The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
Open accessAbstract
Although physiological and pharmacological evidence suggests the presence of multiple tetrodotoxin-resistant (TTX-R) Na channels in neurons of peripheral nervous system ganglia, only one, SNS/PN3, has been identified in these cells to date. We have identified and sequenced a novel Na channel α-subunit (NaN), predicted to be TTX-R and voltage-gated, that is expressed preferentially in sensory neurons within dorsal root ganglia (DRG) and trigeminal ganglia. The predicted amino acid sequence of NaN can be aligned with the predicted structure of known Na channel α-subunits; all relevant landmark sequences, including positively charged S4 and pore-lining SS1–SS2 segments, and the inactivation tripeptide IFM, are present at predicted positions. However, NaN exhibits only 42–53% similarity to other mammalian Na channels, including SNS/PN3, indicating that it is a novel channel, and suggesting that it may represent a third subfamily of Na channels. NaN transcript levels are reduced significantly 7 days post axotomy in DRG neurons, consistent with previous findings of a reduction in TTX-R Na currents. The preferential expression of NaN in DRG and trigeminal ganglia and the reduction of NaN mRNA levels in DRG after axonal injury suggest that NaN, together with SNS/PN3, may produce TTX-R currents in peripheral sensory neurons and may influence the generation of electrical activity in these cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structural features in eukaryotic mRNAs that modulate the initiation of translation.
Kozak, M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54860-2 · Cited by 1,836
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
Akopian, A. N., Sivilotti, L., & Wood, J. N. (1996) · Nature · doi:10.1038/379257a0 · Cited by 1,103
STRUCTURE AND FUNCTION OF VOLTAGE-GATED ION CHANNELS
Catterall, W. A. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002425 · Cited by 948
Existence of distinct sodium channel messenger RNAs in rat brain
Noda, M., Ikeda, T., Kayano, T., Suzuki, H., Takeshima, H., Kurasaki, M., Takahashi, H., & Numa, S. (1986) · Nature · doi:10.1038/320188a0 · Cited by 906
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
West, J. W., Patton, D. E., Scheuer, T., Wang, Y., Goldin, A. L., & Catterall, W. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10910 · Cited by 830
Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones.
Harper, A. A., & Lawson, S. N. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015573 · Cited by 745
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.
Gold, M. S., Reichling, D. B., Shuster, M. J., & Levine, J. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1108 · Cited by 668
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels
Yang, N., George, A. L., & Horn, R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80028-8 · Cited by 605
Waxman, S. G., Kocsis, J. D., & Black, J. A. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.1.466 · Cited by 552
Self-citationEngland, S., Bevan, S., & Docherty, R. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021604 · Cited by 549
Cited by
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
Self-citationResurgence of sodium channel research
Goldin, A. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.871 · Cited by 688
Transcriptional and posttranslational plasticity and the generation of inflammatory pain
Woolf, C. J., & Costigan, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7723 · Cited by 555
Blair, N. T., & Bean, B. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10277.2002 · Cited by 426
Metadata
- Authors
- Dib-Hajj, S. D., Tyrrell, L., Black, J. A., & Waxman, S. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-07-21
- Volume
- 95
- Issue
- 15
- Pages
- 8963-8968
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1985689777
- Cited by
- 503
- References
- 51
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. https://app.cochat.ai/papers/10.1073/pnas.95.15.8963
- The paper
- Dib-Hajj, S. D., Tyrrell, L., Black, J. A., & Waxman, S. G. (1998). NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.15.8963
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
