Functional connectivity of the angular gyrus in normal reading and dyslexia
Open accessAbstract
The classic neurologic model for reading, based on studies of patients with acquired alexia, hypothesizes functional linkages between the angular gyrus in the left hemisphere and visual association areas in the occipital and temporal lobes. The angular gyrus also is thought to have functional links with posterior language areas (e.g., Wernicke's area), because it is presumed to be involved in mapping visually presented inputs onto linguistic representations. Using positron emission tomography , we demonstrate in normal men that regional cerebral blood flow in the left angular gyrus shows strong within-task, across-subjects correlations (i.e., functional connectivity) with regional cerebral blood flow in extrastriate occipital and temporal lobe regions during single word reading. In contrast, the left angular gyrus is functionally disconnected from these regions in men with persistent developmental dyslexia, suggesting that the anatomical disconnection of the left angular gyrus from other brain regions that are part of the "normal" brain reading network in many cases of acquired alexia is mirrored by its functional disconnection in developmental dyslexia.
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Functional areas probably include the left angular gyrus, left inferior frontal cortex, and temporal regions anterior to the VWFA.
“Although the precise projections from VWFA to systems involved in lexical, semantic and phonological processes are currently less clearly defined, functional areas probably include the left angular gyrus [52], left inferior frontal cortex [53], and temporal regions anterior to the VWFA [54].”
From The visual word form area: expertise for reading in the fusiform gyrus (2003) · cites this paper as [52]
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References 37 · Cited by 607
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- Authors
- Horwitz, B., Rumsey, J. M., & Donohue, B. C.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Horwitz, B.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8939-8944
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC21181
- OpenAlex
- W1997846670
- Cited by
- 607
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 13 · 2022: 19 · 2021: 12 · 2020: 16 · 2019: 19 · 2018: 16 · 2017: 16 · 2016: 20 · 2015: 21 · 2014: 25 · 2013: 32 · 2012: 35
- FWCI
- 36.05
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- angular gyrus, functional connectivity, developmental dyslexia, reading network, regional cerebral blood flow, visual word recognition, occipital lobe, temporal lobe, Wernicke's area, neuroimaging of reading
- MeSH terms
- Adolescent, Adult, Dyslexia, Humans, Male, Reading, Regional Blood Flow, Tomography, Emission-Computed, Dentate Gyrus
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