Cited by 273Mast cells and histamineTissue Engineering and Regenerative MedicineOrthopaedic implants and arthroplasty

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Mast cells mediate acute inflammatory responses to implanted biomaterials

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Tang, Liping, Jennings, Timothy A., Eaton, John W.·1998·Proceedings of the National Academy of Sciences

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Abstract

Implanted biomaterials trigger acute and chronic inflammatory responses. The mechanisms involved in such acute inflammatory responses can be arbitrarily divided into phagocyte transmigration, chemotaxis, and adhesion to implant surfaces. We earlier observed that two chemokines-macrophage inflammatory protein 1alpha/monocyte chemoattractant protein 1-and the phagocyte integrin Mac-1 (CD11b/CD18)/surface fibrinogen interaction are, respectively, required for phagocyte chemotaxis and adherence to biomaterial surfaces. However, it is still not clear how the initial transmigration of phagocytes through the endothelial barrier into the area of the implant is triggered. Because implanted biomaterials elicit histaminic responses in the surrounding tissue, and histamine release is known to promote rapid diapedesis of inflammatory cells, we evaluated the possible role of histamine and mast cells in the recruitment of phagocytes to biomaterial implants. Using i.p. and s. c. implantation of polyethylene terephthalate disks in mice we find: (i) Extensive degranulation of mast cells, accompanied by histamine release, occurs adjacent to short-term i.p. implants. (ii) Simultaneous administration of H1 and H2 histamine receptor antagonists (pyrilamine and famotidine, respectively) greatly diminishes recruitment and adhesion of both neutrophils (<20% of control) and monocytes/macrophages (<30% of control) to implants. (iii) Congenitally mast cell-deficient mice also exhibit markedly reduced accumulation of phagocytes on both i.p. and s.c implants. (iv) Finally, mast cell reconstitution of mast cell-deficient mice restores "normal" inflammatory responses to biomaterial implants. We conclude that mast cells and their granular products, especially histamine, are important in recruitment of inflammatory cells to biomaterial implants. Improved knowledge of such responses may permit purposeful modulation of both acute and chronic inflammation affecting implanted biomaterials.

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Authors: Tang, L., Jennings, T. A., & Eaton, J. W.
Affiliations: Baylor College of Medicine (US)
ORCID: Tang, Liping
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-07-21
Volume: 95
Issue: 15
Pages: 8841-8846
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.15.8841
PMC: PMC21164
OpenAlex: W2037046845
Cited by: 272
References: 78
Citations by year: 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 18 · 2020: 19 · 2019: 8 · 2018: 11 · 2017: 19 · 2016: 16 · 2015: 12 · 2014: 8 · 2013: 14 · 2012: 8
FWCI: 1.56
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
Keywords: mast cells, histamine, biomaterial implantation, acute inflammation, phagocyte recruitment, neutrophil transmigration, monocyte adhesion, histamine H1 receptor antagonists, H2 receptor antagonists, mast cell-deficient mice, transendothelial migration, macrophage inflammatory protein-1alpha, Mac-1
MeSH terms: Animals, Biocompatible Materials, Histamine, Histamine Release, Inflammation, Mast Cells, Phagocytes, Cell Degranulation, Mice

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Mast cells mediate acute inflammatory responses to implanted biomaterials

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