The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases
Open accessAbstract
Bloom’s syndrome (BS) and Werner’s syndrome (WS) are genetic disorders in which an increased rate of chromosomal aberration is detected. The genes responsible for these diseases, BLM and WRN , have been found to be homologs of Escherichia coli recQ and Saccharomyces cerevisiae SGS1 genes. Here we show that yeast Sgs1 helicase acts as a suppressor of illegitimate recombination through homologous recombination and that human BLM and WRN helicases can suppress the increased homologous and illegitimate recombinations in the S. cerevisiae sgs1 mutant. The results imply a role of BLM and WRN helicases to control genomic stability in human cells. Similar to Sgs1 helicase, BLM helicase suppressed the cell growth in the top3 sgs1 mutation background and restored the increased sensitivity of the sgs1 mutant to hydroxyurea, but the WRN helicase did not. We discussed differential roles of BLM and WRN helicases in human cells. BLM- and WRN-bearing yeasts provide new useful models to investigate human BS and WS diseases.
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Citations
Cites
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Cited by
Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome
Kitao, S., Shimamoto, A., Goto, M., Miller, R. W., Smithson, W. A., Lindor, N. M., & Furuichi, Y. (1999) · Nature Genetics · doi:10.1038/8788 · Cited by 666
Self-citationPaeschke, K., Capra, J. A., & Zakian, V. A. (2011) · Cell · doi:10.1016/j.cell.2011.04.015 · Cited by 566
Mullen, J. R., Kaliraman, V., Ibrahim, S. S., & Brill, S. J. (2001) · Genetics · doi:10.1093/genetics/157.1.103 · Cited by 403
The Bloom's Syndrome Gene Product Interacts with Topoisomerase III
Wu, L., Davies, S. L., North, P. S., Goulaouic, H., Riou, J.-F., Turley, H., Gatter, K. C., & Hickson, I. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9636 · Cited by 318
Functional and Physical Interaction between WRN Helicase and Human Replication Protein A
Brosh, R. M., Orren, D. K., Nehlin, J. O., Ravn, P. H., Kenny, M. K., Machwe, A., & Bohr, V. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18341 · Cited by 306
Metadata
- Authors
- Yamagata, K., Kato, J.-I., Shimamoto, A., Goto, M., Furuichi, Y., & Ikeda, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8733-8738
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989971670
- Cited by
- 294
- References
- 1
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases. https://app.cochat.ai/papers/10.1073/pnas.95.15.8733
- The paper
- Yamagata, K., Kato, J.-I., Shimamoto, A., Goto, M., Furuichi, Y., & Ikeda, H. (1998). Bloom’s and Werner’s syndrome genes suppress hyperrecombination in yeast sgs1 mutant: Implication for genomic instability in human diseases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.15.8733
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