Sherr, Charles J.

CDK inhibitors: positive and negative regulators of G1-phase progression

Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 6,115

Cancer Cell Cycles

Sherr, C. J. (1996) · Science

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 5,379

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

Diehl, J. A., Cheng, M., Roussel, M. F., & Sherr, C. J. (1998) · Genes & Development

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 2,130

The RB and p53 pathways in cancer

Sherr, C. J., & McCormick, F. (2002) · Cancer Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 1,690

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Kamijo, T., Zindy, F., Roussel, M. F., Quelle, D. E., Downing, J. R., Ashmun, R. A., Grosveld, G., & Sherr, C. J. (1997) · Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,566

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Ouelle, D. E., Zindy, F., Ashmun, R. A., & Sherr, C. J. (1995) · Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 1,485

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

Kato, J., Matsushime, H., Hiebert, S. W., Ewen, M. E., & Sherr, C. J. (1993) · Genes & Development

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,264

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Zindy, F., Eischen, C. M., Randle, D. H., Kamijo, T., Cleveland, J. L., Sherr, C. J., & Roussel, M. F. (1998) · Genes & Development

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,245

The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

Cheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., & Sherr, C. J. (1999) · The EMBO Journal

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,142

Forging a signature of in vivo senescence

Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,104

Living with or without cyclins and cyclin-dependent kinases

Sherr, C. J., & Roberts, J. M. (2004) · Genes & Development

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 1,089

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J.-Y., & Livingston, D. M. (1993) · Cell

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 1,010

D-type cyclins

Sherr, C. J. (1995) · Trends in Biochemical Sciences

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 980

Nucleolar Arf sequesters Mdm2 and activates p53

Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., & Bar-Sagi, D. (1999) · Nature Cell Biology

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 940

Targeting CDK4 and CDK6: From Discovery to Therapy

Sherr, C. J., Beach, D., & Shapiro, G. I. (2016) · Cancer Discovery

Advanced Breast Cancer TherapiesCancer-related Molecular Pathways

Cited by 936

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., & Sherr, C. J. (1998) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 899

Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D type G1 cyclins

Matsushime, H., Ewen, M. E., Strom, D. K., Kato, J.-Y., Hanks, S. K., Roussel, M. F., & Sherr, C. J. (1992) · Cell

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 897

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Eischen, C. M., Weber, J. D., Roussel, M. F., Sherr, C. J., & Cleveland, J. L. (1999) · Genes & Development

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 819

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Diehl, J. A., Zindy, F., & Sherr, C. J. (1997) · Genes & Development

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 746

Cellular Senescence

Sherr, C. J., & DePinho, R. A. (2000) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 745

Tumor suppression by Ink4a-Arf: progress and puzzles.

Lowe, S. W., & Sherr, C. J. (2003) · Current Opinion in Genetics & Development

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 699

The ARF/p53 pathway.

Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 654

Divorcing ARF and p53: an unsettled case

Sherr, C. J. (2006) · Nature reviews. Cancer

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 595

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging

Zindy, F., Quelle, D. E., Roussel, M. F., & Sherr, C. J. (1997) · Oncogene

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 574