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Cited by 567

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Myocyte proliferation in end-stage cardiac failure in humans

Open access
Kajstura, Jan, Leri, Annarosa, Finato, Nicoletta, Di Loreto, Carla, Beltrami, Carlo A., Anversa, Piero·1998·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.95.15.8801
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Abstract

Introduced several decades ago, the dogma persists that cardiac myocytes are terminally differentiated cells and that division of muscle cells is impossible in the adult heart. More recently, nuclear mitotic divisions in myocytes occasionally were seen, but those observations were challenged on the assumption that the rate of cell proliferation was inconsequential for actual tissue regeneration. Moreover, mitoses were never detected in normal myocardium. However, the analysis of routine histologic preparations constituted the basis for the belief that myocytes were unable to reenter the cell cycle and divide, ignoring the limitations of these techniques. We report here by confocal microscopy that 14 myocytes per million were in mitosis in control human hearts. A nearly 10-fold increase in this parameter was measured in end-stage ischemic heart disease (152 myocytes per million) and in idiopathic dilated cardiomyopathy (131 myocytes per million). Because the left ventricle contains 5.8 × 10 9 myocytes, these mitotic indices imply that 81.2 × 10 3 , 882 × 10 3 , and 760 × 10 3 myocytes were in mitosis in the entire ventricular myocardium of control hearts and hearts affected by ischemic and idiopathic dilated cardiomyopathy, respectively. Additionally, mitosis lasts less than 1 hr, suggesting that large numbers of myocytes can be formed in the nonpathologic and pathologic heart with time. Evidence of cytokinesis in myocytes was obtained, providing unequivocal proof of myocyte proliferation.

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Metadata

Authors
Kajstura, J., Leri, A., Finato, N., Di Loreto, C., Beltrami, C. A., & Anversa, P.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1998-07-21
Volume
95
Issue
15
Pages
8801-8805
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.95.15.8801
OpenAlex
W1981522023
Cited by
567
References
20
FWCI
5.74
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Myocyte proliferation in end-stage cardiac failure in humans. https://app.cochat.ai/papers/10.1073/pnas.95.15.8801
The paper
Kajstura, J., Leri, A., Finato, N., Di Loreto, C., Beltrami, C. A., & Anversa, P. (1998). Myocyte proliferation in end-stage cardiac failure in humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.15.8801

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.