPreprint
Rambow, F. (2008)
Systems Biology of Glioblastoma Multiforme
Agha, C. A., Machemehl, H. C., & Fathallah‐Shaykh, H. M. (2015) · InTech eBooks · doi:10.5772/59642
The role of NOTCH2 gene in human malignant glial brain tumours
Sivasankaran, B. (2008) · edoc (University of Basel) · doi:10.5451/unibas-004761437
To reactivate or not to reactivate : Control of KSHV lytic replication is essential for apoptosis in response to p53 restoration
Sarek, G. (2010) · Työväentutkimus Vuosikirja
The Role of Human Cytomegalovirus Immediate Early Proteins in Cell Growth Control: A Dissertation
Castillo, J. (2002) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/ah89-m980
Myc-Funktion im Zellwachstum und Identifikation von neuen Myc-regulierten Genen in B-Zellen
Schuhmacher, M. (2001) · doi:10.5282/edoc.136
Mechanisms of p53-mediated intrinsic and extrinsic tumor suppression
Li, H. (2014) · Figshare
The Biology and Genetics of Melanoma
Sharpless, N. E., & Chin, L. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-994-3_15
Post-translational Modifications of the p53 Transcription Factor
Brooks, C. L., & Gu, W. J. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_15
The Epidemiology, Biology and Genetics of Human Astrocytic Tumours
Bäcklund, L. M. (2005) · Figshare

Authors: Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., & Sherr, C. J.
Affiliations: St. Jude Children's Research Hospital (US)
Howard Hughes Medical Institute and Departments of Tumor Cell Biology and Biochemistry, St. Jude Children’s Research Hospital, 332 North Lauderdale, Memphis, TN 38105
Corresponding author: Sherr, Charles J.
ORCID: Kamijo, Takehiko
Weber, Jason D.
Zambetti, Gerard
Roussel, Martine F.
Sherr, Charles J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-07-07
Volume: 95
Issue: 14
Pages: 8292-8297
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.14.8292
PMC: PMC20969
OpenAlex: W2141529421
Cited by: 899
References: 61
Citations by year: 2026: 5 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 15 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 26 · 2015: 21 · 2014: 33 · 2013: 28 · 2012: 34
FWCI: 31.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: St. Jude Children's Research Hospital (CA21765)
American Lebanese Syrian Associated Charities (CA 21765)
National Institutes of Health (CA21765))
National Cancer Institute (R01CA063230, CA-71907, CA-63230, CA21765, P30CA021765, P01CA071907)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: p19ARF, p53, MDM2, INK4a/ARF locus, p16INK4a, protein-protein interaction, p53 stabilization, p21 Cip1, cell cycle arrest, p53-dependent transcription, tumor suppressor, p53 DNA binding, N-terminal domain
MeSH terms: Animals, Humans, Neoplasm Proteins, Nuclear Proteins, Proteins, Proto-Oncogene Proteins, Retroviridae, Transfection, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, 3T3 Cells, Tumor Suppressor Protein p14ARF, Mice, Proto-Oncogene Proteins c-mdm2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks