The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis
Open accessAbstract
The Arabidopsis genes EDS1 and NDR1 were shown previously by mutational analysis to encode essential components of race-specific disease resistance. Here, we examined the relative requirements for EDS1 and NDR1 by a broad spectrum of Resistance ( R ) genes present in three Arabidopsis accessions (Columbia, Landsberg- erecta , and Wassilewskija). We show that there is a strong requirement for EDS1 by a subset of R loci ( RPP2 , RPP4 , RPP5 , RPP21 , and RPS4 ), conferring resistance to the biotrophic oomycete Peronospora parasitica , and to Pseudomonas bacteria expressing the avirulence gene avrRps4 . The requirement for NDR1 by these EDS1 -dependent R loci is either weak or not measurable. Conversely, three NDR1 -dependent R loci, RPS2 , RPM1 , and RPS5 , operate independently of EDS1 . Another RPP locus, RPP8 , exhibits no strong exclusive requirement for EDS1 or NDR1 in isolate-specific resistance to P. parasitica , although resistance is compromised weakly by eds1 . Similarly, resistance conditioned by two EDS1 -dependent RPP genes, RPP4 and RPP5 , is impaired partially by ndr1 , implicating a degree of pathway cross-talk. Our results provide compelling evidence for the preferential utilization of either signaling component by particular R genes and thus define at least two disease resistance pathways. The data also suggest that strong dependence on EDS1 or NDR1 is governed by R protein structural type rather than pathogen class.
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Self-citationStructure of the Arabidopsis RPM1 Gene Enabling Dual Specificity Disease Resistance
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Metadata
- Authors
- Aarts, N., Metz, M., Holub, E., Staskawicz, B. J., Daniels, M. J., & Parker, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1998-08-18
- Volume
- 95
- Issue
- 17
- Pages
- 10306-10311
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2016032876
- Cited by
- 788
- References
- 24
- FWCI
- 35.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. https://app.cochat.ai/papers/10.1073/pnas.95.17.10306
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- Aarts, N., Metz, M., Holub, E., Staskawicz, B. J., Daniels, M. J., & Parker, J. E. (1998). Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.95.17.10306
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