The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Mast cells mediate acute inflammatory responses to implanted biomaterials
Open accessAbstract
Implanted biomaterials trigger acute and chronic inflammatory responses. The mechanisms involved in such acute inflammatory responses can be arbitrarily divided into phagocyte transmigration, chemotaxis, and adhesion to implant surfaces. We earlier observed that two chemokines-macrophage inflammatory protein 1alpha/monocyte chemoattractant protein 1-and the phagocyte integrin Mac-1 (CD11b/CD18)/surface fibrinogen interaction are, respectively, required for phagocyte chemotaxis and adherence to biomaterial surfaces. However, it is still not clear how the initial transmigration of phagocytes through the endothelial barrier into the area of the implant is triggered. Because implanted biomaterials elicit histaminic responses in the surrounding tissue, and histamine release is known to promote rapid diapedesis of inflammatory cells, we evaluated the possible role of histamine and mast cells in the recruitment of phagocytes to biomaterial implants. Using i.p. and s. c. implantation of polyethylene terephthalate disks in mice we find: (i) Extensive degranulation of mast cells, accompanied by histamine release, occurs adjacent to short-term i.p. implants. (ii) Simultaneous administration of H1 and H2 histamine receptor antagonists (pyrilamine and famotidine, respectively) greatly diminishes recruitment and adhesion of both neutrophils (<20% of control) and monocytes/macrophages (<30% of control) to implants. (iii) Congenitally mast cell-deficient mice also exhibit markedly reduced accumulation of phagocytes on both i.p. and s.c implants. (iv) Finally, mast cell reconstitution of mast cell-deficient mice restores "normal" inflammatory responses to biomaterial implants. We conclude that mast cells and their granular products, especially histamine, are important in recruitment of inflammatory cells to biomaterial implants. Improved knowledge of such responses may permit purposeful modulation of both acute and chronic inflammation affecting implanted biomaterials.
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In the citing paper
“The recruitment is mediated by mast cells, which secrete granular products that attract and promote the adhesion of monocytes and macrophages to the implant.[ 34 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [34]
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In the citing paper
“Mast cell degranulation with histamine release and fibrinogen adsorption is known to mediate acute inflammatory responses to implanted biomaterials.[6, 7]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [7]
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“In addition, mast cell degranulation and release of histamine has been shown to play an integral role in recruiting phagocytes, including macrophages, to the site of the implanted biomaterial.[7]”
From Foreign body reaction to biomaterials (2008) · cites this paper as [7]
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Citations
Cites
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Self-citation
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Cited by
Sorted by citations
Foreign body reaction to biomaterials
Anderson, J. M., Rodriguez, A., & Chang, D. T. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.11.004 · Cited by 5,138
“a A da pt ed fr om re fe re nc es : [ 12 2, 12 4– 12 6, 15 2– 15 7]”
BackgroundFranz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391
Osteoimmunomodulation for the development of advanced bone biomaterials
Chen, Z., Klein, T. J., Murray, R. Z., Crawford, R., Chang, J., Wu, C., & Xiao, Y. (2015) · Materials Today · doi:10.1016/j.mattod.2015.11.004 · Cited by 752
Biomaterials: Foreign Bodies or Tuners for the Immune Response?
Mariani, E., Lisignoli, G., Borzì, R. M., & Pulsatelli, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030636 · Cited by 706
“Mast cells are consistently reported at the site of implantation [81–83], where they degranulate upon activation, releasing histamine (shown to play a role in directing neutrophils and monocytes to implanted biomaterials [82,84] and secreting pro- and anti-inflammatory cytokines, angiogenic, and pro-fibrotic factors (…”
BackgroundBryers, J. D. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.21838 · Cited by 732
“MIP-1α and MCP-1 have been implicated in phagocyte chemotaxis towards implants (Tang et al., 1998).”
Background
Metadata
- Authors
- Tang, L., Jennings, T. A., & Eaton, J. W.
- Affiliations
- Baylor College of Medicine (US)
- ORCID
- Tang, Liping
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8841-8846
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21164
- OpenAlex
- W2037046845
- Cited by
- 272
- References
- 78
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 6 · 2022: 4 · 2021: 18 · 2020: 19 · 2019: 8 · 2018: 11 · 2017: 19 · 2016: 16 · 2015: 12 · 2014: 8 · 2013: 14 · 2012: 8
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Orthopaedic implants and arthroplasty
- Keywords
- mast cells, histamine, biomaterial implantation, acute inflammation, phagocyte recruitment, neutrophil transmigration, monocyte adhesion, histamine H1 receptor antagonists, H2 receptor antagonists, mast cell-deficient mice, transendothelial migration, macrophage inflammatory protein-1alpha, Mac-1
- MeSH terms
- Animals, Biocompatible Materials, Histamine, Histamine Release, Inflammation, Mast Cells, Phagocytes, Cell Degranulation, Mice
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